Rchr
J-GLOBAL ID：201901003470001679   Update date: Nov. 26, 2024

Takahata Keisuke

タカハタ ケイスケ | Takahata Keisuke
Affiliation and department：
Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST) Advanced Neuroimaging Center

About Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST) Advanced Neuroimaging Center


Job title： Chief Researcher
Other affiliations (1)：
  • Keio University School of Medicine  Department of Neuropsychiatry 
Research field  (2)： Psychiatry ,  Neuroscience - general
Research keywords  (15)： CTE ,  Long COVID ,  tauopathy ,  organophosphate poisoning ,  cognitive impairment ,  late-life psychosis ,  Positron Emission Tomography (PET) ,  Neuropsychology ,  遅発性脳障害 ,  器質性精神障害 ,  Tau PET imaging ,  PET ,  Chronic Traumatic Encephalopathy ,  Punch-drunk syndrome, Dementia Pugilistica ,  Traumatic brain injury
Research theme for competitive and other funds  (14)：
  • 2024 - 2028 中枢神経損傷による続発性タウオパチーの病態解明
  • 2022 - 2027 タウ・アミロイドPETおよび7テスラMRI/MRSによる中高年期精神疾患の層別化
  • 2022 - 2025 スポーツ頭部外傷後遅発性脳障害に対するMRI・タウPETによる画像診断法の確立
  • 2021 - 2025 Investigation about underpinning neural mechanisms of sequelae and brain atrophy after brain injury
  • 2020 - 2024 治療抵抗性うつ病に対するMAOーB PET研究
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Papers (111)：
  • Yuki Momota, Shogyoku Bun, Jinichi Hirano, Kei Kamiya, Ryo Ueda, Yu Iwabuchi, Keisuke Takahata, Yasuharu Yamamoto, Toshiki Tezuka, Masahito Kubota, et al. Amyloid-β prediction machine learning model using source-based morphometry across neurocognitive disorders. Scientific Reports. 2024. 14. 1
  • Yugaku Daté, Shogyoku Bun, Keisuke Takahata, Masahito Kubota, Yuki Momota, Yu Iwabuchi, Toshiki Tezuka, Hajime Tabuchi, Morinobu Seki, Yasuharu Yamamoto, et al. Can the clinical sign "head-turning sign" and simple questions in "Neucop-Q" predict amyloid β pathology?. Alzheimer's research & therapy. 2024. 16. 1. 250-250
  • Hisaomi Suzuki, Kenji Tagai, Maiko Ono, Hiroshi Shimizu, Hironobu Endo, Hideki Matsumoto, Manabu Kubota, Yuko Kataoka, Sho Moriguchi, Shin Kurose, et al. Distinct tau pathologies in the nucleus basalis of Meynert between early-onset and late-onset Alzheimer's disease patients revealed by positron emission tomography. Journal of Alzheimer's disease : JAD. 2024. 13872877241297382-13872877241297382
  • Kenji Tagai, Harutsugu Tatebe, Sayo Matsuura, Zhang Hong, Naomi Kokubo, Kiwamu Matsuoka, Hironobu Endo, Asaka Oyama, Kosei Hirata, Hitoshi Shinotoh, et al. A novel plasma p-tau181 assay as a specific biomarker of tau pathology in Alzheimer's disease. Translational neurodegeneration. 2024. 13. 1. 44-44
  • Keisuke Takahata, Manabu Kubota, Shin Kurose, Makoto Higuchi. [Tau Positron Emission Tomography: Applications in Diagnosis and Prognosis of Various Diseases]. Brain and nerve = Shinkei kenkyu no shinpo. 2024. 76. 9. 1035-1044
ｍore...
MISC (143)：
  • 高畑 圭輔, 山田 遼佑. 【修正可能な認知症危険因子からのアプローチ】頭部外傷に関連する認知症 アルツハイマー病および慢性外傷性脳症. アンチ・エイジング医学. 2023. 19. 6. 500-504
  • 高畑 圭輔. 【認知症診療医が知っておくべき外傷性認知症に関する最新知見;症候,神経画像,急性期治療から生活支援,就労支援,バイオマーカーまで】中枢神経損傷によって引き起こされる続発性タウオパチー 慢性外傷性脳症. 老年精神医学雑誌. 2023. 34. 12. 1199-1206
  • 高畑 圭輔, 佐原 成人, 樋口 真人. 脳損傷を原因とする神経変性疾患の病理解明と組織修復を目指して 中枢神経損傷による続発性タウオパチー 長期病態と脳内タウ病変の可視化に向けた研究. Dementia Japan. 2023. 37. 4. 622-622
  • 宮田 真里, 高畑 圭輔, 鎌形 康司, 青木 茂樹, 遠藤 浩信, 互 健二, 森口 翔, 片岡 優子, 関 千江, 百田 友紀, et al. 元プロボクサーのMRIによるglymphatic systemの評価,血液マーカー,認知機能との関連. Dementia Japan. 2023. 37. 4. 654-654
