Rchr
J-GLOBAL ID：201901001213394330
Update date: Sep. 02, 2024
Sato Hideaki
サトウ ヒデアキ | Sato Hideaki
Affiliation and department：
Job title：
Associate Professor
Research field (1)：
Functional biochemistry
Research keywords (5)：
生体機能関連化学
, 酵素化学
, heme protein
, porphyrin
, heme biosynthesis
Research theme for competitive and other funds (20)：
- 2022 - 2025 Mechanism of construction and cyclization of the heme precursor tetrapyrrole
- 2019 - 2022 Structural study of cytochrome P450-reductase complex to elucidate electron transfer mechanism
- 2018 - 2021 Elucidation of the construction mechanism of porphyrin ring essential for organisms: Formation and cyclization of tetrapyrrole
- 2016 - 2019 Elucidation of the electron transfer mechanism from cytochrome P450 oxidoreductase to cytochrome P450
- 2015 - 2018 Evaluation study of antioxidative abilities of the keto-carotenoid species found in photosynthetic bacteria
- 2015 - 2018 Investigation of biosynthetic mechanism of cyclic tetrapyrrole: Construction and cyclization of hydroxymethylbilane
- 2014 - 2017 Studies on structural biology of the enzymes involved in porphyria
- 2012 - 2015 The mechanism of construction and cyclization of tetrapyrrole in the heme biosynthetic pathway
- 2012 - 2015 Electron transfer sytem to heme oxygenase from cytochrome P450
- 2009 - 2011 Investigation of the intermediary steps and electron transfer mechanism of heme degradation by heme oxygenase
- 2007 - 2009 Investigation of the mechanism of heme degradation by heme oxygenase-1
- 2006 - 2008 PHYSIOLOGICAL ROLE OF THE SIDE-CHAIN ASYMMETRY OF PORPHYRINES THAT ARE UTILIZED IN NATURE
- 2006 - 2008 The intermediate steps of heme oxygenase reaction and the physiological significance of carbon monoxide as a gaseous transmitter
- 2005 - 2006 シトクロムb_<562>を構造基盤とする新規金属酵素の構築
- 1997 - 2000 TOXIN-DIRECTED MOLECULAR CONVERSION SYSTEM WITH YEAST HARBORING HIGHLY ACTIVATED P450 ENZYME BY ARTIFICIAL MUTAGENESIS
- 1998 - 1998 部位特異的変異法によるNO合成酵素の電子移動機構と酸素分子活性化機構の解明
- 1997 - 1997 部位特異的変異法によるNO合成酵素の電子移動機構と酸素分子活性化機構の解明
- 1996 - 1996 部位特異的変異法によるNO合成酵素の電子移動機構と酸素分子活性化機構の解明
- 1995 - 1996 Development and Characterization of Biotransformation System toward Helogenated Compounds with Yeast
- 1995 - 1996 Structure-Function Relationship of Biodeseigned NO Synthase and Dynamics of NO
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Papers (40)：
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Hideaki Sato, Masakazu Sugishima, Mai Tsukaguchi, Takahiro Masuko, Mikuru Iijima, Mitsunori Takano, Yoshiaki Omata, Kei Hirabayashi, Kei Wada, Yoshio Hisaeda, et al. Crystal structures of hydroxymethylbilane synthase complexed with a substrate analog: A single substrate-binding site for four consecutive condensation steps. Biochemical Journal. 2021. 478. 5. 1023-1042
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Masakazu Sugishima, Junichi Taira, Tatsuya Sagara, Ryota Nakao, Hideaki Sato, Masato Noguchi, Keiichi Fukuyama, Ken Yamamoto, Takuo Yasunaga, Hiroshi Sakamoto. Conformational equilibrium of NADPH-cytochrome P450 oxidoreductase is essential for heme oxygenase reaction. Antioxidants. 2020. 9. 8. 1-13
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Masakazu Sugishima, Hideaki Sato, Kei Wada, Ken Yamamoto. Crystal structure of a NADPH-cytochrome P450 oxidoreductase (CYPOR) and heme oxygenase 1 fusion protein implies a conformational change in CYPOR upon NADPH/NADP+ binding. FEBS Letters. 2019. 593. 8. 868-875
