Research keywords (2)：
Ubiquitination
, DNA repair
Research theme for competitive and other funds (4)：
2017 - 2020 DNA複製とストレス応答におけるHERC2の機能解析
2014 - 2017 The Feature of BRCA1 function on DNA Damage Repair within higher-order chromatin structure
2011 - 2014 The role of BRCA1-HERC2 complex in DNA replication fork progression and stress response
2008 - 2011 A study on the molecular mechanisms of BRCA1-mediated cell cycle regulation from a comprehensive protein interaction analysis approach
Papers (37)：
Naoe T Nihira, Wenwen Wu, Mitsue Hosoi, Yukiko Togashi, Shigeaki Sunada, Yasuo Miyoshi, Yoshio Miki, Tomohiko Ohta. Nuclear PD-L1 triggers tumour-associated inflammation upon DNA damage. EMBO reports. 2025
Naoe Taira Nihira, Tomohiro Takeyama, Wenwen Wu, Tomohiko Ohta. The Potential Impact of BI-D1870, a Ribosomal S6 Kinase Inhibitor, on PD-L1 Expression Control. Journal of St. Marianna University. 2024. 15. 2. 45-52
Wenwen Wu, Jing Zhu, Naoe Taira Nihira, Yukiko Togashi, Atsushi Goda, Junki Koike, Kiyoshi Yamaguchi, Yoichi Furukawa, Takuya Tomita, Yasushi Saeki, et al. Ribosomal S6 kinase (RSK) plays a critical role in DNA damage response via the phosphorylation of histone lysine demethylase KDM4B. Breast cancer research. 2024. 26. 1. 146-146
Zhu J, Wu W, Togashi Y, Nihira NT, Johmura Y, Zhu D, Nakanishi M, Miyoshi Y, Ohta T. Alteration of Trop-2 expression in breast cancer cells by clinically used therapeutic agents and acquired tamoxifen resistance. Breast Cancer. 2022. Online ahead of print
Tencer AH, Liu J, Zhu J, Burkholder NT, Zhang Y, Wu W, Strahl BD, Ohta T, Kutateladze TG. The ZZ domain of HERC2 is a receptor of arginylated substrates. Sci Rep. 2022. 12. 6063
Ohta T, Wu W. Molecular Basis of BRCA1 and BRCA2: Homologous Recombination Deficiency and Tissue-Specific Carcinogenesis. Hereditary Breast and Ovarian Cancer(著書). 2021. 15-29
