Yokoyama Takeshi

ヨコヤマタケシ | Yokoyama Takeshi

Affiliation and department：
Other affiliations (4)：

Tohoku University Advanced Research Center for Innovations in Next-Generation Medicine
Tohoku University Faculty of Agriculture Department of Applied Biological Chemistry
Tohoku University
Japan Science and Technology Agency

Homepage URL (1)： https://www.lifesci.tohoku.ac.jp/research/teacher/detail.html?id=45539

Research field (2)： Structural biochemistry , Molecular biology

Research keywords (6)： ribosome , cryo-electron microscopy , single particle analysis , translation , RNA , macromolecular assembly

Research theme for competitive and other funds (13)：

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Papers (29)：

Naho Akiyama, Kensuke Ishiguro, Takeshi Yokoyama, Kenjyo Miyauchi, Asuteka Nagao, Mikako Shirouzu, Tsutomu Suzuki. Structural insights into the decoding capability of isoleucine tRNAs with lysidine and agmatidine. Nature Structural & Molecular Biology. 2024
Mayuki Tanaka, Takeshi Yokoyama, Hironori Saito, Madoka Nishimoto, Kengo Tsuda, Naoyuki Sotta, Hideki Shigematsu, Mikako Shirouzu, Shintaro Iwasaki, Takuhiro Ito, et al. Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1. Nature Chemical Biology. 2024
Junta Tomono, Kosuke Asano, Takuma Chiashi, Masato Suzuki, Masayuki Igarashi, Yoshiaki Takahashi, Yoshikazu Tanaka, Takeshi Yokoyama. Direct visualization of ribosomes in the cell-free system revealed the functional evolution of aminoglycoside. The Journal of Biochemistry. 2024
Xuewei Zhao, Ding Ma, Kensuke Ishiguro, Hironori Saito, Shinichiro Akichika, Ikuya Matsuzawa, Mari Mito, Toru Irie, Kota Ishibashi, Kimi Wakabayashi, et al. Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth. Cell. 2023. 186. 25. 5517-5535.e24
Hikaru Nakazawa, Taiji Katsuki, Takashi Matsui, Atsushi Tsugita, Takeshi Yokoyama, Tomoyuki Ito, Sakiya Kawada, Yoshikazu Tanaka, Mitsuo Umetsu. Synthesis of epitope-targeting nanobody based on native protein-protein interactions for FtsZ filamentation suppressor. Biotechnology journal. 2023. e2300039

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MISC (1)：

Tsubasa HASHIMOTO, Takeshi YOKOYAMA, Yoshikazu TANAKA. Actual Situation of Cryo-Electron Microscopy Single Particle Analysis; From Sample Preparation to Image Analysis. Nihon Kessho Gakkaishi. 2021. 63. 2. 89-96

Books (8)：

高分子 72(8)「クライオ電子顕微鏡で生体高分子を観る」
2023
「クライオ電子顕微鏡ハンドブック」第4章14節クライオ電子顕微鏡で見る、リボソームの「かたち」と「動き」
NTS 2023
顕微鏡 57(3)「透過型電子顕微鏡によるリボソームの構造解析、その歴史と今」
2023
Single particle cryo-EM of ribosomal complexes: visualization of how ribosome works in translation
2022
月刊「細胞」 53(14)「タンパク質合成装置リボソームを題材としたクライオ電子顕微鏡単粒子解析の概説」
2021

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Lectures and oral presentations (52)：

Sample preparation
(2024)
Cryo-electron microscopy visualizes gene expression mechanisms by ribosomes
(Mahidol University Seminar 2023)
INGEMクライオ電子顕微鏡施設を駆使した、リボソーム複合体のクライオ電子顕微鏡構造解析
(INGEM&ToMMoセミナーシリーズ第28回〜未来型医療の実現に向けた課題〜 2023)
リボソームを無細胞翻訳系内で「観察」し、抗菌薬の進化を解明する
(第23回日本蛋白質科学会年会、ワークショップ「高次構造体のはたらきを観る!」 2023)
Cryo-electron microscopy of ribosomal complexes to understand their roles in infectious diseases
(Seminar at Munster University 2023)

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Professional career (1)：

Committee career (5)：

Awards (2)：

2018/03 - RIKEN Center for Life Science Technologies CLST Researcher Incentive Award Structural analysis of various protein/ protein complexes by Cryo-EM
2018/03 - RIKEN RIKEN Research Incentive Award Structural analysis of various proteins/ protein complexes by Cryo-EM

Association Membership(s) (6)：

日本農芸化学会 , 日本生物物理学会 , 日本蛋白質科学会 , 日本分子生物学会 , THE RNA SOCIETY OF JAPAN , THE JAPANESE SOCIETY OF MICROSCOPY

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