Rchr
J-GLOBAL ID:201901001569565202   Update date: Jan. 31, 2024

Ohtake Fumiaki

オオタケ フミアキ | Ohtake Fumiaki
Affiliation and department:
Homepage URL  (1): https://polaris.hoshi.ac.jp/kyoshitsu/bunkai/index.html
Research field  (1): Functional biochemistry
Research keywords  (4): Signal Transduction ,  Proteomics ,  Ubiquitin ,  Protein Degradation
Research theme for competitive and other funds  (15):
  • 2021 - 2025 Elucidating the role of branched ubiquitin code
  • 2018 - 2023 Decryption of the ubiquitin code by chemo-technologies and advanced proteomics
  • 2020 - 2022 翻訳後修飾によらないユビキチンの新機能
  • 2017 - 2021 Elucidating the role of branched ubiquitin code
  • 2016 - 2019 Construction of quantitative reporter system for branched ubiquitin chains
Show all
Papers (28):
  • Tomohiro Iriki, Hiroaki Iio, Shu Yasuda, Shun Masuta, Masakazu Kato, Hidetaka Kosako, Shoshiro Hirayama, Akinori Endo, Fumiaki Ohtake, Mako Kamiya, et al. Senescent cells form nuclear foci that contain the 26S proteasome. Cell reports. 2023. 112880-112880
  • Yoshino Akizuki, Mai Morita, Yuki Mori, Ai Kaiho-Soma, Shivani Dixit, Akinori Endo, Marie Shimogawa, Gosuke Hayashi, Mikihiko Naito, Akimitsu Okamoto, et al. cIAP1-based degraders induce degradation via branched ubiquitin architectures. Nature chemical biology. 2022. 19. 3. 311-322
  • Sonya Neal, Fumiaki Ohtake, Ana Maria Cuervo, Ramanujan S Hegde, Ursula Jakob, Michael Lazarou, Wendy V Gilbert, Zhijian J Chen, Sharon A Tooze, James E Haber, et al. Quality Control: Maintaining molecular order and preventing cellular chaos. Molecular cell. 2022. 82. 8. 1390-1397
  • Fumiaki Ohtake. Branched ubiquitin code: from basic biology to targeted protein degradation. Journal of biochemistry. 2022. 171. 4. 361-366
  • Yifan Huang, Hiromasa Yokoe, Ai Kaiho-Soma, Kazunori Takahashi, Yusuke Hirasawa, Hiroshi Morita, Fumiaki Ohtake, Naoki Kanoh. Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation. Bioconjugate chemistry. 2022. 33. 1. 142-151
more...
MISC (8):
Lectures and oral presentations  (9):
  • Role of the branched ubiquitin chains in targeted protein degradation
    (Cold Spring Harbor Laboratory Meeting 「Ubiquitins, autophagy and diseases」 2023)
  • 標的タンパク質分解誘導剤によるネオユビキチンコード形成機構
    (第95回日本生化学会大会シンポジウム「ユビキチン・プロテアソーム研究のニューフロンティア」 2022)
  • Branched ubiquitin chains promote chemically-induced targeted protein degradation,
    (第44回日本分子生物学会年会 “Breakthroughs in the ubiquitin research accelerated by chemo-technologies” 2021)
  • 標的タンパク質分解薬におけるユビキチン分岐鎖と役割
    (第40回日本認知症学会学術集会(オンデマンド配信、オンラインシンポジウム) 2021)
  • 化合物による標的タンパク質分解を誘導するユビキチンコード
    (第94回日本生化学大会シンポジウム「躍動するユビキチンコード研究」 2021)
more...
Professional career (1):
  • 博士(農学) (東京大学)
Work history (3):
  • 2020/04 - 現在 公益財団法人東京都医学総合研究所 客員研究員
  • 2019/12 - 現在 Hoshi University
  • 2016/04 - 2019/11 Tokyo Metropolitan Institute of Medical Science
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page