Niwa Fumihiro

ニワフミヒロ | Niwa Fumihiro

Affiliation and department：
Job title： Assistant Professor

Research field (4)： Pharmacology , Neuroscience - general , Biophysics , Cell biology

Research keywords (9)： Neuroscience , Cell Biology , Neuropharmacology , Super resolution imaging (PALM/STORM) , single molecule imaging , Biochemistry , Biophysics , genome editing (CRISPR/Cas) , in utero electroporation

Research theme for competitive and other funds (9)：

2023 - 2025 Molecular basis of morphine analgesic tolerance by GPCR hetero-dimerisation
2018 - 2021 Inhibitory neurotransmitter release and receptor dynamics during synaptic transmission: real-time imaging at single molecule level - SynTrack (Project-ANR-17-CE13-0030)
2016 - 2017 The role of excitatory activity for the plasticity of inhibitory synapse
2016 - 2017 Regulatory mechanism of inhibitory synaptic plasticity by excitatory synaptic activity
2016 - 2017 The role of excitatory activity for the plasticity of inhibitory synapses

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Papers (13)：

Hiroko Bannai, Fumihiro Niwa, Shigeo Sakuragi, Katsuhiko Mikoshiba. Inhibitory synaptic transmission tuned by Ca2+ and glutamate through the control of GABAAR lateral diffusion dynamics. Development, Growth & Differentiation. 2020
Hiroko Bannai, Takafumi Inoue, Matsumi Hirose, Fumihiro Niwa, Katsuhiko Mikoshiba. Synaptic Function and Neuropathological Disease Revealed by Quantum Dot-Single-Particle Tracking. Neuromethods. 2020. 131-155
Fumihiro Niwa. cAMP-EPAC-dependent regulation of gephyrin phosphorylation and GABAAR trapping at inhibitory synapses. iScience. 2019. 22. 453-465
Bannai H, Hirose M, Niwa F, Mikoshiba K. Dissection of Local Ca2+ Signals in Cultured Cells by Membrane-targeted Ca2+ Indicators. Journal of visualized experiments : JoVE. 2019. 145
Shigeo Sakuragi, Fumihiro Niwa, Yoichi Oda, Katsuhiko Mikoshiba, Hiroko Bannai. Astroglial Ca2+ signaling is generated by the coordination of IP3R and store-operated Ca2+- channels. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017. 486. 4. 879-885

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MISC (3)：

Hiroko Bannai, Fumihiro Niwa, Misa Arizono, Antoine Triller. Molecular mechanism underlying the inhibitory synaptic plasticity revealed by single molecule imaging. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S33-S33
M. Arizono, H. Bannai, K. Nakamura, F. Niwa, M. Enomoto, T. Matsu-ura, A. Miyamoto, M. W. Sherwood, T. Nakamura, K. Mikoshiba. Receptor-selective diffusion barrier enhances sensitivity of astrocytic processes to metabotropic glutamate receptor stimulation. JOURNAL OF NEUROCHEMISTRY. 2012. 123. 116-116
F. Niwa, H. Bannai, M. Arizono, K. Fukatsu, A. Triller, K. Mikoshiba. Gephyrin-independent GABAAR mobility and clustering during plasticity. JOURNAL OF NEUROCHEMISTRY. 2012. 123. 59-60

Lectures and oral presentations (7)：

Single molecular localization microscopy of GABAAR
(HKUST-ENS Joint Workshop on Inhibitory Synaptic Transmission 2021)
Molecular mechanisms of the regulation of inhibitory neurotransmitter receptors
(The 43rd Annual Meeting of the Molecular Biology Society of Japan 2020)
Regulation of Inhibitory synapse by cAMP-dependent pathway in Spinal cord neurons
(Symposium tribute to Maxime DAHAN 2019)
Single particle tracking of GABAA receptor with super-resolution microscopy
(Life science seminar for student, HKUST 2018)
Homeostatic regulation of GABA synapses through the control of receptor diffusion by IP3/Ca2+ signaling
(Jacques Monod Conference - Optical imaging of brain structure and function on multiple special scales)

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Education (2)：

2007 - 2012 The University of Tokyo Graduate school of frontier sciences Department of medical sciences
2003 - 2007 The University of Tokyo Faculty of Science Department of Biology

Professional career (1)：

Ph.D (The University of Tokyo)

Work history (7)：

2022/11 - 現在 Jichi Medical University Department of medicine, Division of Molecular pharmacology Assistant professor
2022/10 - 現在 JSPS
2017/10 - 2022/10 INSERM, Institut national de la santé et de la recherche médicale INSERM U1024, IBENS, Institut de Biologie de l'Ecole Normale Superieure postdoc
2016/10 - 2017/09 Bourse Gouvernement Francais postdoc
2016/04 - 2017/03 TOYOBO Biotechnology foundation scholorship postdoc

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Association Membership(s) (4)：

The Japanese Pharmacological Society , THE JAPAN NEUROSCIENCE SOCIETY , The Japanese Society for Neurochemistry , THE BIOPHYSICAL SOCIETY OF JAPAN

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