Research theme for competitive and other funds (4)：
2023 - 2026 Analysis of immune responses induced by Glyco-Nanoadjuvants as vaccine platform
2021 - 2023 がん細胞の免疫原性を標的とした微粒子免疫療法の研究開発
2019 - 2023 Molecular analysis of mirror-arabinan present in cell wall polysaccharides of Mycobacteria and its degrading enzymes
2017 - 2020 Development of cancer vaccine using sugar chain and toll-like receptor agonist immobilized gold nanoparticles
Papers (13)：
Koki Murata, Kai Harayama, Mayuko Shimoda, Mayumi Niimura, Masahiro Wakao, Yasuo Suda, Toshiro Moroishi, Hiroyuki Shinchi. Improvement of the Nuclease Resistance and Immunostimulatory Activity of CpG Oligodeoxynucleotides by Conjugation to Sugar-Immobilized Gold Nanoparticles. Bioconjugate Chemistry. 2024. 35. 6. 804-815
Hiroyuki Shinchi, Masahiro Wakao, Yasuo Suda. Sugar chain based drug delivery system for targeting C-type lectin receptors on antigen presenting cells. 95(5): 645-649 (2023). 2023. 95. 5. 645-649
Seigo Tateo, Hiroyuki Shinchi, Hikaru Matsumoto, Nonoka Nagata, Masahito Hashimoto, Masahiro Wakao, Yasuo Suda. Optimized immobilization of single chain variable fragment antibody onto non-toxic fluorescent nanoparticles for efficient preparation of a bioprobe. Colloids and Surfaces B: Biointerfaces. 2023. 224. 113192
Hiroyuki Shinchi, Fumikazu Komaki, Masaharu Yuki, Haruka Ohara, Naohiro Hayakawa, Masahiro Wakao, Howard B. Cottam, Tomoko Hayashi, Dennis A. Carson, Toshiro Moroishi, et al. Glyco-Nanoadjuvants: Impact of Linker Length for Conjugating a Synthetic Small-Molecule TLR7 Ligand to Glyco-Nanoparticles on Immunostimulatory Effects. ACS Chemical Biology. 2022. 17. 4. 957-968
Hiroyuki Shinchi, Masaharu Yuki, Takayoshi Yamauchi, Mayumi Niimura, Masahiro Wakao, Howard B. Cottam, Tomoko Hayashi, Dennis A. Carson, Toshiro Moroishi, Yasuo Suda. Glyco-Nanoadjuvants: Sugar Structures on Carriers of a Small Molecule TLR7 Ligand Affect Their Immunostimulatory Activities. ACS Applied Bio Materials. 2021. 4. 3. 2732-2741
