Research theme for competitive and other funds (3):
2022 - 2025 Xkr8によるリン脂質スクランブル過程の可視化
2021 - 2024 スクランブラーゼの作用機構とフリッパーゼの基質特異性の解明
2020 - 2022 The study on mechanism of phospholipid scrambling by Xkr8
Papers (7):
Takaharu Sakuragi, Ryuta Kanai, Mayumi Otani, Masahide Kikkawa, Chikashi Toyoshima, Shigekazu Nagata. The role of the C-terminal tail region as a plug to regulate XKR8 lipid scramblase. The Journal of biological chemistry. 2024. 300. 3. 105755-105755
Takaharu Sakuragi, Shigekazu Nagata. Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases. Nature Reviews Molecular Cell Biology. 2023
Takaharu Sakuragi, Ryuta Kanai, Akihisa Tsutsumi, Hirotaka Narita, Eriko Onishi, Kohei Nishino, Takuya Miyazaki, Takeshi Baba, Hidetaka Kosako, Atsushi Nakagawa, et al. The tertiary structure of the human Xkr8-Basigin complex that scrambles phospholipids at plasma membranes. Nature structural & molecular biology. 2021. 28. 10. 825-834
Takaharu Sakuragi, Ryuta Kanai, Akihisa Tsutsumi, Hirotaka Narita, Eriko Onishi, Takuya Miyazaki, Takeshi Baba, Atsushi Nakagawa, Masahide Kikkawa, Chikashi Toyoshima, et al. An intramolecular scrambling path controlled by a gatekeeper in Xkr8 phospholipid scramblase. bioRxiv. 2021
Experimental Medicine Vol.40 No.4
2022 ISBN:9784758125536
Lectures and oral presentations (2):
Structural analysis of the Xkr8-Basigin complex, a plasma membrane phospholipid scramblase
(2022)
Structural analysis of the XKR8-Basigin complex that scrambles phospholipids at the plasma membrane
(The 29th Federation of Asian and Oceanian Biochemists and Molecular Biologists Conference & the 2022 Chinese Society of Biochemistry and Molecular Biology Online Conference 2022)
Education (2):
2015 - 2019 大阪大学大学院 医学系研究科 博士課程
2007 - 2013 Kyoto University Faculty of Medicine Department of Medical Science
Professional career (1):
Doctor of Medical Science (Ph.D.) (Osaka University)
Work history (3):
2021/04 - 現在 Osaka University WPI Immunology Frontier Research Center
2019/04 - 2021/03 Osaka University WPI Immunology Frontier Research Center