Rchr
J-GLOBAL ID：201901005628545046   Update date: Apr. 13, 2024

Saotome Tomonori

サオトメ トモノリ | Saotome Tomonori
Affiliation and department：
National Institute of Technology, Oyama College Department of Materials Chemistry and Bioengineering

About National Institute of Technology, Oyama College Department of Materials Chemistry and Bioengineering


Job title： Assistant Professor
Research field  (2)： Biophysics ,  Biophysics
Research keywords  (9)： アミロイド線維 ,  PSD95-PDZ3 ,  Differential Scanning Calorimetry ,  cooperative thermal denaturation ,  small globular proteins ,  Reversible Oligomerization (RO) at high temperature ,  Dengue Virus Envelope Protein Domain 3 ,  The thermodynamic analysis of protein folding ,  Protein science
Research theme for competitive and other funds  (2)：
  • 2023 - 2024 食品添加物リゾチームの熱凝集抑制に向けた高温でのRO形成の物性解析
  • 2021 - 2024 The development of molecular design to inhibit the amyloid fibrillation by inhibiting the reversible oligomerization at high temperature with a single residue mutation
Papers (12)：
  • Thao Tu, Tharangani Rathnayaka, Toshiyo Kato, Kenji Mizutani, Tomonori Saotome, Keiichi Noguchi, Shun-ichi Kidokoro, Yutaka Kuroda. Design and Escherichia coli Expression of a Natively Folded Multi-Disulfide Bonded Influenza H1N1-PR8 Receptor-Binding Domain (RBD). International Journal of Molecular Sciences. 2024. 25. 7. 3943-3943
  • Tomonori Saotome. The Reversible Oligomerization (RO) of Small Globular Proteins at High-Temperature and the Inhibition of Their Amyloidogenesis. Netsusokutei. 2023. 50. 3. 103-109
  • Jannatul Aklima, Sawaros Onchaiya, Tomonori Saotome, Punitha Velmurugan, Taihei Motoichi, Jannatul Naima, Yutaka Kuroda, Yoshihiro Ohta. Direct Analysis of Mitochondrial Damage Caused by Misfolded/Destabilized Proteins. International Journal of Molecular Sciences. 2022. 23. 17. 9881-9881
  • Tomonori Saotome, Sawaros Onchaiya, Brindha Subbaian, Taichi Mezaki, Satoru Unzai, Keiichi Noguchi, Jose C. Martinez, Shun-ichi Kidokoro, Yutaka Kuroda. Blocking PSD95-PDZ3's amyloidogenesis through point mutations that inhibit high-temperature reversible oligomerization (RO). The FEBS Journal. 2022. 289. 11. 3205-3216
  • Sawaros Onchaiya, Tomonori Saotome, Kenji Mizutani, Jose C Martinez, Jeremy R H Tame, Shun-Ichi Kidokoro, Yutaka Kuroda. Reverse Engineering Analysis of the High-Temperature Reversible Oligomerization and Amyloidogenicity of PSD95-PDZ3. Molecules (Basel, Switzerland). 2022. 27. 9
ｍore...
Lectures and oral presentations  (17)：
  • Physicochemical characterization of irreversible oligomers considered precursors of thermal aggregation of hen egg white lysozyme
    (第61回日本生物物理学会年会 2023)
  • The reversible oligomerization (RO) of small globular proteins at high-temperature and the artificial suppression of their amyloidogenesis
    (26th International Conference on Chemical Thermodynamics (ICCT-2023) 2023)
  • The characterization of reversible oligomer (RO) at high temperature and the assessment of thermal aggregation of hen egg white lysozyme
    (第23回 日本蛋白質科学会年会 2023)
  • Reversible Oligomerization (RO) at high temperature: a trigger of complicated thermal transition of small globular proteins
    (第12回 日本生物物理学会 関東支部会 2023)
  • The quantitative evaluation of kinetic effect on PSD95-PDZ3’s reversible oligomerization at high temperature.
    (2022)
ｍore...
Education (5)：
  • 2016 - 2019 Tokyo University of Agriculture and Technology Graduate School of Engineering, PhD Life Science and Biotechnology
  • 2018 - 2018 フランス・モンペリエ工科大学 構造生物学研究センター
  • 2015 - 2016 Tokyo University of Agriculture and Technology Graduate school of engineering, MS Biotechnology and Life Sciences
  • 2016 - 2016 フランス・モンペリエ工科大学 構造生物学研究センター
  • 2011 - 2015 Tokyo University of Agriculture and Technology Faculty of Engineering Department of Biotechnology and Life Science
Professional career (1)：
  • Doctor of Engineering (Tokyo University of Agriculture and Technology)
Work history (4)：
  • 2024/04 - 現在 National Institute of Technology, Oyama College Department of Materials Chemistry and Bioengineering Assistant Professor
  • 2022/04 - 2024/03 Nagaoka University of Technology Department of Materials Science and Bioengineering
  • 2020/12 - 2022/03 Nagaoka University of Technology Department of Bioengineering Assistant professor
  • 2019/10 - 2020/11 Tokyo University of Agriculture and Technology Institute of Global Innovation Research Project assistant professor
Association Membership(s) (3)：
日本熱測定学会 ,  日本生物物理学会 ,  日本蛋白質科学会
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