Oka Yasuyoshi

Affiliation and department：

Research field (6)： Molecular biology , Pathobiochemistry , Genomics , Genetics , Environmental effects of chemicals , Environmental effects of radiation

Research keywords (9)：ゲノムの安定性維持機構 , DNA修復 , DNA損傷応答 , アルデヒド代謝 , ゲノム解析 , プロテオーム解析 , 疾患モデル動物 , 環境変異原 , 遺伝性疾患

Research theme for competitive and other funds (11)：

2021 - 2024 アルデヒド代謝異常により発症するAMeD症候群の分子病態解明
2019 - 2022 Development of new technology to evaluate the transcription-coupling repair factors.
2021 - 2022 東アジア人集団特異的な一塩基多型の生体影響に関する研究
2021 - 2022 ホルムアルデヒド代謝異常により発症する遺伝性疾患の分子病態解明
2018 - 2021 Elucidation of the molecular pathogenesis of genetic disorders caused by defects in DNA damage response using deep proteomic analysis

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Papers (26)：

Yasuyoshi Oka, Yuka Nakazawa, Mayuko Shimada, Tomoo Ogi. Endogenous aldehyde-induced DNA-protein crosslinks are resolved by transcription-coupled repair. Nature cell biology. 2024. 26. 5. 784-796
Seiji Watanabe, Yuri Murata, Yasuyoshi Oka, Kotaro Oiwa, Mai Horiuchi, Yohei Iguchi, Okiru Komine, Akira Sobue, Masahisa Katsuno, Tomoo Ogi, et al. Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 47. e2315347120
Michiko Itoh, Atsushi Tamura, Sayaka Kanai, Miyako Tanaka, Yohei Kanamori, Ibuki Shirakawa, Ayaka Ito, Yasuyoshi Oka, Isao Hidaka, Taro Takami, et al. Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH. The Journal of experimental medicine. 2023. 220. 11
Sho Tano, Tomomi Kotani, Masato Yoshihara, Noriyuki Nakamura, Seiko Matsuo, Takafumi Ushida, Kenji Imai, Miharu Ito, Yasuyoshi Oka, Emi Sato, et al. A case of non-immune hydrops fetalis with maternal mirror syndrome diagnosed by trio-based exome sequencing: An autopsy case report and literature review. Molecular genetics and metabolism reports. 2022. 33. 100925-100925
Kohji Kato, Fuyuki Miya, Yasuyoshi Oka, Seiji Mizuno, Shinji Saitoh. A novel missense variant in CUL3 shows altered binding ability to BTB-adaptor proteins leading to diverse phenotypes of CUL3-related disorders. Journal of human genetics. 2021. 66. 5. 491-498

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Patents (1)：

造血不全、発育遅滞、高発がん性、精神機能障害のモデル動物

Books (2)：

実験医学
羊土社 2024
放射線生物研究
放射線生物研究会 2007

Lectures and oral presentations (10)：

転写領域におけるDNA-蛋白質間架橋修復
(日本放射線影響学会第67回大会 2024)
アルデヒド由来DNA損傷とその代謝異常により発症する超希少疾患AMeD症候群の病態解明
(第21回 Top Runners in TRS(AMED iD3 キャタリストユニット主催) 2024)
DNAの傷を治す仕組みと遺伝病
(第39回公益社団法人生体制御学会学術集会(市民公開講座) 2024)
Transcription-coupled repair of aldehyde-induced DNA-protein crosslinks
(2023)
Transcription-coupled repair of aldehyde-induced DNA damage
(The 96th Annual Meeting of the Japanese Biochemical Society 2023)

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Education (3)：

2006 - 2011 Nagasaki University Graduate School of Biomedical Sciences
2003 - 2005 Nagasaki University Graduate School of Biomedical Sciences
1999 - 2003 Nagasaki University School of Pharmaceutical Sciences

Work history (5)：

2019/09 - 現在 Nagoya University Research Institute of Environmental Medicine
2019/04 - 2019/08 Nagoya University Research Institute of Environmental Medicine
2016/04 - 2019/03 Nagoya University Research Institute of Environmental Medicine
2015/05 - 2016/03 Nagoya University Research Institute of Environmental Medicine
2011/08 - 2015/04 University of Copenhagen Ubiquitin Signaling Group, Department of Disease Biology, Novo Nordisk Foundation Center for Protein Research Postdoctoral Researcher

Awards (1)：

2021 - 名古屋大学環境医学研究所若手優秀論文賞 Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome

Association Membership(s) (5)：

日本放射線影響学会 , 日本小児遺伝学会 , 日本プロテオーム学会 , 日本環境変異原ゲノム学会 , 日本分子生物学会

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