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Haruna Takao, Kei Hirabayashi, Yuki Nishigaya, Haruna Kouriki, Tetsuko Nakaniwa, Yoshinori Hagiwara, Jiro Harada, Hideaki Sato, Toshimasa Yamazaki, Yoichi Sakakibara, et al. A substrate-bound structure of cyanobacterial biliverdin reductase identifies stacked substrates as critical for activity. Nature Communications. 2017. 8. 14397-14397
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Yoshinori Hagiwara, Kei Wada, Teppei Irikawa, Hideaki Sato, Masaki Unno, Ken Yamamoto, Keiichi Fukuyama, Masakazu Sugishima. Atomic-resolution structure of the phycocyanobilin:ferredoxin oxidoreductase I86D mutant in complex with fully protonated biliverdin. FEBS Letters. 2016. 590. 19. 3425-3434
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MISC (113)：
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Masakazu Sugishima, Junichi Taira, Mikuru Iijima, Hideaki Sato, Kei Wada, Masato Noguchi, Keiichi Fukuyama, Mitsunori Takano, Hiroshi Sakamoto, Ken Yamamoto. Domain movements of NADPH-cytochrome P450 oxidoreductase (CPR) are required for the smooth electron transfer from CPR to heme-heme oxygenase-1 (HO-1) complex. 25th Congress of the International Union of Crystallography. 2021
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佐藤秀明, 杉島正一, 塚口 舞, 増子隆博, 小俣義明, 和田 啓, 久枝良雄, 山本 健. 基質誘導体を結合したヒドロキシメチルビランシンターゼ反応中間体の構造解析. 第43回蛋白質と酵素の構造と機能に関する九州シンポジウム. 2019
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ヘム生合成経路におけるピロール結合反応の分子機構. 第92回日本生化学会大会 シンポジウム「テトラピロール色素が織りなす多様な機能とその生合成系の最前線」. 2019
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佐藤秀明, 杉島正一, 塚口 舞, 増子隆博, 小俣義明, 和田 啓, 久枝良雄, 山本 健. ヒドロキシメチルビラン合成酵素の反応中間体と基質誘導体との複合体の結晶構造解析. 2019年度日本生化学会九州支部例会. 2019
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佐藤秀明, 杉島正一, 塚口 舞, 増子隆博, 小俣義明, 和田 啓, 久枝良雄, 山本 健. 基質誘導体を結合したヒト由来ヒドロキシメチルビランシンターゼ反応中間体の結晶構造解析. 第19回日本蛋白質科学会年会 第71回日本細胞生物学会大会 合同年次大会. 2019
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Education (2)：
- 1993 - 1995 Tohoku University Graduate School of Science Department of Chemistry
- 1989 - 1993 Tohoku University Faculty of Science Department of Chemistry
Professional career (1)：
- Doctor of Philosophy (Science) (Tohoku University)
Work history (13)：
- 2016/04 - 現在 KOGA International Nursing School
- 2008/10 - 現在 Kurume University School of Medicine Associate Professor
- 2006/04 - 現在 Kurume University
- 2008/02 - 2008/09 Kurume University School of Medicine Assistant Professor
- 2006/04 - 2008/03 久留米医師会看護専門学校 非常勤講師
- 2007/04 - 2008/01 Kurume University School of Medicine Assistant Professor
- 2005/10 - 2007/03 Kurume University School of Medicine Research Associate
- 2005/04 - 2005/09 RIKEN Harima Institute
- 2004/04 - 2005/03 Kyushu University Faculty of Engineering
- 2003/10 - 2004/03 Kyushu University Faculty of Engineering
- 2001/04 - 2003/09 科学技術振興事業団 さきがけ研究21 グループメンバー(博士研究員)
- 1999/04 - 2001/03 Vanderbilt University School of Medicine Research Fellow
- 1995/04 - 1999/03 Tohoku University Institute for Chemical Reaction Science Research Assistant
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Awards (1)：
- 2000/06 - (The American Society for Biochemistry and Molecular Biology & the American Society for Pharmacology and Experimental Therapeutics Joint Meeting 2000) ASBMB Graduate/Postdoctoral Travel Award
Association Membership(s) (4)：
日本蛋白質科学会
, 日本化学会生体機能関連化学部会
, 日本生化学会
, 日本化学会
