Rchr
J-GLOBAL ID:201901006870958807
Update date: Jan. 30, 2024
Yokoyama Hideshi
Yokoyama Hideshi
Affiliation and department:
Job title:
Associate Professor
Homepage URL (1):
http://www.rs.tus.ac.jp/yokoyama/index.html
Research field (1):
Structural biochemistry
Research keywords (1):
Protein structural biology, X-ray crystallography
Research theme for competitive and other funds (8):
- 2022 - 2025 Elucidation of mechanism of inhibition by kinesin motor with structural and thermodynamic analyses and development of anticancer drugs
- 2019 - 2022 Clarification of the molecular mechanism and establishment of the basis for drug development toward epithelial cancer barrier
- 2017 - 2020 Elucidation of inhibition mechanism of kinesin motor to develop anti-cancer drugs
- 2014 - 2017 Structure determination of oligomeric membrane protein involved in forming membrane vesicles and elucidation of the regulation mechanism
- 2012 - 2015 SBDD targeting metalloenzyme RNA polymeraze of influenza virus
- 2010 - 2012 Basic research for development of novel switch part on conformation and delivery of nucleic acid
- 2009 - 2011 Synthesis and analysis of telomere quadruplex DNA-binding porphyrins based on an electrostatic interaction model
- 2009 - 2010 Three-dimensional structure of lipid-raft localized membrane protein and elucidation of the mechanism forming membrane vesicles
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Papers (48):
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Horizumi, Y., Goto, S., Takatsuka, M. & Yokoyama, H. Effects of local anesthetics on liposomal membranes determined by their inhibitory activity of lipid peroxidation. MOLECULAR PHARMACEUTICS. 2023. 20. 6. 2911-2918
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Yokoyama, H. & Matsui, I. Higher-order structure formation using refined monomer structures of lipid raft markers, Stomatin, Prohibitin, Flotillin, and HflK/C-related proteins. FEBS Open Bio. 2023. 13. 5. 926-937
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Tsunoda, C., Goto, S., Hiroshige, R., Kasai, T., Okumura, Y. & Yokoyama, H. Optimization of the stability constants of the ternary system of diclofenac/famotidine/β-cyclodextrin by nonlinear least-squares method using theoretical equations. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2023. 638. 122913
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Shibuya, A., Suzuki, A., Ogo, N., Sawada, J., Asai, A. & Yokoyama, H. Crystal structure of the motor domain of centromere-associated protein E in complex with a non-hydrolysable ATP analogue. FEBS LETTERS. 2023. 597. 8. 1138-1148
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Kurosawa, Y., Goto, S., Mitsuya, K., Otsuka, Y. & Yokoyama, H. Interaction mode of hydroxypropyl-β-cyclodextrin with vaccine adjuvant components Tween 80 and Triton X-100 revealed by fluorescence increasing-quenching analysi. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 2023. 25. 8. 6203-6213
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MISC (26):
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渋谷明日香、鈴木翠、横山英志. キネシンCENP-EとATPアナログの複合体のX線結晶構造解析. Photon Factory Activity Report 2021. 2022. 39. B. 141-141
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Shibuya, A., Ogo, N., Sawada, J., Asai, A., Yokoyama, H. Structure determination of the motor domain of centromere-associated protein E. Acta Crystallographica A-Foundation and Advances. 2021. 77. C. 709-709
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渋谷明日香、横山英志. キネシンCENP-Eの構造解析とその機能の解明. Photon Factory Activity Report 2020. 2021. 38. B. 192-192
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渋谷明日香、横山英志. キネシンCENP-Eを用いた結晶化とX線回折データの分解能の改善. Photon Factory Activity Report 2019. 2020. 37. B. 56-56
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Yokoyama, H. Structure determinations of kinesin spindle protein Eg5 in complex with its inhibitors. Photon Factory Activity Report 2018. 2019. 36. B. 126-126
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Books (7):
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理大 科学フォーラム 「編集後記」
東京理科大学 2020
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理大 科学フォーラム 「つれづれぐさ 時間の使い方」
東京理科大学 2018
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FD通信 2018.6Vol.54「薬学部生命創薬科学科「薬品物理化学2」における授業収録配信システム利用例」
東京理科大学 教育開発センター / FD啓発・広報小委員会 2018
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理工系の基礎 薬学
丸善出版 2018
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Conscience 2018.3. Vol.119 「クイズで学ぶScience(先生方の研究をクイズ形式で紹介!!)」
学校法人東京理科大学 広報課 2018
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Lectures and oral presentations (97):
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Crystallization of podocin, associated with nephrotic syndrome
(26th Congress and General Assembly of the International Union of Crystallography 2023)
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ネフローゼ症候群原因タンパク質podocinの結晶化
(日本薬学会 第143年会 2023)
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キネシンCENP-Eモータードメインと阻害剤複合体の調製と結晶化
(日本薬学会 第143年会 2023)
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The combination of polymorphsim and hydrotropes additively contributes to dissolution of indomethacin
(4th International Symposium on BA/BE of Oral Drug Products 2022)
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Effect of hydrophobic hydration on the intermolecular interaction between acidic and bacic drugs: Diffusion coefficient of Fick's law determined by diffusion ordered spectroscopy and electrochemical impedance spectroscopy.
(4th International Symposium on BA/BE of Oral Drug Products, 2022 2022)
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Education (2):
- - 2002 The University of Tokyo Graduate School of Pharmaceutical Sciences
- - 1997 The University of Tokyo Faculty of Pharmaceutical Sciences
Committee career (1):
- 2018/04 - 2020/03 日本薬学会 物理系薬学部会 関東ブロック世話人
Awards (1):
- 2009/07/11 - 膜タンパク質ストマチンの三次元構造
Association Membership(s) (1):
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