NAKAGAWA Takayuki

ナカガワタカユキ | NAKAGAWA Takayuki

Affiliation and department：
Job title： Associate Professor

Research field (1)： Veterinary medicine

Research theme for competitive and other funds (27)：

2023 - 2028 犬腫瘍に対する個別化併用がん免疫療法の開発
2024 - 2027 犬口腔扁平上皮癌の根治を目指した全身投与可能な核酸療法の確立
2023 - 2026 犬膀胱癌に対するHER2を標的とした抗体療法の開発
2023 - 2025 犬悪性黒色腫のリバースモデリングによる転移阻害療法の開発
2023 - 2025 Investigating the immune and cytoreductive activities of gilvetmab alone and in combination with indoleamine 2,3-dioxygenase inhibition in canine urothelial carcinoma of the bladder.

2021 - 2024 高分子薬の有効化に寄与する癌微小環境改善薬の開発

2021 - 2024 Elucidating the pathophysiological factors for the clinical application using an artificial intelligence analysis to the snRNA transcriptome data of canine tumors

2020 - 2024 犬固形腫瘍に有効なCAR-T細胞のシグナル分子の解明

2021 - 2023 バーチャルリアリティを用いた体験型獣医外科手術教育法の開発

2020 - 2023 Establishment of a novel combination immunotherapy focusing on molecular abnormalities of canine bladder cancer

2019 - 2021 Attempt of the T cell restoration of youth by metabolic control using metformin. Overcoming a limit of the TIL therapy.

2018 - 2021 Development of innovative nucleic acid medicine using EPR enhancer iNaD

2021 - 2021 VA-ECMOとアフェレシスの融合による呼吸・代謝一体型の新たな緊急生命機能維持装置の開発~動物種差を超える獣医学的見地からの医工獣連携

2017 - 2020 Establishment of smart-diagnosis&treatment for canine tumor by exosome

2020 - 2020 バーチャルリアリティ(VR)を用いた小動物外科手術教材の作製と教育効果の検証

2016 - 2019 Establishment of "Liquid Staging" using urine samples

2015 - 2018 Development of the combined immune-modulatory therapies for canine cancer

2015 - 2018 磁気ナノ粒子によるセンチネルリンパ節の特定とがん転移の迅速診断法の開発

2015 - 2017 Pioneering study of genome analysis in canine malignant tumors to establish a clinical genome-based diagnostics

2015 - 2017 Functional analysis of Exosome in Canine Tumor

2014 - 2017 Identification and clinical application of cancer stem cells derived from canine refractory cancers

2013 - 2017 Development of a magnetic probe for identifying the sentinel lymph node

2013 - 2016 New approach of cancer research; mitochondrial respiratory chain inhibitors as a new therapeutic target.

2012 - 2014 Is "steric hindrance effect" the possible new concept for tumor metastasis mechanism?

2010 - 2011 クルクミン食併用による新たな抗癌剤治療プロトコール開発に向けた安全性研究

2008 - 2011 Comparative analysis on metastasis-associated molecules in malignant tumors with different metastatic routes such as canine mammary cancer and osteosarcoma

2009 - 2010 Clinical significance of the Epithelial-Mesenchymal Transition in the malignant transformation of canine mammary gland tumors.

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Papers (201)：

Md Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Daiki Kato, Takayuki Nakagawa, Mohammad Arif, Naoki Miura. Hypoxia-related Y RNA fragments as a novel potential biomarker for distinguishing metastatic oral melanoma from non-metastatic oral melanoma in dogs. The veterinary quarterly. 2024. 44. 1. 1-8
Shotaro Eto, Daiki Kato, Kohei Saeki, Takaaki Iguchi, Qin Shiyu, Satoshi Kamoto, Ryohei Yoshitake, Masahiro Shinada, Namiko Ikeda, Masaya Tsuboi, et al. Comprehensive Analysis of the Tumour Immune Microenvironment in Canine Urothelial Carcinoma Reveals Immunosuppressive Mechanisms Induced by the COX-Prostanoid Cascade. Veterinary and comparative oncology. 2024
Md Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Mohammad Arif, Indre Jasineviciute, Daiki Kato, Takayuki Nakagawa, Naoki Miura. Upregulation and functional roles of miR-450b in canine oral melanoma. Non-coding RNA research. 2024. 9. 2. 376-387
Taiki Kato, Masashi Sakurai, Kenji Watanabe, Yoichi Mizukami, Takayuki Nakagawa, Kenji Baba, Takuya Mizuno, Masaya Igase. Identification of hypoxia-induced metabolism-associated genes in canine tumours. Veterinary and comparative oncology. 2024
Kosei Sakai, Daiki Kato, Junka Yoshinaka, Yosuke Takahashi, Namiko Ikeda, Susumu Aoki, Takaaki Iguchi, Shingo Ishikawa, Norio Yamagishi, Shunsuke Shimamura, et al. Effects of trastuzumab emtansine on canine urothelial carcinoma cells in vitro and in vivo. Veterinary and comparative oncology. 2024. 22. 2. 230-238

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MISC (171)：

中川貴之. VA-ECMOとアフェレシスの融合による呼吸・代謝一体型の新たな緊急生命機能維持装置の開発動物種差を超える獣医学的見地からの医工獣連携. 医科学応用研究財団研究報告. 2024. 41. 173-176
中川貴之. いま1度TNM分類とステージ分類を整理する総論. Joncol: Japanese Journal of Veterinary Clinical Oncology. 2024. 20. 1. 105-113
高橋洋介, 中川貴之. 【がん手術に伴う合併症(後遺症)その2~起こさないコツと起こったときの対処法】人工肛門・大腸(部分切除). Veterinary Oncology. 2024. 11. 1. 20-33
加藤大樹, 櫻井優, 渡邉健司, 水上洋一, 中川貴之, 水野拓也, 伊賀瀬雅也. イヌ腫瘍における低酸素環境により誘導される代謝関連遺伝子の同定(Identification of hypoxia-induced metabolism-associated genes in canine tumors). 日本癌学会総会記事. 2023. 82回. 562-562
渋谷周作, 大浜剛, 中川貴之, 水野拓也. IGF2BP2がイヌの乳がん細胞の増殖に及ぼす影響の解析. 日本獣医学会学術集会講演要旨集. 2023. 166回. 175-175

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Patents (4)：

Education (4)：

2001 - 2005 The University of Tokyo Graduate School of Agricultural and Life Sciences Veterinary Medical Sciences
1997 - 2001 The University of Tokyo Faculty of Agriculture Veterinary Medical Sciences
1993 - 1995 The University of Tokyo Faculty of Economics Department of Economics
1991 - 1993 The University of Tokyo College of Arts and Sciences Human Sciences II

Professional career (1)：

Ph.D. (The University of Tokyo)

Work history (7)：

2015/12 - 現在 The University of Tokyo Graduate School of Agricultural and Life Sciences Associate professor
2010/01 - 2015/11 The University of Tokyo Graduate School of Agricultural and Life Sciences Assistant professor
2011/08 - 2011/12 National Institutes of Health National Cancer Institute Visiting Fellow
2007/04 - 2009/12 The University of Tokyo Graduate School of Agricultural and Life Sciences Assistant professor
2006/08 - 2007/03 The University of Tokyo Graduate School of Agricultural and Life Sciences Research assistant

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