HAYASHI Ryuhei

ハヤシリュウヘイ | HAYASHI Ryuhei

Affiliation and department：
Homepage URL (1)： http://www.stemed.med.osaka-u.ac.jp/index-e.html

Research field (3)： Cell biology , Medical biochemistry , Ophthalmology

Research keywords (5)： Eye/Cornea , Regenerative medicine , Epithelial Stem Cells , Organoid , Pluripotent stem cells

Research theme for competitive and other funds (9)：

2022 - 2025 Naive型多能性幹細胞の多分化能修復による分化指向性と眼関連細胞発生機序の解明
2020 - 2023 Elucidation of the mechanism of whole eye development and its reproduction in vitro by regulating scaffold environment using pluripotent stem cells
2019 - 2022 Mechanism of tissue interaction in human eye development.
2017 - 2020 Elucidation of the mechanism of corneal epithelial development using SEAM as human eye development model
2013 - 2018 Elucidation of the pathophysiology and therapeutic development of mechano-stress associated eye diseases such as glaucoma using iPS cells

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Papers (69)：

Laura Howard, Yuki Ishikawa, Tomohiko Katayama, Sung-Joon Park, Matthew J. Hill, Derek J. Blake, Kohji Nishida, Ryuhei Hayashi, Andrew J. Quantock. Single-cell transcriptomics reveals the molecular basis of human iPS cell differentiation into ectodermal ocular lineages. Communications Biology. 2024
Takeshi Soma, Yoshinori Oie, Hiroshi Takayanagi, Shoko Matsubara, Tomomi Yamada, Masaki Nomura, Yu Yoshinaga, Kazuichi Maruyama, Atsushi Watanabe, Kayo Takashima, et al. Induced pluripotent stem-cell-derived corneal epithelium for transplant surgery: a single-arm, open-label, first-in-human interventional study in Japan. The Lancet. 2024
Hiroshi Takayanagi, Ryuhei Hayashi. Status and prospects for the development of regenerative therapies for corneal and ocular diseases. Regenerative therapy. 2024. 26. 819-825
丸山和一, 白木暢彦, 浅尾和伸, 橋田徳康, 片山朋彦, 林竜平, 前田直之, 西田幸二, 村川泰裕, 小口綾貴子, et al. 炎症・感染とこれからの眼科診療眼内免疫システムの発達と免疫疾患発症における常在細菌との相互関係解明への挑戦. 日本眼科学会雑誌. 2024. 128. 3. 256-281
Masahiro Kitao, Ryuhei Hayashi, Kimihito Nomi, Reiko Kobayashi, Tomohiko Katayama, Hiroshi Takayanagi, Akiko Oguchi, Yasuhiro Murakawa, Kohji Nishida. Identification of BST2 as a conjunctival epithelial stem/progenitor cell marker. iScience. 2023. 26. 7. 107016-107016

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MISC (29)：

今泉務, 今泉務, 林竜平, 林竜平, 工藤裕司, 工藤裕司, 李小琴, 李小琴, 柴田峻, 柴田峻, et al. 脂肪組織由来間葉系幹細胞の分泌因子によるドライアイ治療薬開発に向けた基礎的検討. 日本再生医療学会総会(Web). 2022. 21st
今泉務, 林竜平, 工藤裕司, 今泉務, 林竜平, 工藤裕司, 李小琴, 柴田峻, 柴田峻, 大久保徹, et al. 間葉系幹細胞由来分泌因子よるドライアイ治療薬開発に向けた基礎的検討. 日本眼薬理学会プログラム・講演抄録集. 2021. 41st
片山朋彦, 林竜平, 大久保徹, 大久保徹, 柴田峻, 柴田峻, 高柳泰, 安川裕子, 山手百合香, 小林由紀, et al. ヒトES,iPS細胞からの角膜上皮細胞の誘導. 日本再生医療学会総会(Web). 2020. 19th
柴田峻, 柴田峻, 林竜平, 工藤裕司, 工藤裕司, 大久保徹, 大久保徹, 今泉務, 今泉務, 片山朋彦, et al. Cell-type-specific adhesion to laminin isoforms and cell competition enable purification of iPS cell-derived corneal epithelium. 日本結合組織学会学術大会抄録集. 2020. 52nd
柴田峻, 柴田峻, 林竜平, 工藤裕司, 工藤裕司, 大久保徹, 大久保徹, 片山朋彦, 石川幸, 小林由紀, et al. iPS角膜上皮シート作製工程の効率化検討-FACSを用いない角膜上皮細胞単離法の開発-. 日本再生医療学会総会(Web). 2019. 18th

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Professional career (1)：

Ph.D (Tohoku University)

Association Membership(s) (6)：

日本眼薬理学会 , ARVO , JAPANESE OPHTHALMOLOGICAL SOCIETY , JAPAN CORNEA SOCIETY , International Society for Stem Cell Research , THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE

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