Manabu Niimi

ニイミマナブ | Manabu Niimi

Affiliation and department：
Job title： Assistant Professor

Research field (2)： Experimental pathology , Pathobiochemistry

Research keywords (7)： Arteriosclerosis , Atherosclerosis , Lipoprotein metabolism , Dyslipidemia , Hyperlipidemia , Knockout rabbits , Transgenic rabbits

Research theme for competitive and other funds (7)：

2023 - 2027 Effects of ANGPTLs on dyslipidemia and atherosclerosis: analysis using gene-modified rabbits.
2023 - 2026 Elucidation of IDOL inhibition effects on hyperlipidemia and atherosclerosis using KO rabbits
2023 - 2026 Elucidation of the pathogenesis of aortic disease and organ damage by angioscopy using a genetically modified rabbit model
2020 - 2023 Functions of apo A-V in atherosclerosis: a study of knockout rabbit model
2017 - 2020 Function of apoE in lipoprotein metabolism and atherosclerosis: insight from apoE-deficient rabbit model

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Papers (40)：

Niimi M, Fan J. Inflammatory reactions in the pathogenesis of atherosclerosis -An update. Pathology and Clinical Medicine. 2024. 42. 9. 899-908
Niimi M, Chen Y, Zhao H, Tang X, Matsuhisa F, Zhou H, Yan H, Chen L, Kitajima S, Sato A, et al. Enhanced Atherosclerosis in Apolipoprotein E Knockout Rabbits: Role of ApoB48-Rich Remnant Lipoproteins. Front Cardiovasc Med. 2024. 11. 1424064
Sui Y, Jiang R, Niimi M, Wang X, Xu Y, Zhang Y, Shi Z, Suda M, Mao Z, Fan J, et al. Gut bacteria exacerbates TNBS-induced colitis and kidney injury through oxidative stress. Redox Biol. 2024. 72. 103140
Chen Y, Niimi M, Zhang L, Tang X, Lu J, Fan J. A Simple Telemetry Sensor System for Monitoring Body Temperature in Rabbits-A Brief Report. Animals. 2023. 13. 10. 1677-1677
Jiang R, Sui Y, Hong JNiimi M, Yan Q, Shi Z, Yao J. The Combined Administration of Vitamin C and Copper Induces a Systemic Oxidative Stress and Kidney Injury. Biomolecules. 2023. 13. 1. 143-143

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Patents (2)：

Method of measuring cholesterol in remnant-like lipoproteins
High density lipoprotein-reactive peptides

Books (1)：

Atherosclerosis: Methods and Protocols
Springer Nature 2022 ISBN:9781071619230

Lectures and oral presentations (57)：

A novel model for studying hypertriglyceridemia: Apo A-V knockout rabbits
(The 9th International Congress of Rabbit Biotechnology and Large Animal Models for Translational Research 2024)
IDOL deficiency inhibits cholesterol-rich diet-induced atherosclerosis in rabbits
(The 9th International Congress of Rabbit Biotechnology and Large Animal Models for Translational Research 2024)
Enhanced atherosclerosis in apoE knockout rabbits: Role of apoB48-rich remnant lipoproteins
(The 8th China-Canada International Symposium in Atherosclerosis and Cardiovascular Diseases 2024)
Pathological investigations of intracranial atherosclerosis using multiple hypercholesterolemic rabbit models
(The International Conference on Animal Models for Cardiovascular Disease 2023 2023)
Hyperlipidemic rabbit models for the study of atherosclerotic disease
(The International Conference on Animal Models for Cardiovascular Disease 2023 2023)

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Education (3)：

- 2014 University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering Department of Human Environment Medical Engineering
- 1996 Niigata University Graduate School of Science Department of Biology
- 1994 Niigata University Faculty of Science Department of Biology

Professional career (2)：

Ph. D.
MSc

Work history (4)：

2021 - 現在 University of Yamanashi Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine Assistant Professor
2019 - 2021 University of Yamanashi Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine Assistant Professor
2017 - 2019 University of Yamanashi Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine Assistant Professor
2012 - 2017 University of Yamanashi Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine Research Assistant Professor

Committee career (2)：

2018 - 現在 Japan Rabbit Bioscience Association Board of Director
2016 - 現在 Japan Atherosclerosis Society Councilor

Association Membership(s) (7)：

Japan Rabbit Bioscience Association , Japanese Association for Laboratory Animal Science , The Japanese Society of Pathology , The Japanese Biochemical Society , American Heart Association , European Atherosclerosis Society , Japan Atherosclerosis Society

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