Rchr
J-GLOBAL ID：201901002290251425
Update date: Feb. 15, 2024
Sakaue Hiroaki
サカウエ ヒロアキ | Sakaue Hiroaki
Affiliation and department：
Research field (1)：
Nutrition and health science
Research keywords (3)：
加齢性疾患
, 老化
, D-アミノ酸
Research theme for competitive and other funds (4)：
- 2020 - 2024 皮膚バリア機能の維持・向上に対する遊離D-アミノ酸の役割
- 2019 - 2023 精神的健康増進を目指した太陽光による中枢作用の解明
- 2016 - 2020 Investigation of isomerization mechanism of aspartic acid involved in the development of cataract
- 2016 - 2016 白内障の病態解明を指向したD-アミノ酸含有タンパク質の新規合成方法の開発
Papers (19)：
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Katsuki Okuyama, Koji Mizuno, Keisuke Nittami, Hiroaki Sakaue, Takashi Sato. Molecular mechanisms of cyclic phosphatidic acid-induced lymphangiogenic actions in vitro. Microvascular research. 2022. 139. 104273-104273
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Koji Mizuno, Hiroaki Sakaue, Keita Kohsaka, Hidetomo Takeda, Nobukazu Hayashi, Takashi Sato. An increase in normetanephrine in hair follicles of acne lesions through the sympatho-adrenal medullary system in acne patients with anxiety. The Journal of dermatology. 2021. 48. 8. 1281-1285
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Jun Matsumoto, Su Nwe San, Masachika Fujiyoshi, Ayano Kawauchi, Natsumi Chiba, Ran Tagai, Ryoko Sanbe, Shiho Yanaka, Hiroaki Sakaue, Yoshinori Kato, et al. Effect of CYP3A5*3 genetic variant on the metabolism of direct-acting antivirals in vitro: a different effect on asunaprevir versus daclatasvir and beclabuvir. Journal of human genetics. 2020. 65. 2. 143-153
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Kanamoto T, Sakaue H, Kitaoka Y, Asaoka R, Tobiume K, Kiuchi Y. D-Alanine Is Reduced by Ocular Hypertension in the Rat Retina. Current Eye Research. 2019. 45. 4. 1-6
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San SN, Matsumoto J, Saito Y, Koike M, Sakaue H, Kato Y, Fujiyoshi M, Ariyoshi N, Yamada H. Minor contribution of CYP3A5 to the metabolism of hepatitis C protease inhibitor paritaprevir in vitro. Xenobiotica; the fate of foreign compounds in biological systems. 2019. 49. 8. 935-944
ｍore...
MISC (4)：
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奥山勝揮, 坂上弘明, 坂上弘明, 佐藤隆. 近赤外線による温度上昇は皮脂腺のMMP産生を増強する. 日本フォトダーマトロジー学会学術大会講演要旨集. 2023. 6th
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Suzuki Yui, Sakaue Hiroaki, Fujii Noriko. 3 Analysis of aspartyl isomers in skin protein by LC-MS(General Session,The 39^<th> Annual Meeting of the SSOEL-Japan Program). Viva origino. 2014. 42. 3-3
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Sakaue Hiroaki, Fujii Noriko. 19 Inversion of aspartyl residues in _γD-Crystallin from human cataract lens(Symposium 2,The 36^<th> annual meeting of the SSOEL-JAPAN (Abstracts)). Viva origino. 2011. 39. 19-19
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Yuhei Mori, Kenzo Aki, Tadatoshi Kinouchi, Takehiro Kawaguti, Masashi Kida, Hiroaki Sakaue, Noriko Fujii. Simultaneous racemization and glycation of amino acid residues in proteins in UVB irradiated skin. the First International Congress of D-Amino Acid Research. 2009
Books (3)：
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The Importance of the Idea of "Parachirality" in Life Science.
2017
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D-Amino acid residues in proteins related to aging and age-related diseases and a new analysis of the isomers in proteins.
2016
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Behaviors of Mutant Mice Lacking D-Amino-Acid Oxidase Activity.
2016
Education (2)：
- 2011 - 2014 Kyoto University
- 2009 - 2011 Kyoto University
Professional career (1)：
Work history (4)：
- 2021/04 - 現在 National Institute of Advanced Industrial Science and Technology
- 2017/04 - 2021/03 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
- 2016/04 - 2017/03 International University of Health and Welfare School of Pharmacy
- 2014/04 - 2016/03 International University of Health and Welfare School of Pharmacy
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