Iguchi Yohei

イグチヨウヘイ | Iguchi Yohei

Affiliation and department：

Research field (1)： Neurology

Research keywords (5)： Amyotrophic Lateral Sclerosis , Chemistry , Biology , Neuroscience , Neurodegeneration

Research theme for competitive and other funds (10)：

2023 - 2026 Elucidation of temporal alteration in motor neuron-oligodendrocyte interaction in motor neuron diseases
2022 - 2025 Study of synaptic pahtology caused by FUS in amyotrophic lateral sclerosis
2022 - 2025 Development of neuronal aggregates-targeted therapeutics
2022 - 2024 遠位型遺伝性運動ニューロパチー7型の病態解明と病態抑止療法の開発
2021 - 2023 Wide-field Ca imaging and trans-omics for mouse model of Lewy body disease

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Papers (59)：

Yuki Fukami, Masahiro Iijima, Haruki H Koike, Satoru Yagi, Soma Furukawa, Naohiro Mouri, Jun Ouchida, Ayuka Murakami, Madoka Iida, Satoshi Yokoi, et al. Autoantibodies Against Dihydrolipoamide S-Acetyltransferase in Immune-Mediated Neuropathies. Neurology(R) neuroimmunology & neuroinflammation. 2024. 11. 2. e200199
Seiji Watanabe, Yuri Murata, Yasuyoshi Oka, Kotaro Oiwa, Mai Horiuchi, Yohei Iguchi, Okiru Komine, Akira Sobue, Masahisa Katsuno, Tomoo Ogi, et al. Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 47. e2315347120
Kotaro Oiwa, Seiji Watanabe, Kazunari Onodera, Yohei Iguchi, Yukako Kinoshita, Okiru Komine, Akira Sobue, Yohei Okada, Masahisa Katsuno, Koji Yamanaka. Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis. Science Advances. 2023. 9. 31
Haruki Koike, Yohei Iguchi, Kentaro Sahashi, Masahisa Katsuno. Neutrophil extracellular traps: from antimicrobial innate immunity to the development of chemotherapy-induced peripheral neuropathy. EBioMedicine. 2023. 90. 104526-104526
Koyo Tsujikawa, Kohei Hamanaka, Yuichi Riku, Yuki Hattori, Norikazu Hara, Yohei Iguchi, Shinsuke Ishigaki, Atsushi Hashizume, Satoko Miyatake, Satomi Mitsuhashi, et al. Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology. Science advances. 2022. 8. 21. eabm5029

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MISC (18)：

辻河高陽, 濱中耕平, 陸雄一, 陸雄一, 服部祐季, 井口洋平, 小林憲太, 池内健, 宮田卓樹, 松本直通, et al. アクチン結合蛋白フィラミンAはタウ凝集を促進し,進行性核上性麻痺の病理に関連する. 日本神経化学会大会抄録集(Web). 2022. 65th
Katsuno Masahisa, Sahashi Kentaro, Iguchi Yohei, Hashizume Atsushi. Preclinical progression of neurodegenerative diseases. NAGOYA JOURNAL OF MEDICAL SCIENCE. 2018. 80. 3. 289-298
Sahashi K, Kondo N, Iida M, Nakatsuji H, Tohnai G, Iguchi Y, Sobue G, Katsuno M. Understanding of the role of proteinaceous inclusions in spinal and bulbar muscular atrophy. JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017. 381. 709-709
Iguchi Y, Eid L, Parent M, Riku Y, Kawai K, Yoshida M, Katsuno M, Sobue G, Julien J. P. The role of TDP-43 secretion in association with exosomes. JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017. 381. 208-209
Shinsuke Ishigaki, Akio Masuda, Yusuke Fujioka, Yohei Iguchi, Masahisa Katsuno, Akihide Shibata, Fumihiko Urano, Gen Sobue, Kinji Ohno. Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions (vol 2, 529, 2012). SCIENTIFIC REPORTS. 2013. 3

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Books (6)：

筋萎縮性側索硬化症の病態解明の現況・展望
メディカルレビュー社 2021
運動ニューロン疾患の進歩
神経治療 2013
孤発性ALSの分子標的治療への展望
BIO Clinica(バイオクリニカ) 2012
筋萎縮性側索硬化症のバイオマーカー研究
実験医学 2012
TDP-43のloss of functionによる神経障害
Cognition and Dementia 2011

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Lectures and oral presentations (5)：

TDP-43代謝におけるエクソソームの役割
(第59回日本神経学会学術大会 2018)
Emerging roles of exosomes in TDP-43 proteinopathy
(PACTALS”and“Brain Protein Aging and Dementia Control”Project Joint Meeting 2017)
Exosome secretion as a key pathway for clearance of pathological TDP-43
(12th ANNUAL ALS CANADA RESEARCH FORUM 2016)
TDP-43 is secreted in association with exosomes
(26th international symposium on ALS/MND 2015)
Role of TDP-43 in the pathogenesis of sporadic ALS
(8th Symposium of Fondation André-Delambre Amyotrophic lateral sclerosis Canada Quebec 2012)

Professional career (1)：

MD, PhD

Association Membership(s) (3)：

THE JAPAN NEUROSCIENCE SOCIETY , JAPANESE SOCIETY OF NEUROLOGY , THE JAPANESE SOCIETY OF INTERNAL MEDICINE

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