Rchr
J-GLOBAL ID:201901009524130060
Update date: Apr. 14, 2024
Imai Hirotatsu
イマイ ヒロタツ | Imai Hirotatsu
Affiliation and department:
Research field (2):
Biophysics
, Molecular biology
Research keywords (3):
Translation
, RNA
, Ribosome
Research theme for competitive and other funds (5):
- 2024 - 2027 統合的ストレス応答がリボソームを不活化する分子機構の解明
- 2021 - 2024 リボソームストークをハブとする翻訳関連因子プールの機能動態解明
- 2022 - 2023 mRNAの転写量と翻訳量を同時に解析できる手法の開発
- 2020 - 2023 高速原子間力顕微鏡で解き明かすリボソームの機能ダイナミクス
- 2016 - 2019 翻訳伸長段階におけるリボソームストークタンパク質複合体の分子動態解析
Papers (8):
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Imai H, Utsumi D, Torihara H, Kenzo T, Kuroyanagi H, Yamashita A. Simultaneous measurement of nascent transcriptome and translatome using 4-thiouridine metabolic RNA labeling and translating ribosome affinity purification. Nucleic Acids Research. 2023. 51. e76
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Yang L, Lee KM, Yu CWH, Imai H, Choi AKH, Banfield DK, Ito K, Uchiumi T, Wong KB. The flexible N-terminal motif of uL11 unique to eukaryotic ribosomes interacts with P-complex and facilitates protein translation. Nucleic Acids Research. 2022. 50. 5335-5348
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Imai H, Uchiumi T, Kodera N. Direct visualization of translational GTPase factor pool formed around the archaeal ribosomal P-stalk by high-speed atomic force microscopy. Proceedings of the National Academy of Sciences of the U. S. A. 2020. 117. 32386-32394
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Kimura T, Tsuchida-Mayama T, Imai H, Okajima K, Ito K, Sakai T. Arabidopsis ROOT PHOTOTROPISM2 Is a Light-Dependent Dynamic Modulator of Phototropin1. The Plant Cell. 2020. 10.1101/862649
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Maruyama K*, Imai H*, Kawamura M, Ishino S, Ishino Y, Ito K†, Uchiumi T†. Switch of the interactions between the ribosomal stalk and EF1A in the GTP- and GDP-bound conformations. Scientific Reports. 2019. 9. 14761
more...
MISC (2):
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Hirotatsu Imai. Recruitment of translation factors by the tentacles of ribosomes. Journal of Japanese Biochemical Society. 2022. 94. 5. 739-742
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市邨晃久, 笠原杏子, 今井大達, 上原祐二, 西川周一, 内海利男, 伊東孝祐. ペプチジルtRNA加水分解酵素・プロテアソーム輸送タンパク質複合体のX線結晶構造解析. 日本分子生物学会年会プログラム・要旨集(Web). 2018. 41st
Books (2):
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疾患原因遺伝子・タンパク質の解析技術と創薬/診断技術への応用
技術情報協会 2022
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相分離生物学の全貌
東京化学同人 2020
Lectures and oral presentations (6):
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小胞体ストレス応答におけるRNAの新規合成量と翻訳量の同時測定
(第46回日本分子生物学会年会 2023)
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High-speed AFM visualizes translational GTPase factor pool formed around the ribosomal P-stalk
(The 60th Annual Meeting of the Biophysical Society of Japan 2022)
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Direct visualization of translational GTPase factor pool formed around archaeal ribosomal P-stalk by high-speed AFM
(2020)
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ATP加水分解酵素ABCE1とリボソームストークタンパク質間の機能的相互作用
(第20回日本RNA学会年会 2018)
-
Functional role of the ribosomal arm-like proteins.
(JSRC 2015 Research Seminar on Biology 2015)
more...
Education (3):
- 2016 - 2019 Niigata University Graduate School of Science and Technology
- 2014 - 2016 Niigata University Graduate School of Science and Technology
- 2010 - 2014 Niigata University Faculty of Science Department of Biology
Professional career (1):
- Doctor of Science (Niigata University)
Work history (5):
- 2023/04 - 現在 University of the Ryukyus Graduate School of Medicine Research Associate
- 2021/05 - 2023/03 University of the Ryukyus Graduate School of Medicine Project Research Associate
- 2020/04 - 2021/04 Kanazawa University Nano-LSI JSPS Research Fellow (PD)
- 2019/04 - 2020/03 Kanazawa University Nano-LSI Postdoc
- 2016/04 - 2019/03 Niigata University Graduate School of Science and Technology JSPS Research Fellow (DC1)
Awards (5):
- 2020/12 - 日本生体エネルギー研究会 第46回討論会 口頭発表優秀賞
- 2019/03 - 新潟大学 学長表彰
- 2016/12 - 第39回日本分子生物学学会年会 優秀ポスター賞
- 2015/08 - 第55回生命科学夏の学校 特別賞
- 2014/09 - RNAフロンティアミーティング2014 ベストプレゼンテーション賞
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