Alessandro Nasti

Affiliation and department：
Job title： Specially Appointed Associate Professor

Research field (3)： Other , Tumor diagnostics and therapeutics , Immunology

Research keywords (5)： Pancreatic ductal adenocarcinoma (PDAC) , Hepatitis , Immunotherapy , Adult stem/stromal adipose tissue-derived cells (ADSCs) , Regenerative therapy

Research theme for competitive and other funds (5)：

2022 - 2024 Advanced proton beam cancer therapy
2022 - 2023 Development of pancreatic cancer immunotherapy using bispecific antibodies
2020 - 2023 Study of liver restorative therapy for a murine nonalcoholic steatohepatitis model by the administration of immune-suppressive fractions of autologous adipose tissue-derived stromal cells
2021 - 2022 Development of pancreatic cancer immunotherapy using bispecific antibodies
2014 - 2017 Analysis of characteristics of cellular subfractions in adipose tissue-derived stromal cells for development of liver repair/regenerative therapy

Papers (23)：

Alessandro Nasti, Miki Okumura, Yumie Takeshita, Tuyen Thuy Bich Ho, Yoshio Sakai, Taka-Aki Sato, Chiaki Nomura, Hisanori Goto, Yujiro Nakano, Takeshi Urabe, et al. The declining insulinogenic index correlates with inflammation and metabolic dysregulation in non-obese individuals assessed by blood gene expression. Diabetes Research and Clinical Practice. 2024. 111090-111090
Alessandro Nasti, Masaki Miyazawa, Akihiro Seki, Tuyen Thuy Bich Ho, Riei Tsurumi, Miu Awaki, Yoshio Sakai, Shuichi Kaneko. Bioinformatics Methods for the Identification of Treatment Response Prediction Markers in Pancreatic Cancer. SoMeT. 2023. 1-11
Akihiro Seki, Yoshio Sakai, Alessandro Nasti, Norihiko Ogawa, Eishiro Mizukoshi. In Abstracts: (2425) Mesenchymal stromal cells restore the NASH by ameliorating ER stress of hepatocytes derived from hepatic stellate cells. Hepatology. 2022. 76. S1. S1-S1564
Masaaki Yano*, Alessandro Nasti*, Akihiro Seki, Kosuke Ishida, Masatoshi Yamato, Hiiro Inui, Norihiko Ogawa, Shingo Inagaki, Tuyen Thuy Bich Ho, Kazunori Kawaguchi, et al. Characterization of adipose tissue-derived stromal cells of mice with nonalcoholic fatty liver disease and their use for liver repair. Regenerative therapy. 2021. 18. 497-507
Yoshio Sakai*, Alessandro Nasti*, Yumie Takeshita, Miki Okumura, Shinji Kitajima, Masao Honda, Takashi Wada, Seiji Nakamura, Toshinari Takamura, Takuro Tamura, et al. Eight-year longitudinal study of whole blood gene expression profiles in individuals undergoing long-term medical follow-up. Scientific Reports. 2021. 11. 1. 16564-16564

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MISC (16)：

酒井佳夫, NASTI Alessandro, HO Tuyen Thuy Bich, 小川憲彦, 宮澤正樹, 関晃裕, 稲垣慎吾, 野村博樹, 久米恭, 前田宗利, et al. Elucidation of Cancer Immune Response with Proton Therapy and Development of New Radioimmunotherapy. 若狭湾エネルギー研究センター研究年報. 2022. 24
酒井佳夫, NASTI Alessandro, 小川憲彦, 宮澤正樹, HO Tuyen Thuy Bich, 関晃裕, 稲垣慎吾, 野村博樹, 久米恭, 前田宗利, et al. Elucidation of Cancer Immune Response with Proton Therapy and Development of New Radioimmunotherapy. 若狭湾エネルギー研究センター研究年報. 2021. 23
Alessandro Nasti, Yoshio Sakai, Norihiko Ogawa, Masaki Miyazawa, Shingo Inagaki, Tuyen Thuy Bich Ho, Hiroki Nomura, Akihiro Seki, Kyo Kume, Munetoshi Maeda, et al. Antitumor effect of proton beam irradiation and anti-PD-L1 antibody combination therapy in subcutaneous murine models of pancreatic cancer. European Journal of Immunology. 2021. 51 (Suppl. 1). 1-448
酒井佳夫, NASTI Alessandro, 宮澤正樹, 久米恭, 前田宗利, 金子周一, 金子周一. Elucidation of Cancer Immune Response with Proton Therapy and Development of New Radioimmunotherapy. 若狭湾エネルギー研究センター研究年報. 2020. 22
酒井佳夫, NASTI Alessandro, 宮澤正樹, 久米恭, 前田宗利, 金子周一, 金子周一. Elucidation of Cancer Immune Response with Proton Therapy and Development of New Radioimmunotherapy. 若狭湾エネルギー研究センター研究年報. 2019. 21

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Patents (4)：

Response prediction markers for chemotherapeutic agents for pancreatic cancer and biliary tract cancer, and corresponding response prediction kits
Combination of chemotherapeutic agent and anti-cancer immunity enhancers
Stem cell manufacturing method
Pharmaceutical compositions based on porous zeolites as release means of pharmacologically active molecules and relative use.

