Tsuchida Akiko

Affiliation and department：

Research keywords (2)： Cancer , Glycobiology

Research theme for competitive and other funds (4)：

2011 - 2013 Roles of branched-type disialyl- antigen in malignant conversion in renal cell cancer
2009 - 2011 腎癌における分岐型ジシアリル糖鎖の作用機序と治療応用の基礎的検討
2007 - 2009 腎癌の悪性形質におけるジシアリル糖鎖の作用機構と治療応用の基礎的検討
2005 - 2007 腎癌の悪性度を制御するDisialyl糖鎖の合成機構と機能の解明

Papers (13)：

Noboru Hashimoto, Shizuka Ito, Akiko Tsuchida, Robiul H Bhuiyan, Tetsuya Okajima, Akihito Yamamoto, Keiko Furukawa, Yuhsuke Ohmi, Koichi Furukawa. The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid-binding lectin SIGLEC7 on the cell surface. The Journal of biological chemistry. 2019. 294. 28. 10833-10845
Akiko Tsuchida, Motohiro Senda, Akihiro Ito, Seiichi Saito, Makoto Kiso, Takayuki Ando, Anne Harduin-Lepers, Akio Matsuda, Keiko Furukewa, Koichi Furukawa. Roles of GalNAc-disialyl Lactotetraosyl Antigens in Renal Cancer Cells. Scientific Reports. 2018. 8. 1. 7017
Goto K, Ideo H, Tsuchida A, Hirose Y, Maruyama I, Noma S, Shirai T, Amano J, Mizuno M, Matsuda A. Synthesis of 1,5-Anhydro-d-fructose derivatives and evaluation of their inflammasome inhibitors. Bioorganic & medicinal chemistry. 2018. 26. 13. 3763-3772
Yasuyuki Matsumoto, Qing Zhang, Kaoru Akita, Hiroshi Nakada, Kazunori Hamamura, Akiko Tsuchida, Tetsuya Okajima, Koichi Furukawa, Keiko Furukawa, Takeshi Urano. Trimeric Tn antigen on syndecan 1 produced by ppGalNAc-T13 enhances cancer metastasis via a complex formation with integrin α5β1 and matrix metalloproteinase 9. Journal of Biological Chemistry. 2013. 288. 33. 24264-24276
Yasuyuki Matsumoto, Qing Zhang, Kaoru Akita, Hiroshi Nakada, Kazunori Hamamura, Noriyo Tokuda, Akiko Tsuchida, Takeshi Matsubara, Tomoko Hori, Tetsuya Okajima, et al. pp-GalNAc-T13 induces high metastatic potential of murine Lewis lung cancer by generating trimeric Tn antigen. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2012. 419. 1. 7-13

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Patents (11)：

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Books (2)：

Experimental Glycoscience, Glycobiology
Springer 2008
Comprehensive glycoscience. From Chemistry to Systems Biology.
Elsevier 2007

Work history (4)：

2007/04 - 現在公財)野口研究所研究員
2002/11 - 2007/03 Nagoya University Graduate School of Medicine
2001/12 - 2002/11 名古屋大学生物分子応答研究センター研究機関研究員
1999/04 - 2001/11 日本学術振興会特別研究員(PD)

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