J-GLOBAL ID:201901007826407964   Update date: Oct. 20, 2021

Higuchi Takashi

ヒグチ タカシ | Higuchi Takashi
Affiliation and department:
Job title: 副部長
Other affiliations (1):
  • 金沢大学医薬保健学域医薬保健学総合研究科  整形外科学   協力研究員
Research field  (1): Orthopedics
Research keywords  (4): 肉腫 ,  腫瘍学 ,  整形外科 ,  骨軟部腫瘍
Research theme for competitive and other funds  (6):
  • 2020 - 2022 マルチキナーゼ阻害薬による新規骨肉腫治療の開発
  • 2021 - 2022 Clinical and pathological analysis of factors affecting chemoresistance in osteosarcoma patients
  • 2021 - 2022 Analysis of effects of multikinase inhibitors on osteosarcoma
  • 2019 - 2019 肉腫の転移浸潤メカニズムの解明と新規治療の開発
  • 2017 - 2018 Graduate-Level Research Exchange
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Papers (108):
  • Norihiko Sugisawa, Takashi Higuchi, Qinghong Han, Chihiro Hozumi, Jun Yamamoto, Yoshihiko Tashiro, Hiroto Nishino, Kei Kawaguchi, Michael Bouvet, Takuya Murata, et al. Oral recombinant methioninase combined with paclitaxel arrests recalcitrant ovarian clear cell carcinoma growth in a patient-derived orthotopic xenograft (PDOX) nude-mouse model. Cancer chemotherapy and pharmacology. 2021. 88. 1. 61-67
  • Hiromichi Oshiro, Yasunori Tome, Kentaro Miyake, Takashi Higuchi, Norihiko Sugisawa, Fuminori Kanaya, Kotaro Nishida, Robert M Hoffman. An mTOR and VEGFR inhibitor combination arrests a doxorubicin resistant lung metastatic osteosarcoma in a PDOX mouse model. Scientific reports. 2021. 11. 1. 8583-8583
  • Yoshihiro Araki, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Kensaku Abe, Yuta Taniguchi, Hirotaka Yonezawa, et al. Author Correction: The number of osteoclasts in a biopsy specimen can predict the efficacy of neoadjuvant chemotherapy for primary osteosarcoma. Scientific reports. 2021. 11. 1. 8831-8831
  • Takashi Higuchi, Qinghong Han, Norihiko Sugisawa, Jun Yamamoto, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Kentaro Igarashi, Michael Bouvet, et al. Combination Methionine-methylation-axis Blockade: A Novel Approach to Target the Methionine Addiction of Cancer. Cancer genomics & proteomics. 2021. 18. 2. 113-120
  • Shinji Miwa, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Kentaro Igarashi, Kaoru Tada, Takashi Higuchi, Hirotaka Yonezawa, Sei Morinaga, Yoshihiro Araki, et al. Diagnostic accuracies of intraoperative frozen section and permanent section examinations for histological grades during open biopsy of bone tumors. International journal of clinical oncology. 2021. 26. 3. 613-619
MISC (163):
Lectures and oral presentations  (74):
  • Efficacy of olaratumab in combination with different standard chemotherapeutic regimens in soft tissue sarcoma treatment: in vivo study using patient-derived orthotopic xenograft (PDOX) mouse model
    (13th Asia Pacific Musculoskeletal Tumor Society Meeting)
  • Activation and induction of PPARγ using a non-steroidal inflammatory drug inhibits cell progression in chondrosarcoma cells
    (13th Asia Pacific Musculoskeletal Tumor Society Meeting)
  • 患者由来組織同所移植モデル (patient-derived orthotopic xenograft: PDOX)を用いた解析
  • 軟部肉腫に対するolaratumabの可能性 -patient-derived orthotopic xenograft (PDOX)マウスモデルによる解析-
    (The 35th Annual Research Meeting of the Japanese Orthopaedic Association)
  • 軟骨肉腫に対する非ステロイド性抗炎症薬によるperoxisome proliferator-activated receptorγ (PPARγ)を標的とした新しい治療戦略の可能性
    (The 35th Annual Research Meeting of the Japanese Orthopaedic Association)
Education (2):
  • - 2018 Kanazawa University
  • - 2009 Kanazawa University
Professional career (1):
  • 医学博士 (金沢大学大学院医薬保健学総合研究科)
Work history (8):
  • 2020/04 - 現在 Japanese Red Cross Kanazawa Hospital Orahopaedic Surgery vice manager
  • 2020/01 - 2020/03 Kanazawa University Hospital Department of Orthopaedic Surgery Medical staff
  • 2017/11 - 2019/12 University of California San Diego (UCSD) Department of Surgery Visiting scholar
  • 2013/10 - 2017/10 金沢大学付属病院 整形外科 医員
  • 2012/04 - 2013/09 富山県済生会高岡病院 整形外科 医員
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Awards (4):
  • 2021/06 - Kanazawa University Juzen Medical Society 1st Juzen Medical Encouragement Award Mechanism of metastasis and new treatment development in sarcoma
  • 2018/10 - 39th Société Internationale de Chirurgie Orthopédique et de Traumatologie(SICOT)Orthopaedic World Congress The Lester Lowe SICOT Award
  • 2018/09 - Kanazawa University President Award Anti-tumor effects of a non-steroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression
  • 2017/10 - Society Encouragement Award
Association Membership(s) (5):
International Society Of Limb Salvage ,  Société Internationale de Chirurgie Orthopédique et de Traumatologie International Society of Orthopaedic Surgery and Traumatology ,  JAPAN SOCIETY OF CLINICAL ONCOLOGY ,  The Central Japan Association of Orthopaedic Surgery and Traumatology ,  THE JAPANESE ORTHOPAEDIC ASSOCIATION
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