Sato Hideaki

サトウヒデアキ | Sato Hideaki

Affiliation and department：

Research field (1)： Functional biochemistry

Research theme for competitive and other funds (20)：

2022 - 2025 Mechanism of construction and cyclization of the heme precursor tetrapyrrole
2019 - 2022 Structural study of cytochrome P450-reductase complex to elucidate electron transfer mechanism
2018 - 2021 Elucidation of the construction mechanism of porphyrin ring essential for organisms: Formation and cyclization of tetrapyrrole
2016 - 2019 Elucidation of the electron transfer mechanism from cytochrome P450 oxidoreductase to cytochrome P450
2015 - 2018 Evaluation study of antioxidative abilities of the keto-carotenoid species found in photosynthetic bacteria

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Papers (38)：

Hideaki Sato, Masakazu Sugishima, Mai Tsukaguchi, Takahiro Masuko, Mikuru Iijima, Mitsunori Takano, Yoshiaki Omata, Kei Hirabayashi, Kei Wada, Yoshio Hisaeda, et al. Crystal structures of hydroxymethylbilane synthase complexed with a substrate analog: A single substrate-binding site for four consecutive condensation steps. Biochemical Journal. 2021. 478. 5. 1023-1042
Masakazu Sugishima, Junichi Taira, Tatsuya Sagara, Ryota Nakao, Hideaki Sato, Masato Noguchi, Keiichi Fukuyama, Ken Yamamoto, Takuo Yasunaga, Hiroshi Sakamoto. Conformational equilibrium of NADPH-cytochrome P450 oxidoreductase is essential for heme oxygenase reaction. Antioxidants. 2020. 9. 8. 1-13
Masakazu Sugishima, Hideaki Sato, Kei Wada, Ken Yamamoto. Crystal structure of a NADPH-cytochrome P450 oxidoreductase (CYPOR) and heme oxygenase 1 fusion protein implies a conformational change in CYPOR upon NADPH/NADP⁺ binding. FEBS Letters. 2019. 593. 8. 868-875
Haruna Takao, Kei Hirabayashi, Yuki Nishigaya, Haruna Kouriki, Tetsuko Nakaniwa, Yoshinori Hagiwara, Jiro Harada, Hideaki Sato, Toshimasa Yamazaki, Yoichi Sakakibara, et al. A substrate-bound structure of cyanobacterial biliverdin reductase identifies stacked substrates as critical for activity. Nature Communications. 2017. 8. 14397-14397
Yoshinori Hagiwara, Kei Wada, Teppei Irikawa, Hideaki Sato, Masaki Unno, Ken Yamamoto, Keiichi Fukuyama, Masakazu Sugishima. Atomic-resolution structure of the phycocyanobilin:ferredoxin oxidoreductase I86D mutant in complex with fully protonated biliverdin. FEBS Letters. 2016. 590. 19. 3425-3434

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MISC (14)：

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Lectures and oral presentations (85)：

HO-CPR人工融合タンパク質の結晶構造
(日本結晶学会年会講演要旨集 2018)
基質を2分子結合したヒドロキシメチルビラン合成酵素のX線結晶構造解析
(日本蛋白質科学会年会プログラム・要旨集 2018)
基質2分子を結合したヒドロキシメチルビランシンターゼの結晶構造解析
(日本化学会春季年会講演予稿集(CD-ROM) 2018)
癌代謝物である2-ヒドロキシグルタル酸がヒト由来ペプチドC末端アミド化酵素PAMに与える影響
(生命科学系学会合同年次大会 2017)
癌代謝物である2-ヒドロキシグルタル酸がヒト由来ペプチドC末端アミド化酵素PAMに与える影響
(日本生化学会大会(Web) 2017)

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Professional career (1)：

博士(理学) (東北大学)

Awards (1)：

2000/06 - (The American Society for Biochemistry and Molecular Biology & the American Society for Pharmacology and Experimental Therapeutics Joint Meeting 2000) ASBMB Graduate/Postdoctoral Travel Award

Association Membership(s) (4)：

日本蛋白質科学会 , 日本化学会生体機能関連化学部会 , 日本生化学会 , 日本化学会

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