Alessandro Nasti

Affiliation and department：
Job title： Specially Appointed Associate Professor

Research field (3)： Other , Tumor diagnostics and therapeutics , Immunology

Research keywords (6)： Blood transcriptomics , Pancreatic ductal adenocarcinoma (PDAC) , Hepatitis , Immunotherapy , Adult stem/stromal adipose tissue-derived cells (ADSCs) , Regenerative therapy

Research theme for competitive and other funds (7)：

2024 - 2029 Proton radiation therapy combined with immunotherapy for enhancing antitumor immune responses in pancreatic cancer murine models.
2024 - 2025 Advanced proton beam cancer therapy
2022 - 2024 Advanced proton beam cancer therapy
2022 - 2023 Development of pancreatic cancer immunotherapy using bispecific antibodies
2020 - 2023 Study of liver restorative therapy for a murine nonalcoholic steatohepatitis model by the administration of immune-suppressive fractions of autologous adipose tissue-derived stromal cells

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Papers (24)：

Alessandro Nasti, Miki Okumura, Yumie Takeshita, Tuyen Thuy Bich Ho, Yoshio Sakai, Taka-Aki Sato, Chiaki Nomura, Hisanori Goto, Yujiro Nakano, Takeshi Urabe, et al. The declining insulinogenic index correlates with inflammation and metabolic dysregulation in non-obese individuals assessed by blood gene expression. Diabetes Research and Clinical Practice. 2024. 111090-111090
奥村美輝, 竹下有美枝, 喜多裕樹, 野村千晶, 船崎友馨, 田中健雄, 後藤久典, 中野雄二郎, Alessandro Nasti, 酒井佳夫, et al. 8年後のインスリン分泌能を予知しうるバイオマーカー. 糖尿病. 2023. 66. Suppl.1. S-182
Alessandro Nasti, Masaki Miyazawa, Akihiro Seki, Tuyen Thuy Bich Ho, Riei Tsurumi, Miu Awaki, Yoshio Sakai, Shuichi Kaneko. Bioinformatics Methods for the Identification of Treatment Response Prediction Markers in Pancreatic Cancer. SoMeT. 2023. 1-11
Akihiro Seki, Yoshio Sakai, Alessandro Nasti, Norihiko Ogawa, Eishiro Mizukoshi. In Abstracts: (2425) Mesenchymal stromal cells restore the NASH by ameliorating ER stress of hepatocytes derived from hepatic stellate cells. Hepatology. 2022. 76. S1. S1-S1564
Masaaki Yano*, Alessandro Nasti*, Akihiro Seki, Kosuke Ishida, Masatoshi Yamato, Hiiro Inui, Norihiko Ogawa, Shingo Inagaki, Tuyen Thuy Bich Ho, Kazunori Kawaguchi, et al. Characterization of adipose tissue-derived stromal cells of mice with nonalcoholic fatty liver disease and their use for liver repair. Regenerative therapy. 2021. 18. 497-507

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MISC (18)：

Alessandro NASTI, Akihiro SEKI, Kosuke SATOMURA, Tuyen Thuy Bich HO, Yoshio SAKAI, Norihiko OGAWA, Shingo INAGAKI, Masaki MIYAZAWA, Hiroki NOMURA, Kyo KUME, et al. Elucidation of Cancer Immune Response with Proton Therapy and Development of New Radioimmunotherapy. Wakasa Wan Energy Research Centre Research Annual Report. 2024. 26. 12-13
Alessandro NASTI, Yoshio SAKAI, Norihiko OGAWA, Tuyen Thuy Bich HO, Masaki MIYAZAWA, Shingo INAGAKI, Akihiro SEKI, Taro YAMASHITA, Kosuke SATOMURA, Hiroki NOMURA, et al. Elucidation of Cancer Immune Response with Proton Therapy and Development of New Radioimmunotherapy. Annual Report of the Wakasa Wan Energy Research Center. 2023. 25. L6940A. 11-12
酒井佳夫, NASTI Alessandro, HO Tuyen Thuy Bich, 小川憲彦, 宮澤正樹, 関晃裕, 稲垣慎吾, 野村博樹, 久米恭, 前田宗利, et al. Elucidation of Cancer Immune Response with Proton Therapy and Development of New Radioimmunotherapy. 若狭湾エネルギー研究センター研究年報. 2022. 24
酒井佳夫, NASTI Alessandro, 小川憲彦, 宮澤正樹, HO Tuyen Thuy Bich, 関晃裕, 稲垣慎吾, 野村博樹, 久米恭, 前田宗利, et al. Elucidation of Cancer Immune Response with Proton Therapy and Development of New Radioimmunotherapy. 若狭湾エネルギー研究センター研究年報. 2021. 23
Alessandro Nasti, Yoshio Sakai, Norihiko Ogawa, Masaki Miyazawa, Shingo Inagaki, Tuyen Thuy Bich Ho, Hiroki Nomura, Akihiro Seki, Kyo Kume, Munetoshi Maeda, et al. Antitumor effect of proton beam irradiation and anti-PD-L1 antibody combination therapy in subcutaneous murine models of pancreatic cancer. European Journal of Immunology. 2021. 51 (Suppl. 1). 1-448

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Patents (4)：

Response prediction markers for chemotherapeutic agents for pancreatic cancer and biliary tract cancer, and corresponding response prediction kits
Combination of chemotherapeutic agent and anti-cancer immunity enhancers
Stem cell manufacturing method
Pharmaceutical compositions based on porous zeolites as release means of pharmacologically active molecules and relative use.

