SASAKI Masato

Affiliation and department：

Research field (5)： Molecular biochemistry , Pharmaceuticals - health and biochemistry , Medical biochemistry , Cell biology , Molecular biology

Papers (27)：

Masato Sasaki, Kazuo Yamamoto, Takeshi Ueda, Hayato Irokawa, Kouki Takeda, Ryoya Sekine, Fumie Itoh, Yutaka Tanaka, Shusuke Kuge, Nobuyuki Shibata. One-carbon metabolizing enzyme ALDH1L1 influences mitochondrial metabolism through 5-aminoimidazole-4-carboxamide ribonucleotide accumulation and serine depletion, contributing to tumor suppression. SCIENTIFIC REPORTS. 2023. 13. 1. 13486
Masato Sasaki, Fumie Itoh, Nobuyuki Shibata. Effects of expression of the 10-formyltetrahydrofolate metabolizing enzyme ALDH1L1 on pyrimidine nucleotide synthesis and the salvage pathway. Fundamental Toxicological Sciences. 2023. 10. 6. 241-247
Masataka Kawakita, Taiki Oyama, Ikuma Shirai, Shuto Tanaka, Kotaro Akaki, Shinya Abe, Takuma Asahi, Guangwei Cui, Fumie Itoh, Masato Sasaki, et al. Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis. Communications Biology. 2021. 4. 1. 342-342
Yutaka Tanaka, Masato Sasaki, Fumie Ito, Toshio Aoyama, Michiyo Sato-Okamoto, Azusa Takahashi-Nakaguchi, Hiroji Chibana, Nobuyuki Shibata. Cooperation between ER stress and calcineurin signaling contributes to the maintenance of cell wall integrity in Candida glabrata. Fungal biology. 2018. 122. 1. 19-33
Takeshi Ueda, Yuichiro Nakata, Akiko Nagamachi, Norimasa Yamasaki, Akinori Kanai, Yasuyuki Sera, Masato Sasaki, Hirotaka Matsui, Zen-ichiro Honda, Hideaki Oda, et al. Propagation of trimethylated H3K27 regulated by polycomb protein EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016. 113. 37. 10370-10375

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MISC (12)：

The Cell Wall Mannan Changes to an Increased Structure of β-1,2 Linked Mannose Residues with Morphological Change from Yeast to Hyphal Form of the Pathogenic Yeast Candida dubliniensis. 2019. 66. 55-66
佐々木雅人. がんにおける生理活性代謝物の動態と分子機能解析:ALDH1L1/2活性とがん発生・進展機構の相関解析. 医科学応用研究財団研究報告(CD-ROM). 2017. 34. 189-194
田中大, 佐々木雅人, 伊藤文恵, 柴田信之. Isolation and Characterization of an Extracellular Beta-Galactofuranosidase from Aspergillus fumigatus. 東北医科薬科大学研究誌. 2016. 63. 71-81
Masato Sasaki. Epigenetic alterations and biological phenomena caused by mutation in an IDH gene. Seikagaku. 2016. 88. 3. 287-295
西尾美希, 河原康一, 佐々木雅人, 前濱朝彦, 佐々木雄彦, 三森功士, 森正樹, 鈴木聡. 細胞周期制御の破綻と疾患 1.核小体を起点としp53を制御する新規分子PICT1による細胞増殖制御機構. 実験医学. 2013. 31. 2. 257-264

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Lectures and oral presentations (43)：

アルデヒドデヒドロゲナーゼ1ファミリーメンバーL1発現HuH-7細胞におけるテトラヒドロ葉酸代謝とペントースリン酸経路の関連解析
(日本薬学会第144年会 2024)
酸化ストレスセンサーBAG1の欠損が心機能に与える影響の解析
(日本薬学会第144年会 2024)
分子コシャペロンBAG1による心肥大制御機構の解析
(第62回日本薬学会東北支部大会 2023)
Relationship between purine nucleotide analogue sensitivity and 10-formyltetrahydrofolate metabolizing enzyme expression in hepatocellular carcinoma cells.
(Forum2023 Pharmaceutical Health Sciences • Enviromental Toxicology 2023)
Expression of a 10-formyltetrahydorofolate-metabolizing enzyme affects mitochondrial respiration and 5-aminoimidazole-4-carboxamide ribonucleoside sensitivity
(The 50th Annual Meeting of the Japanese Society of Toxicology 2023)

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Professional career (1)：

医学博士 (東北大学)

Work history (5)：

2014/04 - 現在 Tohoku Medical and Pharmaceutical University Faculty of Pharmaceutical Sciences Associate Professor
2008/04 - 2014/03 The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network Postdoctoral Research Fellow
2006/10 - 2010/03 Akita University School of Medicine
2005/04 - 2006/09 Akita University Graduate School of Medicine
2004/04 - 2005/03 Tohoku University Institute of Development, Aging and Cancer

Association Membership(s) (5)：

The Japanese Society of Toxicology , The Molecular Biology Society of Japan , THE JAPANESE SOCIETY FOR MEDICAL MYCOLOGY , THE JAPANESE CANCER ASSOCIATION , THE PHARMACEUTICAL SOCIETY OF JAPAN

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