Higuchi Takashi

ヒグチタカシ | Higuchi Takashi

Affiliation and department：
Job title：部長
Other affiliations (1)：

Kanazawa University

Research field (1)： Orthopedics

Research keywords (4)：肉腫 , 腫瘍学 , 整形外科 , 骨軟部腫瘍

Research theme for competitive and other funds (6)：

2020 - 2022 マルチキナーゼ阻害薬による新規骨肉腫治療の開発
2021 - 2022 Clinical and pathological analysis of factors affecting chemoresistance in osteosarcoma patients
2021 - 2022 Analysis of effects of multikinase inhibitors on osteosarcoma
2019 - 2019 肉腫の転移浸潤メカニズムの解明と新規治療の開発
2017 - 2018 Graduate-Level Research Exchange

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Papers (137)：

Yohei Asano, Norio Yamamoto, Satoru Demura, Katsuhiro Hayashi, Akihiko Takeuchi, Satoshi Kato, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Yuta Taniguchi, et al. Novel predictors of immune checkpoint inhibitor response and prognosis in advanced non-small-cell lung cancer with bone metastasis. Cancer medicine. 2023. 12. 11. 12425-12437
Yoshihiro Araki, Naofumi Asano, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Kensaku Abe, Yuta Taniguchi, et al. A validation study for the utility of serum microRNA as a diagnostic and prognostic marker in patients with osteosarcoma. Oncology letters. 2023. 25. 6. 222-222
Masuyo Miyake, Kentaro Miyake, Qinghong Han, Kentaro Igarashi, Kei Kawaguchi, Maryam Barangi, Tasuku Kiyuna, Norihiko Sugisawa, Takashi Higuchi, Hiromichi Oshiro, et al. Synergy of oral recombinant methioninase (rMETase) and 5-fluorouracil on poorly differentiated gastric cancer. Biochemical and biophysical research communications. 2023. 643. 48-54
Takashi Higuchi, Akihiko Takeuchi, Seiichi Munesue, Norio Yamamoto, Katsuhiro Hayashi, Ai Harashima, Yasuhiko Yamamoto, Hiroyuki Tsuchiya. A nonsteroidal anti-inflammatory drug, zaltoprofen, inhibits the growth of extraskeletal chondrosarcoma cells by inducing PPARγ, p21, p27, and p53. Cell Cycle. 2023. 22. 8. 939-950
Yoshihiro Araki, Norio Yamamoto, Takashi Higuchi, Hiroyuki Tsuchiya. A Traumatic Intermuscular Hematoma Mimicking a Soft-tissue Tumor: A Case Report and Literature Review. In Vivo. 2022. 36. 6. 3018-3022

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MISC (188)：

五十嵐健太郎, 山本憲男, 樋口貴史, ロバート・ホフマン, 土屋弘行. 【軟部肉腫の治療update】マウスモデルを用いた軟部肉腫に対する新規治療薬開発. 整形・災害外科. 2022. 65. 3. 311-319
荒木麗博, 山本憲男, 林克洋, 武内章彦, 三輪真嗣, 五十嵐健太郎, 樋口貴史, 米澤宏隆, 森永整, 淺野陽平, et al. 悪性骨腫瘍切除後の再建に使用した液体窒素処理自家骨の骨シンチによるviability評価. 日本整形外科学会雑誌. 2022. 96. 2. S293-S293
荒木麗博, 山本憲男, 前田亨, 木村浩明, 樋口貴史, 土屋弘行. 2-5cmサイズの軟部腫瘍への対応の検討. 日本癌治療学会学術集会抄録集. 2021. 59回. O82-1
荒木麗博, 山本憲男, 林克洋, 武内章彦, 三輪真嗣, 五十嵐健太郎, 樋口貴史, 米澤宏隆, 森永整, 淺野陽平, et al. 75歳以上の原発性骨肉腫8例について. 日本整形外科学会雑誌. 2021. 95. 6. S1428-S1428
荒木麗博, 山本憲男, 林克洋, 武内章彦, 三輪真嗣, 五十嵐健太郎, 樋口貴史, 米澤宏隆, 森永整, 淺野陽平, et al. 骨肉腫の生検組織内の破骨細胞数による術前補助化学療法の有効性の予測. 日本整形外科学会雑誌. 2021. 95. 3. S891-S891

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Lectures and oral presentations (79)：

Efficacy of multi-kinase inhibitors in osteosarcoma treatment: A patient-derived orthotopic xenograft study
(The 37th Annual Research Meeting of the Japanese Orthopaedic Association)
Efficacy of multi-kinase inhibitors in osteosarcoma treatment: A patient-derived orthotopic xenograft study
(21st International Society Of Limb Salvage (ISOLS) General Meeting)
PPARγ agonist overcomes doxorubicin-resistance by modulating P-glycopr otein in vitro and in vivo
Pioglitazone, an Agonist of Peroxisome Proliferator-Activated Receptor Gamma, Overcomes Doxorubicin-Resistance in an Osteosarcoma Patient-Derived Orthotopic Xenograft Nude Mouse Model by Modulating P-Glycoprotein
(2021 Annual meeting of the American Academy of Orthopaedic Surgeons (AAOS) 2021)
肉腫の転移浸潤メカニズムの解明と新規治療の開発
(令和3年度(2021)金沢大学十全医学会学術集会 2021)

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Education (2)：

- 2018 Kanazawa University Graduate School of Medical Science
- 2009 Kanazawa University

Professional career (1)：

医学博士 (金沢大学大学院医薬保健学総合研究科)

Work history (9)：

2022/04 - 現在 Kanazawa Red Cross Hospital Orthopaedic Surgery Manager
2020/04 - 2022/03 Japanese Red Cross Kanazawa Hospital Orahopaedic Surgery vice manager
2020/01 - 2020/03 Kanazawa University Hospital Department of Orthopaedic Surgery Medical staff
2017/11 - 2019/12 University of California San Diego (UCSD) Department of Surgery Visiting scholar
2013/10 - 2017/10 金沢大学付属病院整形外科医員

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Awards (4)：

2021/06 - Kanazawa University Juzen Medical Society 1st Juzen Medical Encouragement Award Mechanism of metastasis and new treatment development in sarcoma
2018/10 - 39th Société Internationale de Chirurgie Orthopédique et de Traumatologie(SICOT)Orthopaedic World Congress The Lester Lowe SICOT Award
2018/09 - Kanazawa University President Award Anti-tumor effects of a non-steroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression
2017/10 - Society Encouragement Award

Association Membership(s) (5)：

International Society Of Limb Salvage , Société Internationale de Chirurgie Orthopédique et de Traumatologie International Society of Orthopaedic Surgery and Traumatology , JAPAN SOCIETY OF CLINICAL ONCOLOGY , The Central Japan Association of Orthopaedic Surgery and Traumatology , THE JAPANESE ORTHOPAEDIC ASSOCIATION

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