Books (4)：

BIOINFORMATIC ANALYSIS OF BLOOD GENE EXPRESSION FOR COMBINATION IMMUNOTHERAPY EVALUATION IN MURINE MODEL OF PANCREATIC CANCER
World Research Library, Proceedings of ResearchWorld International Conference, Rome, Italy, 25th - 26th September 2023 2023
BIOINFORMATICS METHODS FOR THE CHARACTERIZATION OF MURINE ADIPOSE-TISSUE DERIVED STROMAL CELLS ALTERED BY CONTINUOUS ROTATION SUSPENSION
World Research Library, Proceedings of ResearchWorld International Conference, Rome, Italy, 25th - 26th September 2023 2023
Thesis/Dissertation: The CD45+ fraction in murine adipose tissue derived stromal cells harbors immune-inhibitory inflammatory cells
2018
Thesis: Chitosan-based nanoparticles and microparticles
2008

Lectures and oral presentations (61)：

Combination therapy of proton beam irradiation and PD-L1 inhibitor induced an immune response in murine models of pancreatic cancer
(The 53rd Annual Meeting of the Japanese Society for Immunology (JSI2024) 2024)
Cystatin A enhances CD4+ T cells and M1 macrophages antitumor activity in murine models of pancreatic cancer
(The 53rd Annual Meeting of the Japanese Society for Immunology (JSI2024) 2024)
Cystatin A enhances CD4+ T cells and M1 macrophages antitumor activity in murine models of pancreatic cancer
(The 53rd Annual Meeting of the Japanese Society for Immunology (JSI2024) 2024)
Immune response evaluation in pancreatic cancer mouse models following proton beam irradiation and anti-PD-L1 immunotherapy
(The 47th Annual Meeting of the Molecular Biology Society of Japan (MBSJ2024) 2024)
Blood gene expression assessed in non-obese individuals confirms the link between declining insulinogenic index, inflammation and metabolic dysregulation
(The 47th Annual Meeting of the Molecular Biology Society of Japan (MBSJ2024) 2024)

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Education (6)：

2011 - 2018 Kanazawa University Graduate School of Medical Science. Department of Graduate School of Advanced Preventive Medical Sciences (System Biology), Kanazawa, Japan PhD in Medical Sciences
2006 - 2008 The University of Manchester School of Pharmacy and Pharmaceutical Sciences. Laboratory of Polymers and Biomaterials, Manchester, UK Doctoral study exchange programme
2005 - 2008 Università degli Studi di Napoli Federico II Faculty of Pharmacy, Napoli, Italy PhD in Medicinal Chemistry
1999 - 2004 Università degli Studi di Napoli Federico II Faculty of Pharmacy, Napoli, Italy Master of Sciences of Pharmacy (MPharm)
2002 - 2003 Procter & Gamble Italian Research Center, Pescara, Italy Research Internship

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Professional career (3)：

PhD in Medical Sciences (Kanazawa University; Kanazawa, JAPAN)
PhD in Medicinal Chemistry (University of Naples Federico II; Naples, ITALY)
Master in Pharmacy (University of Naples Federico II; Naples, ITALY)

Work history (3)：

2011/10 - 現在 Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences; System Biology, Kanazawa, Japan Engaged in the research of immunotherapies for the diseases of the gastrointestinal tract: specifically for liver and intestinal diseases. Postdoctoral Researcher
2009/05 - 2011/09 Lincoln County Hospital, UK National Health Service (NHS), Lincoln, UK Provided service to wards and departments, exercised professional supervision over clinical use of drugs in patients. Rotational Clinical Pharmacist
2009/03 - 2009/04 The University of Manchester, School of Pharmacy and Pharmaceutical Sciences. Laboratory of Polymers and Biomaterials, Manchester, UK Support and supervision of PhD students. Focused on the preparation of biocompatible nanoparticles and microparticles for drug delivery. Honorary Research Associate

Committee career (1)：

2024/07 - 現在 Association of Italian Researchers in Japan (AIRJ) AIRJ Board

Awards (1)：

2021/02 - Kanazawa University Papers of the Month Project Blending the old and the new to fight pancreatic cancer

Association Membership(s) (3)：

Japanese Society of Gastroenterology (JSGE) , Association of Italian Researchers in Japan (AIRJ) , THE JAPANESE SOCIETY FOR IMMUNOLOGY

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