Rchr
J-GLOBAL ID：201901001455571318
Update date: Apr. 05, 2024
Shimonaka Shotaro
シモナカ ショウタロウ | Shimonaka Shotaro
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Affiliation and department：
Tokyo Metropolitan Institute of Medical Science
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Research field (1)：
Pathobiochemistry
Research theme for competitive and other funds (3)：
2023 - 2026 Tauopathyにおける構造多型に着目したtau凝集の特異的阻害法開発
2020 - 2023 各種Tauopathyにおいて特異的な凝集体を形成するtau単位配列の役割解明
2017 - 2021 The role of Alzheimer's disease risk factor PICALM on the propagation of Tau aggregates
Papers (9)：
Kensuke Daida, Shotaro Shimonaka, Kahori Shiba-Fukushima, Jun Ogata, Hiroyo Yoshino, Ayami Okuzumi, Taku Hatano, Yumiko Motoi, Tomoki Hirunagi, Masahisa Katsuno, et al. α-Synuclein V15A Variant in Familial Parkinson's Disease Exhibits a Weaker Lipid-Binding Property. Movement disorders : official journal of the Movement Disorder Society. 2022. 37. 10. 2075-2085
Montasir Elahi, Yumiko Motoi, Shotaro Shimonaka, Yoko Ishida, Hiroyuki Hioki, Masashi Takanashi, Koichi Ishiguro, Yuzuru Imai, Nobutaka Hattori. High-fat diet-induced activation of SGK1 promotes Alzheimer's disease-associated tau pathology. Human molecular genetics. 2021. 30. 18. 1693-1710
Mohammad Nasir Uddin, Montasir Elahi, Shotaro Shimonaka, Soichiro Kakuta, Koichi Ishiguro, Yumiko Motoi, Nobutaka Hattori. Strain-specific clearance of seed-dependent tau aggregation by lithium-induced autophagy. Biochemical and biophysical research communications. 2021. 543. 65-71
Jun Ogata, Daisaku Takemoto, Shotaro Shimonaka, Yuzuru Imai, Nobutaka Hattori. α-Synuclein Seeding Assay Using Cultured Cells. Methods in molecular biology (Clifton, N.J.). 2021. 2322. 27-39
Tetsuo Hayashi, Shotaro Shimonaka, Montasir Elahi, Shin-Ei Matsumoto, Koichi Ishiguro, Masashi Takanashi, Nobutaka Hattori, Yumiko Motoi. Learning Deficits Accompanied by Microglial Proliferation After the Long-Term Post-Injection of Alzheimer's Disease Brain Extract in Mouse Brains. Journal of Alzheimer's disease : JAD. 2021. 79. 4. 1701-1711
ｍore...
MISC (4)：
林 徹生, 本井 ゆみ子, 下中 翔太朗, モンタシル・エラヒ, 服部 信孝. タウ蛋白伝播モデルマウスにおける行動および組織学的解析. Dementia Japan. 2018. 32. 3. 432-432
Nakayama Sachiko, Shimonaka Shotaro, Elahi Montasir, Oji Yutaka, Li Yuanzhe, Hiroyo Yoshino, Nishioka Kenya, Hatano Taku, Motoi Yumiko, Hattori Nobutaka. 新規MAPT遺伝子変異 臨床的および生化学的解析(New Mutations in the MAPT Gene: Clinical and Biochemical Characterization). 順天堂醫事雑誌. 2017. 63. 6. 489-490
本井 ゆみ子, 林 徹生, 下中 翔太郎, 服部 信孝. 認知症・治療の展望 タウ蛋白ターゲットの治療薬開発の展望 世界の動向と我々の視点. 神経治療学. 2017. 34. 6. S114-S114
下中 翔太郎, 松本 信英, 本井 ゆみ子, 服部 信孝. Tauopathy培養細胞モデルを用いたTauの凝集・伝播に関わるアミノ酸配列の同定. Dementia Japan. 2017. 31. 4. 553-553
Lectures and oral presentations (3)：
Tau-strainを区別する人工変異導入tauが持つ 凝集阻害効果の検証
(第42回日本認知症学会学術集会 2023)
The molecular pathology of tau strain and anti-aggregation strategy
(2023)
Tau-strainの分子病理と凝集阻害戦略
(第41回日本認知症学会学術集会/第37回日本老年精神医学会 (合同開催) 2022)
Awards (1)：
2023/11 - 日本認知症学会 第42回日本認知症学会学術集会 学会奨励賞 (基礎研究部門) Tau-strainを区別する人工変異導入tauが持つ 凝集阻害効果の検証
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