Hirata Tetsuya

Research field (1)： Structural biochemistry

Research keywords (7)： Forward genetic screening , Palmitoylation , Biochemistry , Glycoscience , GPI-anchor , N-glycosylation , Neuroscience

Research theme for competitive and other funds (11)：

2021 - 2024 Mechanism for diversifying the branched structure of GPI elucidated by interdisciplinary research in glycochemistry and glycobiology
2020 - 2023 GPIアンカー側鎖の生理機能と疾患との関連の解明
2021 - 2022 神経分化にともなう糖脂質 GPI の糖鎖構造変化の意義の解明
2021 - 2022 化学合成した糖脂質GPIアンカーを基質としたGPI糖鎖生合成メカニズムの解明
2020 - 2022 糖脂質GPIの糖鎖構造多様化メカニズムの解明

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Papers (29)：

Takahiro Takekiyo, Shuto Yamada, Takuya Uto, Masaharu Nakayama, Tetsuya Hirata, Takeru Ishizaki, Kosuke Kuroda, Yukihiro Yoshimura. Protein Cryoprotectant Ability of the Aqueous Zwitterionic Solution. The journal of physical chemistry. B. 2024. 128. 2. 526-535
Takahiro Takekiyo, Shuto Yamada, Tetsuya Hirata, Takeru Ishizaki, Kosuke Kuroda, Yukihiro Yoshimura. Relationship Between Cryoprotectant Potential and Protein Hydration in Aqueous Zwitterionic Solutions. Biopolymers. 2024
Atsushi Kobayashi, Tetsuya Hirata, Taishi Shimazaki, Yoshiko Munesue, Keisuke Aoshima, Takashi Kimura, Junko Nio-Kobayashi, Rie Hasebe, Atsuko Takeuchi, Yuichi Matsuura, et al. A point mutation in GPI-attachment signal peptide accelerates the development of prion disease. Acta neuropathologica. 2023. 145. 5. 637-650
Tetsuya Hirata, Yoichiro Harada, Koichiro M. Hirosawa, Yuko Tokoro, Kenichi G.N. Suzuki, Yasuhiko Kizuka. N-Acetylglucosaminyltransferase-V (GnT-V)-enriched small extracellular vesicles mediate N-glycan remodeling in recipient cells. iScience. 2022. 105747-105747
Tetsuya Hirata, Jing Yang, Seita Tomida, Yuko Tokoro, Taroh Kinoshita, Morihisa Fujita, Yasuhiko Kizuka. ER entry pathway and glycosylation of GPI-anchored proteins are determined by N-terminal signal sequence and C-terminal GPI-attachment sequence. The Journal of biological chemistry. 2022. 298. 10. 102444-102444

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MISC (5)：

大須賀玲奈, 平田哲也, 長江雅倫, 木塚康彦. 糖転移酵素GnT-Vに特異的な非触媒ドメインを介した糖タンパク質基質認識機構. 日本生化学会大会プログラム・講演要旨集. 2021. 94回. [2T13m-064)]
大須賀玲奈, 平田哲也, 長江雅倫, 木塚康彦, 木塚康彦. Mechanism of substrate recognition by GnT-V. 日本糖質学会年会要旨集. 2021. 40th
富田晟太, 高田実咲, 平田哲也, 長江雅倫, 中の三弥子, 木塚康彦, 木塚康彦. FUT8にユニークなSH3ドメインの機能解明. 日本生化学会大会(Web). 2020. 93rd
富田晟太, 平田哲也, 長江雅倫, 木塚康彦, 木塚康彦. FUT8 SH3ドメインの機能解析. 日本糖質学会年会要旨集. 2019. 38th
T. Hirata, Y. Fukata, M. Fukata. Palmitoylation/depalmitoylation enzymes in neuroscience research. Biochemistry. 2018. 90. 2. 125-137

Education (2)：

Professional career (1)：

Work history (5)：

2022/04 - 現在 Duke University Department of Biochemistry, School of Medicine Research Scholar
2019/04 - 2022/03 Gifu University G-CHAIN Specially-Appointed Assistant Professor
2017/04 - 2019/03 National Institute for Physiological Sciences Division of Membrane Physiology Project Assistant Professor
2016/04 - 2017/03 Osaka University Research Institute for Microbial Diseases Specially Appointed Researcher (Full time)
2014/04 - 2016/03 Osaka University Research Institute for Microbial Diseases JSPS Research Fellow (DC2)

Committee career (2)：

Awards (2)：

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