Hideki Yoshida

ヨシダヒデキ | Hideki Yoshida

Affiliation and department：

Research field (5)： Fetal medicine/Pediatrics , Tumor diagnostics and therapeutics , Tumor biology , Tumor biology , Tumor diagnostics and therapeutics

Research keywords (5)：細胞療法 , Virotherapy , Oncology , Hematology , Pediatrics

Research theme for competitive and other funds (20)：

2023 - 2026 Development of gene cell therapy using mesenchymal stromal cells for neuroblastoma
2023 - 2026 Development of gene cell therapy using mesenchymal stromal cells for neuroblastoma
2023 - 2026 Development of novel gene therapy for rhabdomyosarcoma
2023 - 2026 WT1プロモーター制御性ウイルスによる小児悪性固形腫瘍に対する新たな治療戦略
2022 - 2025 Characterization of PLAGL1-FOXO1 fusion gene in alveolar rhabdomyosarcoma

2021 - 2024 Liquid biopsy for Rhabdoid tumor by Exoxomal-microRNAs in blood and other body fluids

2022 - 2023 小児急性骨髄性白血病(AML)および骨髄増殖性疾患(MPN)におけるALK/ROS1融合遺伝子の臨床的意義の検討

2020 - 2023 神経芽腫の自然退縮・分化に関わる新規予後良好分子マーカーの検討と治療応用

2020 - 2023 鶏卵漿尿膜法を利用した横紋筋肉腫組織移植3Dモデルの作成

2020 - 2023 固形腫瘍の腫瘍微小環境改善を目指した複合的遺伝子改変T細胞療法の開発

2020 - 2023 Development of CAR-T cell therapy complementary system for rhabdomyosarcoma using oncolytic virus

2020 - 2023 CD19発現型AdVとCD19 CAR-T細胞を組み合わせた遺伝子細胞治療戦略英文

2022 - 複数回の造血幹細胞移植を実施した小児急性骨髄性白血病難治例を対象とした、1治療成績と予後因子の検討 2緩和ケアの評価および体制整備の充実に向けた検討

2020 - 2022 Rhabdoid tumorに対する新規腫瘍溶解性アデノウイルス製剤の開発

2019 - 2021 Development of oncolytic adenovirus with costimulatory factor, contributing to suppress CAR-T cell exhaustion

2018 - 2020 MYOG Promoter-Controlled Oncolytic Adenovirus to Treat PAX3-FOXO1- Positive Rhabdomyosarcoma

2015 - 2017 Development of the new treatment for ETP-ALL

2014 - 2015 The Prospects of the Novel strategy for cancer treatment using the immunological technique

2013 - 2014 Cytogenetic Diagnosis of Lipoblastoma using PLAG1 Expression Analysis

2012 - 2013 Development of the microresidual disease marker using cancer-specific micro RNA

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Papers (38)：

Hideki Yoshida, Shotaro Iwamoto, Akira Shimada, Takako Miyamura, Kiminori Terui, Hirozumi Sano, Akihiro Tamura, Yoko Mizoguchi, Kyoko Moritani, Toshihiko Imamura, et al. Multiple Hematopoietic Stem Cell Transplantations in Pediatric Acute Myeloid Leukemia: Prognostic Significance of Remission and Severe Sinusoidal Obstruction Syndrome. Pediatric Blood & Cancer. 2025
Satoru Oya, Hideki Yoshida, Akimasa Tomida, Mitsuru Miyachi, Shigeki Yagyu, Yoshiki Katsumi, Ken Kikuchi, Kunihiko Tsuchiya, Eiichi Konishi, Subbaya Subramanian, et al. A Novel Conditionally Replicative Oncolytic Adenovirus under the Control of the SALL4 Promoter Inhibits the Growth of Rhabdoid Tumors. Molecular Cancer Therapeutics. 2025
Kohei Mitsuno, Masaya Suematsu, Yuki Naito, Azusa Mayumi, Hideki Yoshida, Shinya Osone, Toshihiko Imamura, Yozo Nakazawa, Shigeki Yagyu, Tomoko Iehara. Selective JAK2 pathway inhibition enhances anti-leukemic functionality in CD19 CAR-T cells. Cancer immunology, immunotherapy : CII. 2025. 74. 3. 79-79
Hiroaki Kondo, Ken Kikuchi, Akimasa Tomida, Hideki Yoshida, Mitsuru Miyachi, Yoshiki Katsumi, Shigeki Yagyu, Kunihiko Tsuchiya, Tomoko Iehara. Identifying miRNAs as predictive markers of good prognosis in neuroblastoma. Pediatrics international : official journal of the Japan Pediatric Society. 2025. 67. 1. e70154
Hiroyuki Ishida, Katsutsugu Umeda, Kana Matsumoto, Hirotoshi Sakaguchi, Hideki Yoshida, Kunihiko Morita, Hiromasa Yabe. Pharmacokinetics of melphalan and adverse events in pediatric AML patients receiving a uniform conditioning regimen. Pediatrics international : official journal of the Japan Pediatric Society. 2025. 67. 1. e70080