  • 高畑 圭輔, 互 健二, 宮田 真里, 建部 陽嗣, 久保田 学, 黒瀬 心, 市橋 雅典, 遠藤 浩, 木村 泰之, 市瀬 正則, et al. 元プロボクサーにおけるタウ沈着物の分布と伝播(Distribution and propagation of tau deposits in former professional boxers). Dementia Japan. 2023. 37. 4. 654-654
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Books (10)：
  • やさしい高次脳機能障害用語事典
    ぱーそん書房 2018 ISBN:9784907095482
  • 精神科身体合併症マニュアル
    医学書院 2018 ISBN:9784260035453
  • 今日の精神疾患治療指針
    医学書院 2016 ISBN:9784260024846
  • 認知リハビリテーション実践ガイド
    医学書院 2015 ISBN:9784260021456
  • Dementia
    2012 ISBN:4521734391
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Lectures and oral presentations  (22)：
  • 反復性軽度頭部外傷による遅発性精神症状と脳内タウ病変との関連について
    (BPCNPNPPP4 2022)
  • 頭部外傷による遅発性脳障害と慢性期の脳画像所見
    (第 3 回インパクトバイオメカニクス部門委員会 2022)
  • Innovations in psychiatric disease classification using tau PET
    (2021)
  • Long-term sequelae of traumatic brain injury Clinical manifestations, neuropathology and tau PET findings
    (2021)
  • 慢性外傷性脳症(ボクサー脳症)による遅発性脳障害のタウPET/MRI所見:タウ病変と精神神経症状との関連
    (第43回日本生物学的精神医学会・第51回日本神経精神薬理学会 合同年会 2021)
ｍore...
Education (2)：
  • 2008 - 2012 Keio University PhD course
  • 1997 - 2003 Keio University School of Medicine
Professional career (2)：
  • PhD (Keio University Schools of Medicine)
  • MD (Keio University Schools of Medicine)
Work history (6)：
  • 2024/04 - 現在 National Institutes for Quantum Science and Technology (QST) Advances Neuroimaging Center, Sector for NeuroPsychiatric Disease Research Sector Leader
  • 2023/04 - 現在 Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology (QST) Department of Functional Brain Imaging
  • 2015/04 - 現在 National Institute of Radiological Sciences (NIRS) National Institutes for Quantum and Radiological Science and Technology (QST) Chiba, Japan Department of Functional Brain Imaging Research Researcher
  • 2012/04 - 2015/03 National Institute of Radiological Sciences (NIRS) National Institutes for Quantum and Radiological Science and Technology (QST) Chiba, Japan Department of Functional Brain Imaging Research PosDoc Reearcher
  • 2005/04 - 2008/03 Tachikawa Hospital Department of Psychiatry
Show all
Committee career (3)：
  • 2022/04 - 現在 Psychiatry and Clinical Neurosciences Reports Psychiatry and Clinical Neurosciences Reports Journal Editor
  • 2021/08 - 現在 Neuropsychology Association of Japan councilor
  • 2021/11 - Japan Society of Higher Brain Dysfunction a representative
Awards (4)：
  • 2023/11 - Japan Society for Dementia Research Japan Society for Dementia Research Award Distribution and propagation of tau deposits in former professional boxers
  • 2021/08 - BPNP2021 presetantion award Association of brain tau accumulation and neuropsychiatric symptoms in chronic traumatic encephalopathy: A PET study with 18F-PM-PBB3(18F-APN-1607)
  • 2017 - Japanese Society of Psychiatry and Neurology Best Oral Presentation Award Delayed-Onset Psychosis following TBI is Associated with Tau Depositions in the Neocortex but Not with β-Amyloid Depositions: A Pet Study with [11C] PBB3 and [11C]PiB
  • 2011 - Association for the Scientific Study of Consciousness Best Poster Award On saving the self: Postdictive shifts of sense of agency by monetary gain and loss
Association Membership(s) (7)：
Japan Society for Dementia Research ,  Japanese Society of Nuclear Medicine ,  The Japanse Society of Toxicology ,  THE JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY ,  Neuropsychology Association of Japan ,  JAPAN SOCIETY FOR HIGHER BRAIN DYSFUNCTION ,  The Japanese society of Psychiatry and Neurology
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