Higuchi Takashi

ヒグチタカシ | Higuchi Takashi

Affiliation and department：
Job title：部長
Other affiliations (1)：

Kanazawa University

Research field (1)： Orthopedics

Research keywords (4)：肉腫 , 腫瘍学 , 整形外科 , 骨軟部腫瘍

Research theme for competitive and other funds (8)：

2024 - 2029 骨肉腫における後期糖化産物受容体(RAGE)を標的とした病態解析と新規治療の開発
2025 - 2025 後期糖化産物受容体を標的とした骨肉腫の病態解明と新しい治療法の開発
2020 - 2022 マルチキナーゼ阻害薬による新規骨肉腫治療の開発
2021 - 2022 Clinical and pathological analysis of factors affecting chemoresistance in osteosarcoma patients
2021 - 2022 Analysis of effects of multikinase inhibitors on osteosarcoma

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Papers (162)：

Sei Morinaga, Qinghong Han, Kohei Mizuta, Byung Mo Kang, Michael Bouvet, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Kentaro Igarashi, et al. Highly Synergistic Eradication of 143B Osteosarcoma Cells In Vitro by the Combination of Recombinant Methioninase, Chloroquine, and Rapamycin Targeting Methionine Addiction, Autophagy, and mTOR, Respectively. Anticancer research. 2025. 45. 3. 935-941
Sei Morinaga, Qinghong Han, Kohei Mizuta, Byung Mo Kang, Chihiro Hozumi, Michael Bouvet, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, et al. Recombinant Methioninase (rMETase) Synergistically Sensitizes Ivermectin-resistant MCF-7 Breast Cancer Cells 9.9 Fold to Low-dose Ivermectin. Anticancer research. 2025. 45. 2. 451-455
Sei Morinaga, Qinghong Han, Kohei Mizuta, Byung Mo Kang, Michael Bouvet, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Kentaro Igarashi, et al. HT1080 Fibrosarcoma With Acquired Trabectedin Resistance: Increased Malignancy But Sustained Sensitivity to Methionine Restriction. In vivo (Athens, Greece). 2025. 39. 2. 683-690
Sei Morinaga, Ming Zhao, Kohei Mizuta, Byung Mo Kang, Michael Bouvet, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Kentaro Igarashi, et al. Dynamic Fluorescence Imaging of Orally-administered Tumor-targeting Salmonella typhimurium A1-R Expressing Green Fluorescent Protein Trafficking Through the Gastrointestinal System to Target Fibrosarcomas in Nude Mice. In vivo (Athens, Greece). 2025. 39. 2. 640-647
Sei Morinaga, Qinghong Han, Kohei Mizuta, Byung Mo Kang, Michael Bouvet, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Kentaro Igarashi, et al. Elevated-c-MYC-expressing Fibrosarcoma Cells With Acquired Gemcitabine Resistance Remain Sensitive to Recombinant Methioninase: A Potential Clinical Strategy for a Recalcitrant Disease. Cancer diagnosis & prognosis. 2025. 5. 1. 8-14

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MISC (189)：

五十嵐健太郎, 山本憲男, 樋口貴史, ロバート・ホフマン, 土屋弘行. 【軟部肉腫の治療update】マウスモデルを用いた軟部肉腫に対する新規治療薬開発. 整形・災害外科. 2022. 65. 3. 311-319
荒木麗博, 山本憲男, 林克洋, 武内章彦, 三輪真嗣, 五十嵐健太郎, 樋口貴史, 米澤宏隆, 森永整, 淺野陽平, et al. 悪性骨腫瘍切除後の再建に使用した液体窒素処理自家骨の骨シンチによるviability評価. 日本整形外科学会雑誌. 2022. 96. 2. S293-S293
荒木麗博, 山本憲男, 前田亨, 木村浩明, 樋口貴史, 土屋弘行. 2-5cmサイズの軟部腫瘍への対応の検討. 日本癌治療学会学術集会抄録集. 2021. 59回. O82-1
Takashi Higuchi, Kentaro Igarashi, Hiromichi Oshiro, Kentaro Miyake, Norihiko Sugisawa, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Zhenfeng Duan, et al. Patient-derived orthotopic xenograft models for osteosarcoma individualized precision treatment and effective drug discovery. Annals of Joint. 2021. 6
荒木麗博, 山本憲男, 林克洋, 武内章彦, 三輪真嗣, 五十嵐健太郎, 樋口貴史, 米澤宏隆, 森永整, 淺野陽平, et al. 75歳以上の原発性骨肉腫8例について. 日本整形外科学会雑誌. 2021. 95. 6. S1428-S1428

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Lectures and oral presentations (93)：

ラーニングカーブ初期の術者におけるmobile-bearing UKAとfixed-bearing UKA
(第55回日本人工関節学会 2025)
Lantern Surgical AssistantによるSoft tissue respecting kinematic alignment (STR-KA) TKA
(第55回日本人工関節学会 2025)
大腿軟部腫瘤の一例
(第17回金沢骨軟部腫瘍セミナー 2024)
基幹病院勤務医におけるジクトルテープ75mgの使用経験~なぜ、整形外科医こそジクトルテープなのか~
(ジクトルテープ75mg発売3周年記念講演会in石川県 2024)
PPAR gamma agonist overcomes doxorubicin-resistance by modulating P-glycopr otein
(2024)

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Education (2)：

- 2018 Kanazawa University Graduate School of Medical Science
- 2009 Kanazawa University

Professional career (1)：

医学博士 (金沢大学大学院医薬保健学総合研究科)

Work history (9)：

2022/04 - 現在 Kanazawa Red Cross Hospital Orthopaedic Surgery Manager
2020/04 - 2022/03 Japanese Red Cross Kanazawa Hospital Orahopaedic Surgery vice manager
2020/01 - 2020/03 Kanazawa University Hospital Department of Orthopaedic Surgery Medical staff
2017/11 - 2019/12 University of California San Diego (UCSD) Department of Surgery Visiting scholar
2013/10 - 2017/10 金沢大学付属病院整形外科医員

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Awards (4)：

2021/06 - Kanazawa University Juzen Medical Society 1st Juzen Medical Encouragement Award Mechanism of metastasis and new treatment development in sarcoma
2018/10 - 39th Société Internationale de Chirurgie Orthopédique et de Traumatologie(SICOT)Orthopaedic World Congress The Lester Lowe SICOT Award
2018/09 - Kanazawa University President Award Anti-tumor effects of a non-steroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression
2017/10 - Society Encouragement Award

Association Membership(s) (5)：

International Society Of Limb Salvage , Société Internationale de Chirurgie Orthopédique et de Traumatologie International Society of Orthopaedic Surgery and Traumatology , JAPAN SOCIETY OF CLINICAL ONCOLOGY , The Central Japan Association of Orthopaedic Surgery and Traumatology , THE JAPANESE ORTHOPAEDIC ASSOCIATION

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