Books (4)：

BIOINFORMATIC ANALYSIS OF BLOOD GENE EXPRESSION FOR COMBINATION IMMUNOTHERAPY EVALUATION IN MURINE MODEL OF PANCREATIC CANCER
World Research Library, Proceedings of ResearchWorld International Conference, Rome, Italy, 25th - 26th September 2023 2023
BIOINFORMATICS METHODS FOR THE CHARACTERIZATION OF MURINE ADIPOSE-TISSUE DERIVED STROMAL CELLS ALTERED BY CONTINUOUS ROTATION SUSPENSION
World Research Library, Proceedings of ResearchWorld International Conference, Rome, Italy, 25th - 26th September 2023 2023
Thesis/Dissertation: The CD45+ fraction in murine adipose tissue derived stromal cells harbors immune-inhibitory inflammatory cells
2018
Thesis: Chitosan-based nanoparticles and microparticles
2008

Lectures and oral presentations (50)：

BIOINFORMATIC ANALYSIS OF BLOOD GENE EXPRESSION FOR COMBINATION IMMUNOTHERAPY EVALUATION IN MURINE MODEL OF PANCREATIC CANCER
(RW- 1541st International Conference on Internet Technologies and Society (ICITS) 2023)
BIOINFORMATICS METHODS FOR THE CHARACTERIZATION OF MURINE ADIPOSE-TISSUE DERIVED STROMAL CELLS ALTERED BY CONTINUOUS ROTATION SUSPENSION
(RW- 1541st International Conference on Internet Technologies and Society (ICITS) 2023)
Bioinformatics methods for the identification of treatment response prediction markers in pancreatic cancer
(The 22nd International Conference on Intelligent Software Methodologies, Tools and Techniques 2023)
Novel diagnostic/prediction systems and combination immunotherapies for pancreatic cancer.
(2nd Symposium of the Association of Italian Researchers in Japan 2023)
Biomarkers that can predict insulin secretion ability after 8 years
(The 66th Annual Meeting of the Japan Diabetes Society 2023)

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Education (6)：

2011 - 2018 Kanazawa University Graduate School of Medical Science. Department of Graduate School of Advanced Preventive Medical Sciences (System Biology), Kanazawa, Japan PhD in Medical Sciences
2006 - 2008 The University of Manchester School of Pharmacy and Pharmaceutical Sciences. Laboratory of Polymers and Biomaterials, Manchester, UK Doctoral study exchange programme
2005 - 2008 Università degli Studi di Napoli Federico II Faculty of Pharmacy, Napoli, Italy PhD in Medicinal Chemistry
1999 - 2004 Università degli Studi di Napoli Federico II Faculty of Pharmacy, Napoli, Italy Master of Sciences of Pharmacy (MPharm)
2002 - 2003 Procter & Gamble Italian Research Center, Pescara, Italy Research Internship

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Professional career (3)：

PhD in Medical Sciences (Kanazawa University; Kanazawa, JAPAN)
PhD in Medicinal Chemistry (University of Naples Federico II; Naples, ITALY)
Master in Pharmacy (University of Naples Federico II; Naples, ITALY)

Work history (3)：

2011/10 - 現在 Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences; System Biology, Kanazawa, Japan Engaged in the research of immunotherapies for the diseases of the gastrointestinal tract: specifically for liver and intestinal diseases. Postdoctoral Researcher
2009/05 - 2011/09 Lincoln County Hospital, UK National Health Service (NHS), Lincoln, UK Provided service to wards and departments, exercised professional supervision over clinical use of drugs in patients. Rotational Clinical Pharmacist
2009/03 - 2009/04 The University of Manchester, School of Pharmacy and Pharmaceutical Sciences. Laboratory of Polymers and Biomaterials, Manchester, UK Support and supervision of PhD students. Focused on the preparation of biocompatible nanoparticles and microparticles for drug delivery. Honorary Research Associate

Awards (1)：

2021/02 - Kanazawa University Papers of the Month Project Blending the old and the new to fight pancreatic cancer

Association Membership(s) (2)：

Association of Italian Researchers in Japan (AIRJ) , THE JAPANESE SOCIETY FOR IMMUNOLOGY

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