Rchr
J-GLOBAL ID：201901001412433507
Update date: Dec. 12, 2024
Yamaguchi Kosuke
ヤマグチ コウスケ | Yamaguchi Kosuke
Affiliation and department：
Job title：
Assistant Professor
Research field (1)：
Genomics
Research keywords (7)：
DNA replication
, DNMT1
, UHRF1
, DNM methylation
, Epigenetics
, ChIP-seq
, Histone
Research theme for competitive and other funds (5)：
- 2024 - 2026 発生・分化過程における複製開始領域、エピゲノム情報、転写活性の相関性の解明
- 2022 - 2024 The controlled epigenetic disturbances after UHRF1/ DNMT1 removal
- 2022 - 2022 Controlled epigenetic disturbances induce the senescence in cancer cells
- 2019 - 2022 Comprendre et cibler un oncogène épigénétique humain, UHRF1.
- 2017 - 2019 Re-evaluation of the localization of sperm retained histones by using Nucleoplasmin
Papers (16)：
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Xiaoying Chen, Kosuke Yamaguchi, Brianna Rodgers, Delphine Goerhig, David Vindrieux, Xavier Lahaye, Matthieu Nolot, Laure Ferry, Pierre Dubus, Fumihito Miura, et al. DNA methylation protects cancer cells against non-canonical senescence. 2024
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Jumpei Fujiki, Naoyuki Maeda, Kosuke Yamaguchi, Yuya Ohtsuki, Hidetomo Iwano. DNA methylation of Ad4BP/SF-1 suppresses Cyp11a1 and StAR transcripts in C2C12 myoblasts. Molecular and cellular endocrinology. 2024. 593. 112336-112336
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Kosuke Yamaguchi, Xiaoying Chen, Brianna Rodgers, Fumihito Miura, Pavel Bashtrykov, Frédéric Bonhomme, Catalina Salinas-Luypaert, Deis Haxholli, Nicole Gutekunst, Bihter Özdemir Aygenli, et al. Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells. Nature Communications. 2024
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Lounis Yakhou, Anaelle Azogui, Nikhil Gupta, Julien Richard Albert, Fumihito Miura, Laure Ferry, Kosuke Yamaguchi, Sarah Battault, Pierre Therizols, Frédéric Bonhomme, et al. A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation. Nucleic acids research. 2023
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Nikhil Gupta, Lounis Yakhou, Julien Richard Albert, Anaelle Azogui, Laure Ferry, Olivier Kirsh, Fumihito Miura, Sarah Battault, Kosuke Yamaguchi, Marthe Laisné, et al. A genome-wide screen reveals new regulators of the 2-cell-like cell state. Nature Structural & Molecular Biology. 2023
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Books (1)：
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実験医学増刊 Vol. 36, No. 17
羊土社 2018
Lectures and oral presentations (21)：
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Transient and prolonged epigenetic disturbances: effect on cell identity and transformation
(Labex WHO AM I? Exploring identity: from molecules to individuals 2022)
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Time resolved multi-omic analyses reveal new UHRF1 functions.
(6th Max Planck Epigenetics Meeting 2022)
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Controlled epigenetic disturbances induce the senescence in cancer cells
(The 15th annual meeting of the Japanese society for epiegenetics 2022)
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AID system revealed UHRF1/ DNMT1 specific functions in colorectal cancer cells for cell cycle and epigenetics state maintenance.
(25èmes Journées Jeunes Chercheurs de la Fondation ARC 2021 2021)
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Controlled epigenetic disturbances induce the cellular senescence in colorectal cancer cells
(8th New Academic Area "Non-Genome Information Replication" Webinar 2021)
ｍore...
Education (2)：
- 2015 - 2019 University of Tokyo Graduate School of Arts and Sciences Department of Life Sciences
- 2009 - 2015 Rakuno Gakuen University The faculty of Veterinary Medicine Department of Veterinary Medicine
Professional career (1)：
Work history (4)：
- 2024/04 - 現在 National Institute of Genetics Kanemaki Lab, Department of Chromosome Science Assistant Professor
- 2019/05 - 2024/03 Unité Epigénétique et Destin Cellulaire UMR 7216 Defossez PA team Post doctoral fellow
- 2019/03 - 2019/04 The University of Tokyo Institute of Quantitative Biology Post doctoral fellow
- 2015/04 - 2015/08 Institute of Molecular and Cellular Biosciences (Institute for Quantitative Biosciences), the University of Tokyo Laboratory of Pathology and Development Fellow
Awards (4)：
- 2021/09 - 164th Annual Meeting of the Japanese Society of Veterinary Medicine Physiology / Biochemistry Subcommittee Encouragement Award
- 2018/09 - Platform of Advanced Animal Model Support FY2018 Technical Training Course for the youth, best poster award
- 2015/03 - Hokkaido Veterinary Association Hokkaido Veterinary Association Award
- 2014/10 - The Japanese Biochemical Society The 87th Japan Biochemical Conference, excellent presentation award for young scientists
Association Membership(s) (3)：
日本獣医学会
, The Japanese Society for Epigenetics
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
