Rchr
J-GLOBAL ID：201901005583485233
Update date: Oct. 31, 2024
Yuki Makino
マキノ ユウキ | Yuki Makino
Affiliation and department：
Research field (1)：
Gastroenterology
Research theme for competitive and other funds (4)：
- 2021 - 2022 肝発癌および肝癌微小環境におけるLIFの生物学的意義の解析
- 2019 - 2021 Investigation of the mechanisms of accelerated liver carcinogenesis caused by p53 over-activation.
- 2017 - 2019 Elucidation of the significance of CTGF in liver cancer for the development of novel therapy
- 2014 - 2016 Significance of connective tissue growth factor (CTGF) and tumor-stroma interaction in Kras-driven hepatocarcinogenesis and HCC progression
Papers (67)：
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Yuki Makino, Hayato Hikita, Seiya Kato, Masaya Sugiyama, Minoru Shigekawa, Tatsuya Sakamoto, Yoichi Sasaki, Kazuhiro Murai, Sadatsugu Sakane, Takahiro Kodama, et al. STAT3 is Activated by CTGF-mediated Tumor-stroma Cross Talk to Promote HCC Progression. Cellular and molecular gastroenterology and hepatology. 2022. 15. 1. 99-119
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Yuki Makino, Hayato Hikita, Kenji Fukumoto, Ji Hyun Sung, Yoshihiro Sakano, Kazuhiro Murai, Sadatsugu Sakane, Takahiro Kodama, Ryotaro Sakamori, Jumpei Kondo, et al. Constitutive activation of the tumor suppressor p53 in hepatocytes paradoxically promotes non-cell autonomous liver carcinogenesis. Cancer research. 2022. 82. 16. 2860-2873
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Kazuhiro Murai, Takahiro Kodama, Hayato Hikita, Akiyoshi Shimoda, Makoto Fukuoka, Keisuke Fukutomi, Satoshi Shigeno, Yuto Shiode, Daisuke Motooka, Yuichiro Higuchi, et al. Inhibition of nonhomologous end joining-mediated DNA repair enhances anti-HBV CRISPR therapy. Hepatology communications. 2022. 6. 9. 2474-2487
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福岡 誠, 小玉 尚宏, 疋田 隼人, 成 志弦, 下田 彬允, 福富 啓祐, 滋野 聡, 村井 一裕, 田畑 優貴, 牧野 祐紀, et al. プール型CRISPR/CasライブラリーによるHBV関連肝癌の脆弱性に注目した新規治療標的探索. 肝臓. 2022. 63. Suppl.1. A334-A334
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佐々木 陽一, 疋田 隼人, 牧野 祐紀, 小玉 尚宏, 阪森 亮太郎, 巽 智秀, 竹原 徹郎. 肝線維化進展における非実質細胞から産生されるCTGFの役割. 肝臓. 2022. 63. Suppl.1. A352-A352
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MISC (110)：
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Jihyun Sung, Hayato Hikita, Yuki Makino, Seiya Kato, Yoichi Sasaki, Kenji Fukumoto, Kazuhiro Murai, Kunimaro Furuta, Akira Nishio, Takahiro Kodama, et al. ACTIVATION OF HEPATOCYTE p53 TRIGGERS ACUTE LIVER FAILURE WITH MULTIPLE ORGAN DYSFUNCTION. HEPATOLOGY. 2023. 78. S1959-S1960
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Kenji Fukumoto, Hayato Hikita, Yoichi Sasaki, Seiya Kato, Yuta Myojin, Sadatsugu Sakane, Kazuhiro Murai, Yuki Makino, Takahiro Kodama, Ryotaro Sakamori, et al. SUPPRESSION OF MACROPHAGE AUTOPHAGY PROGRESSES THE PATHOLOGY OF NAFLD / NASH WITH CELLULAR SENESCENCE OF LSEC. HEPATOLOGY. 2021. 74. 1089A-1089A
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Kazuhiro Murai, Takahiro Kodama, Hayato Hikita, Jihyun Sung, Akiyoshi Shimoda, Makoto Fukuoka, Satoshi Shigeno, Keisuke Fukutomi, Yuki Tahata, Yuki Makino, et al. NOVEL ANTI-HBV COMBINATION TREATMENT USING CRISPR/Cas9 TARGETING HBV GENOME AND SUPPRESSION OF NHEJ-MEDIATED DNA REPAIR. HEPATOLOGY. 2021. 74. 62A-63A
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牧野祐紀, 疋田隼人, 杉山真也, 重川稔, 小玉尚宏, 阪森亮太郎, 巽智秀, 竹原徹郎. CTGFとIL-6ファミリー分子を介した腫瘍-間質クロストークによるSTAT3活性化と肝癌の増大進展. 肝細胞研究会プログラム・抄録集. 2021. 28th
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占部真貴子, 疋田隼人, 齋藤義修, 村井一裕, 牧野祐紀, 小玉尚宏, 阪森亮太郎, 巽智秀, 竹原徹郎. 放射線肝限局照射モデルマウスを用いた肝再生能の検討. 日本消化器病学会雑誌(Web). 2021. 118
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