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MISC (44)：

丹羽優花, 富田晃正, 吉田秀樹, 宮地充, 土屋邦彦, 家原知子. 悪性腫瘍との鑑別を要した肝rapidly involuting congenital hemangioma(RICH)の1例. 近畿小児科学会プログラム・抄録集. 2025. 38th
池村高明, 菊地顕, 富田晃正, 吉田秀樹, 宮地充, 勝見良樹, 土屋邦彦, 家原知子. Investigation of PDX modeling of pediatric solid tumor using chick chorioallantonic membrane (CAM) assay. 日本小児科学会雑誌. 2025. 129. 2
Yuya Sugitatsu, Akimasa Tomida, Hideki Yoshida, Mitsuru Miyachi, Ken Kikuchi, Kunihiko Tsuchiya, Tomoko Iehara. EML4-ALK FUSION GENE-POSITIVE EMBRYONAL RHABDOMYOSARCOMA REFRACTORY TO CHEMOTHERAPY AND RADIOTHERAPY. PEDIATRIC BLOOD & CANCER. 2024. 71. S35-S35
SUGITATSU Yuya, MIYACHI Mitsuru, TOMIDA Akimasa, YOSHIDA Hideki, TSUCHIYA Kunihiko, AIBE Norihiro, TONOMURA Hitoshi, FUMINO Shigehisa, UMEBAYASHI Daisuke, YAMANAKA Takumi, et al. Primary atypical teratoid rhabdoid tumor of the spinal cord presenting with a dumbbell-shaped mass: A report of three cases. 日本小児血液・がん学会雑誌(Web). 2024. 61. 4
富田晃正, 宮地充, 吉田秀樹, 長谷川龍志, 池田和幸, 土屋邦彦, 宮澤真由美, 安田美緒, 辻尾有利子, 松尾惠美, et al. Implement and practice of advance care planning sheet for pediatric patients. 日本小児科学会雑誌. 2024. 128. 2

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Lectures and oral presentations (25)：

複数回移植を受けた小児急性骨髄性白血病症例に対する終末期ケア・協働意思決定の検討
(第47回日本造血・免疫細胞療法学会総会 2025)
複数回移植を受けた小児急性骨髄性白血病患者の予後因子
(第66回日本小児血液・がん学会学術集会 2024)
Development of Oncolytic Virotherapy for Pediatric Cancer
(第65回日本小児血液・がん学会 2023)
新規疾患概念の提案;ALK関連融合遺伝子とモノソミー7を有する骨髄増殖性腫瘍
(第85回日本血液学会 2023)
SALL4プロモーター制御性腫瘍溶解性アデノウイルスはin vitroおよびin vivoにおいてラブドイド腫瘍の増殖を抑制する
(第29回日本遺伝子細胞治療学会 2023)

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Education (2)：

2012 - 2016 Kyoto Prefectural University of Medicine Graduated school of Medical Science Department of Pediatrics
1998 - 2004 Kyoto Prefectural University of Medicine The Medical Faculty Department of Medicine

Professional career (2)：

MD (Kyoto prefectural university of medicine)
PhD (Kyoto prefectural university of medicine)

Work history (9)：

2025/07 - 現在 Kyoto Prefectural University of Medicine Department of Pediatrics Lecturer
2020/04 - 2025/06 Kyoto Prefectural University of Medicine Department of Pediatrics Assistant Professor
2019/04 - 2020/03 Kyoto Prefectural University of Medicine Professional Training Center in Cancer Medicine Assistant Professor
2016/04 - 2019/03 University of Minnesota Division of Basic and Translational Research, Department of Surgery Postdoctoral associate
2012/04 - 2016/03 North Medical Center, Kyoto Prefectural University of Medicine Department of Pediatrics Assistant head physician

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Committee career (4)：

2025/04 - 現在 Japan Children's Cancer Group (JCCG) Liver Tumor Comittee
2023/04 - 現在 Japan Children's Cancer Group (JCCG) Acute Myeloid Leukemia Committee
2020/04 - 現在 Japan Association of Childhood Leukemia Study (JACLS) Acute Myeloid Leukemia Sub-Committee
2023/04 - 2025/03 Japan Children's Cancer Group (JCCG) Brain Tumor Comittee

Awards (7)：

2022/11 - 公益信託日本白血病研究基金日本白血病研究基金小児領域特別研究賞「毎日賞」複数回の造血幹細胞移植を実施した小児急性骨髄性白血病難治例を対象とした、1治療成績と予後因子の検討 2緩和ケアの評価および体制整備の充実に向けた検討
2022/10 - 公益財団法人がんの子どもを守る会治療研究助成金小児急性骨髄性白血病(AML)および骨髄増殖性疾患(MPN)におけるALK/ROS1融合遺伝子の臨床的意義の検討
2021/11 - ENT M Dr.浅野登&暉子基金「ENT M Dr.浅野登&暉子基金」医学基礎研究助成奨励金ラブドイド腫瘍に対する新規ウイルス療法の開発
2019/05 - American Society of Gene & Cell Therapy Travel Award, 22st Annual Meeting of ASGCT AdMG-MYOGp(S)-E1-5/3F, MYOG promoter-controlled oncolytic adenovirus, selectively kills rhabdomyosarcoma cells
2014/11 - Japanese Society of Pediatric Hematology / Oncology Best Poster Award, 56th Congress of JPHO Analysis of the risk factors for hyperglycemia related to L-asparaginase in the patients with ALL registered

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Association Membership(s) (7)：

日本遺伝子細胞治療学会 , Japan Society of Clinical Oncology , THE JAPANESE CANCER ASSOCIATION , Jpanese Society for Transplantation and Cellular Therapy , THE JAPANESE SOCIETY OF PEDIATRIC HEMATOLOGY/ONCOLOGY , THE JAPANESE SOCIETY OF HEMATOLOGY , JAPAN PEDIATRIC SOCIETY

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