Ohtake Fumiaki

オオタケフミアキ | Ohtake Fumiaki

Affiliation and department：
Homepage URL (1)： https://polaris.hoshi.ac.jp/kyoshitsu/bunkai/index.html

Research field (1)： Functional biochemistry

Research keywords (4)： Signal Transduction , Proteomics , Ubiquitin , Protein Degradation

Research theme for competitive and other funds (15)：

2021 - 2025 Elucidating the role of branched ubiquitin code
2018 - 2023 Decryption of the ubiquitin code by chemo-technologies and advanced proteomics
2020 - 2022 翻訳後修飾によらないユビキチンの新機能
2017 - 2021 Elucidating the role of branched ubiquitin code
2016 - 2019 Construction of quantitative reporter system for branched ubiquitin chains

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Papers (31)：

Yuki Mori, Yoshino Akizuki, Rikuto Honda, Miyu Takao, Ayaka Tsuchimoto, Sota Hashimoto, Hiroaki Iio, Masakazu Kato, Ai Kaiho-Soma, Yasushi Saeki, et al. Intrinsic signaling pathways modulate targeted protein degradation. Nature communications. 2024. 15. 1. 5379-5379
Yukiko Takeda, Masahiro Ueki, Junpei Matsuhiro, Erik Walinda, Takayuki Tanaka, Masafumi Yamada, Hiroaki Fujita, Shunichiro Takezaki, Ichiro Kobayashi, Sakura Tamaki, et al. A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome. The Journal of experimental medicine. 2024. 221. 6
Akinori Endo, Toshiaki Fukushima, Chikage Takahashi, Hikaru Tsuchiya, Fumiaki Ohtake, Sayaka Ono, Tony Ly, Yukiko Yoshida, Keiji Tanaka, Yasushi Saeki, et al. USP8 prevents aberrant NF-κB and Nrf2 activation by counteracting ubiquitin signals from endosomes. Journal of Cell Biology. 2024. 223. 3
Tomohiro Iriki, Hiroaki Iio, Shu Yasuda, Shun Masuta, Masakazu Kato, Hidetaka Kosako, Shoshiro Hirayama, Akinori Endo, Fumiaki Ohtake, Mako Kamiya, et al. Senescent cells form nuclear foci that contain the 26S proteasome. Cell reports. 2023. 112880-112880
Yoshino Akizuki, Mai Morita, Yuki Mori, Ai Kaiho-Soma, Shivani Dixit, Akinori Endo, Marie Shimogawa, Gosuke Hayashi, Mikihiko Naito, Akimitsu Okamoto, et al. cIAP1-based degraders induce degradation via branched ubiquitin architectures. Nature chemical biology. 2022. 19. 3. 311-322

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MISC (8)：

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Lectures and oral presentations (9)：

Role of the branched ubiquitin chains in targeted protein degradation
(Cold Spring Harbor Laboratory Meeting 「Ubiquitins, autophagy and diseases」 2023)
標的タンパク質分解誘導剤によるネオユビキチンコード形成機構
(第95回日本生化学会大会シンポジウム「ユビキチン・プロテアソーム研究のニューフロンティア」 2022)
Branched ubiquitin chains promote chemically-induced targeted protein degradation,
(第44回日本分子生物学会年会 “Breakthroughs in the ubiquitin research accelerated by chemo-technologies” 2021)
標的タンパク質分解薬におけるユビキチン分岐鎖と役割
(第40回日本認知症学会学術集会(オンデマンド配信、オンラインシンポジウム) 2021)
化合物による標的タンパク質分解を誘導するユビキチンコード
(第94回日本生化学大会シンポジウム「躍動するユビキチンコード研究」 2021)

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Professional career (1)：

Work history (3)：

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