Nishimura Yoshio

ニシムラヨシオ | Nishimura Yoshio

Affiliation and department：

Research field (3)： Bioorganic chemistry , Structural/physical organic chemistry , Pharmaceuticals - chemistry and drug development

Research keywords (3)： Heterocyclic Chemistry , Medicinal Chemistry , Organic Chemistry

Research theme for competitive and other funds (9)：

2023 - 2024 遷移金属触媒合成による 2,4,4,5,6-五置換ジヒドロピリミジンのライブラリー構築
2022 - 2023 創薬資源ライブラリーの構築を指向したジヒドロピリミジンの触媒的合成
2016 - 2019 医薬応用に向けたジヒドロピリミジン誘導体のレチノイドとしての機能開発
2014 - 2016 生体内酸化現象解析を指向した活性酸素検出ジヒドロピリミジン蛍光プローブの開発
2014 - 2015 ジヒドロピリミジン誘導体を利用する活性酸素検出蛍光プローブの創製

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Papers (30)：

Yoshio Nishimura, Takanori Kubo, Nanami Shibuya, Hidetsura Cho. Fully Substituted Dihydropyrimidines, Pentasubstituted 2-Aryldihydropyrimidines Synthesized by Palladium-Catalyzed/Copper-Mediated Cross-Coupling Reaction. Synthesis. 2023. 55. 13. 1996-2004
Yoshio Nishimura, Takanori Kubo, Saho Takayama, Hanako Yoshida, Hidetsura Cho. Palladium-catalyzed/copper-mediated carbon-carbon cross-coupling reaction for synthesis of 6-unsubstituted 2-aryldihydropyrimidines. RSC Advances. 2022. 12. 43. 28113-28122
Yoshio Nishimura, Hidetomo Kikuchi, Takanori Kubo, Rie Arai, Yuki Toguchi, Bo Yuan, Katsuyoshi Sunaga, Hidetsura Cho. Synthesis of 4,4-Disubstituted 3,4-Dihydropyrimidin-2(1H)-ones and -thiones, the Corresponding Products of Biginelli Reaction Using Ketone, and Their Antiproliferative Effect on HL-60 Cells. Chemical and Pharmaceutical Bulletin. 2022. 70. 2. 111-119
Yoshio Nishimura. [Development of Efficient Synthetic Method for Tautomeric Dihydropyrimidines and Analysis of Their Functionality]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2021. 141. 2. 151-161
Yoshio Nishimura, Hidetomo Kikuchi, Takanori Kubo, Ibuki Nakakita, Mari Oguni, Misaki Ohta, Rie Arai, Bo Yuan, Katsuyoshi Sunaga, Hidetsura Cho. Synthesis of novel 6-unsubstituted 2-aminodihydropyrimidines by Sc(OTf)3-mediated amination and their antiproliferative effect on HL-60 cells. Tetrahedron Letters. 2021. 65. 152760

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Lectures and oral presentations (88)：

膵臓がん肝転移マウスモデルに対するLipid-siRNAの抗腫瘍効果
(日本薬学会第143回年会(札幌) 2023)
ヒト白血病細胞株NB4に対する2-thioxo-dihydropyrimidine誘導体#3に惹起される細胞毒性におけるMAP kinaseの関与
(日本薬学会第143回年会(札幌) 2023)
ヒト白血病NB4細胞に対するATRAと2-methylthio dihydropyrimidineの併用における分化誘導作用の検討
(日本薬学会第143回年会(札幌) 2023)
Pd 触媒/Cu 試薬を用いる Liebeskind-Srogl 型クロスカップリングによる 5 置換2-アリールジヒドロピリミジンの合成
(日本薬学会第143回年会(札幌) 2023)
Pd 触媒/Cu 試薬を用いる 5 置換 2-アリールジヒドロピリミジンの合成
(第61回日本薬学会東北支部大会(福島) 2022)

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Education (3)：

2004 - 2006 Tohoku University Graduate School of Pharmaceutical Sciences Department of Pharmaceutical Chemistry
2002 - 2004 Tohoku University Graduate School of Pharmaceutical Sciences Department of Pharmaceutical Chemistry
1998 - 2002 東北大学薬学部薬学科

Professional career (1)：

博士(薬学) (東北大学)

Work history (6)：

2021/04 - 現在 Ohu University The School of Pharmaceutical Science
2015/04 - 2021/03 Yasuda Women's University Faculty of Pharmacy Department of Pharmacy
2011/04 - 2015/03 Yasuda Women's University Faculty of Pharmacy
2009/04 - 2011/03 Yasuda Women's University Faculty of Pharmacy
2006/04 - 2009/03 Tohoku University Graduate School of Pharmaceutical Sciences

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Committee career (1)：

2017/04 - 2018/03 日本薬学会中国四国支部幹事

Awards (1)：

2019/11 - 日本薬学会中国四国支部奨励賞

Association Membership(s) (4)：

THE JAPANESE SOCIETY FOR PROCESS CHEMISTRY , THE CHEMICAL SOCIETY OF JAPAN , THE PHARMACEUTICAL SOCIETY OF JAPAN , THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN

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