Rchr
J-GLOBAL ID：201901005590638053
Update date: Sep. 13, 2024
HIROSHI TATEISHI
タテイシ ヒロシ | HIROSHI TATEISHI
Affiliation and department：
Job title：
Chief
Other affiliations (1)：
Homepage URL (1)：
http://www.pharm.kumamoto-u.ac.jp/Labs/bunsigouseiHP/
Research field (2)：
Pharmaceuticals - chemistry and drug development
, Pharmaceuticals - health and biochemistry
Research keywords (9)：
創薬
, 強皮症治療薬
, 抗HIV薬(Gag)
, NASH治療薬
, 糖尿病治療薬(AMPK)
, 加齢臭消臭剤(2-NEクエンチ剤)
, HPH-15
, Pro-IP6
, L-HIPPO
Research theme for competitive and other funds (10)：
- 2024 - 2027 HIV-1可視化技術によるHIV-1放出関連宿主細胞タンパク質の解明と薬剤開発
- 2024 - 2026 時計遺伝子BMAL1を標的としたNASH治療薬の開発研究
- 2022 - 2025 Development of therapeutic drugs that tandemly suppress infection, lung fibrosis, and malignant transformation of the new coronavirus
- 2023 - 2025 NASH治療薬に関する研究
- 2020 - 2023 Structure optimization of compounds to confine HIV in a cell and induce apoptosis aiming at drugs
- 2023 - 多発性嚢胞腎治療薬の開発研究
- 2020 - 2021 加齢臭原因物質を消去する化合物の開発
- 2019 - 2021 Development of the novel HIV eradication method
- 2019 - 2021 HIV-1 Gagタンパク質を標的とした薬剤スクリーニングシステム構築
- 2017 - 2019 Development of anti-HIV drug to induce apoptosis by accumulation of viral protein
Show all
Papers (55)：
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Tsugumasa Toma, Nobukazu Miyakawa, Yuiichi Arakaki, Takuro Watanabe, Ryosei Nakahara, Taha F S Ali, Tanima Biswas, Mikio Todaka, Tatsuya Kondo, Mikako Fujita, et al. An antifibrotic compound that ameliorates hyperglycaemia and fat accumulation in cell and HFD mouse models. Diabetologia. 2024
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Perpetual Nyame, Akihiro Togami, Tomofumi Yoshida, Takuya Masunaga, Mst Monira Begum, Hiromi Terasawa, Nami Monde, Yurika Tahara, Reiko Tanaka, Yuetsu Tanaka, et al. A heterocyclic compound inhibits viral release by inducing cell surface BST2/Tetherin/CD317/HM1.24. The Journal of biological chemistry. 2024. 107701-107701
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Mostafa M Badran, Samar H Abbas, Hiroshi Tateishi, Yuki Maemoto, Tsugumasa Toma, Akihiro Ito, Mikako Fujita, Masami Otsuka, Mohamed Abdel-Aziz, Mohamed O Radwan. Ligand-based design and synthesis of new trityl histamine and trityl cysteamine derivatives as SIRT2 inhibitors for cancer therapy. European journal of medicinal chemistry. 2024. 269. 116302-116302
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Teruya Nakamura, Chiaki Ohyama, Madoka Sakamoto, Tsugumasa Toma, Hiroshi Tateishi, Mihoko Matsuo, Mami Chirifu, Shinji Ikemizu, Hiroshi Morioka, Mikako Fujita, et al. TIFAB regulates the TIFA-TRAF6 signaling pathway involved in innate immunity by forming a heterodimer complex with TIFA. Proceedings of the National Academy of Sciences. 2024
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Tsugumasa Toma, Nobukazu Miyakawa, Mika Tateishi, Mikio Todaka, Tatsuya Kondo, Mikako Fujita, Masami Otsuka, Eiichi Araki, Hiroshi Tateishi. An ADAM17 selective inhibitor promotes glucose uptake by activating AMPK. Journal of Pharmacological Sciences. 2024
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MISC (4)：
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牧野雄成, 當眞嗣雅, 立石大, 藤田美歌子, 大塚雅巳, 大塚雅巳, 片岡良友. Molecular pathology of systemic sclerosis and molecular design of a therapeutic drug. Bio Clinica. 2022. 37. 9
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知念拓磨, 立石大, 島垣和功, 福田亮太, 坂本亜里紗, 坂本亜里紗, 三隅将吾, 大塚雅巳, 大塚雅巳, 藤田美歌子, et al. HIV-1Gag MAドメインとカルジオリピン誘導体との結合解析. 日本薬学会九州支部大会講演要旨集. 2021. 38th (CD-ROM)
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KAWAKAMI Kensaku, TOMA Tsugumasa, OTSUKA Masami, FUJITA Mikako, TATEISHI Hiroshi, NAKANISHI Yoshitaka, NAKASHIMA Yuta. Fabrication of co-culture device for reproducing cancer metastasis behavior in vitro. The Proceedings of Conference of Kyushu Branch. 2021. 2021.74. C33
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當眞嗣雅, 立石大, BISWAS Tanima, 加茂真宏, 藤田美歌子, 大塚雅巳, 大塚雅巳. Development of cancer matastasis inhibitors targeting at EMT. 日本薬学会年会要旨集(CD-ROM). 2020. 140th
Patents (4)：
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線維化が生じる疾患の治療用医薬用組成物
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高リン血症治療用医薬用組成物
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生活習慣病の予防又は治療に使用するための医薬組成物
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フィチン酸エステル誘導体
Lectures and oral presentations (53)：
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HIV-1の複製後期過程を標的とした薬剤のスクリーニングと機能評価
(2023)
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Development of middle molecule drug based on phytic acid (IP6)
(2023)
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Development of an anti-diabetes drug candidate that suppresses lipid accumulation
(2023)
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創薬を指向したHIV-1 Gag MAドメインとカルジオリピンとの結合解析
(日本薬学会143回年会 2023)
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Functional analysis of novel inhibitor for downstream targeting of TGF-β signaling to suppress EMT
(2023)
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Education (3)：
- 2015 - 2019 Kumamoto University Graduate School of Pharmaceutical Sciences
- 2013 - 2015 Kumamoto University Graduate School of Pharmaceutical Sciences
- 2009 - 2013 Kumamoto university
Professional career (1)：
Work history (5)：
- 2023/10 - 現在 Hirata Corporation Research & Development Chief
- 2023/10 - 現在 熊本大学, 大学院生命科学研究部(薬学系), 客員准教授
- 2019/04 - 2023/09 Kumamoto University Faculty of Life Sciences
- 2017/04 - 2019/03 日本学術振興会 特別研究員(DC2)
- 2017/02 - 薬剤師免許取得
Awards (2)：
- 2019/03 - 薬学教育部長賞 熊本大学
- 2012/03 - 日本薬学会 132年会 優秀発表賞 抗エイズ活性をもつイノシトールリン脂質誘導体の合成
Association Membership(s) (3)：
日本ケミカルバイオロジー学会
, 日本薬学会 医薬部会
, THE PHARMACEUTICAL SOCIETY OF JAPAN
