Sawada Yasuhiro

サワダヤスヒロ | Sawada Yasuhiro

Affiliation and department：
Job title：部長

Research field (4)： Cell biology , Orthopedics , Medical biochemistry , Nutrition and health science

Research keywords (4)： organismal homeostasis , exercise , mechanosensing , Mechanobiology

Research theme for competitive and other funds (10)：

2024 - 2027 力学の理解に基づく代謝異常症及び認知機能障害に対する革新的治療法開発の基盤構築
2022 - 2024 メカノバイオロジーに立脚した本態性高血圧の病因追究
2021 - 2024 メカニカルストレスが身体不活動で生じる脳・骨格筋の慢性炎症を抑制する分子機構
2020 - 2022 Deciphering the mechanism of the antihypertensive effect of physical exercise and developing its clinical application
2018 - 2021 Molecular Mechanisms of How Mechanical Stress Regulates Inflammation of Locomotive Organs

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Papers (50)：

Kei Gochi, Eriko Sumiya, Naoyoshi Sakitani, Yoshiki Otsuka, Masafumi Muratani, Shinichiro Sawa, Hiroki Ochi, Yasuhiro Sawada, Ken-ichi Nakahama, Masahiro Shinohara. A novel stromal cell source of RANKL during sustained osteoclast activation in disuse osteoporosis. The Journal of Physiology. 2026
Shuhei Murase, Naoyoshi Sakitani, Takahiro Maekawa, Daisuke Yoshino, Kouji Takano, Ayumu Konno, Hirokazu Hirai, Taku Saito, Sakae Tanaka, Keisuke Shinohara, et al. Author Correction: Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans. Nature biomedical engineering. 2023. 7. 11. 1530-1530
Shuhei Murase, Naoyoshi Sakitani, Takahiro Maekawa, Daisuke Yoshino, Kouji Takano, Ayumu Konno, Hirokazu Hirai, Taku Saito, Sakae Tanaka, Keisuke Shinohara, et al. Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans. Nature biomedical engineering. 2023
Takahiro Maekawa, Naoyoshi Sakitani, Youngjae Ryu, Atsushi Takashima, Shuhei Murase, Julius Fink, Motoshi Nagao, Toru Ogata, Masahiro Shinohara, Yasuhiro Sawada. Application of Passive Head Motion to Generate Defined Accelerations at the Heads of Rodents. Journal of Visualized Experiments. 2022. 185
Haruko Watanabe-Takano, Hiroki Ochi, Ayano Chiba, Ayaka Matsuo, Yugo Kanai, Shigetomo Fukuhara, Naoki Ito, Keisuke Sako, Takahiro Miyazaki, Kazuki Tainaka, et al. Mechanical load regulates bone growth via periosteal Osteocrin. Cell Reports. 2021. 36. 2. 109380-109380

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MISC (26)：

郷地慶, 郷地慶, 住谷瑛理子, 崎谷直義, 大塚佳輝, 村谷匡史, 澤新一郎, 越智広樹, 澤田泰宏, 中浜健一, et al. Cellular and molecular insights into the pathophysiology of disuse osteoporosis associated with physical inactivity. 日本解剖学会総会・全国学術集会抄録集(CD-ROM). 2025. 130th
郷地慶, 郷地慶, 住谷瑛理子, 崎谷直義, 大塚佳輝, 村谷匡史, 澤新一郎, 越智広樹, 澤田泰宏, 中浜健一, et al. 運動不足により生じる廃用性骨萎縮の発生過程解明とその分子基盤の確立. 日本分子生物学会年会プログラム・要旨集(Web). 2024. 47th
崎谷直義, 崎谷直義, 前川貴郊, 岸拓弥, 篠原啓介, 吉野大輔, 高野弘二, 郷地慶, 越智広樹, 篠原正浩, et al. 運動で頭部に生じる衝撃は,頭側延髄腹外側野の間質液流動の促進を介して,アストロサイトの機能を制御し,高血圧を改善する. 高血圧関連疾患モデル学会学術総会抄録集. 2023. 59th (CD-ROM)
﨑谷直義, 前川貴郊, 澤田泰宏. 力学的刺激による骨格筋恒常性維持の分子機構. 実験医学. 2022. 40. 2. 306-313
﨑谷直義, 前川貴郊, 澤田泰宏. 体表からの局所的反復性圧迫は局所のマクロファージの機能を修飾し不動化による骨格筋の萎縮を緩和する. 内分泌・糖尿病・代謝内科. 2019. 48. 6. 458-463

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