Kobayashi Nobuhide

コバヤシノブヒデ | Kobayashi Nobuhide

Affiliation and department：
Job title：助教
Homepage URL (1)： https://www.idonate-all.jp/donation/detail/IORJAQxQ3qon

Research field (4)： Bacteriology , Immunology , Cell biology , Molecular biology

Research keywords (10)： gut microbiota , membrane vesicle , immunology , organoid , membrane traffic , Clostridium botulinum , M cell , intestinal epithelial cell , mucosal immunology , bacteriology

Research theme for competitive and other funds (12)：

2023 - 2026 乳児ボツリヌス症発症機構の全容解明に向けた基盤研究
2023 - 2026 共生細菌叢による外来芽胞の定着抵抗性を利用した乳児ボツリヌス症の予防・治療法の開発に向けた基盤研究
2024 - 2025 腸内細菌によるボツリヌス菌感染防御機構の解析
2022 - 2025 Role of membrane vesicles produced by the intestinal microbiota in intestinal homeostasis.
2021 - 2024 腸管感染型ボツリヌス症を制御する腸内因子のin vivoを中心とした解析

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Papers (11)：

Takuhiro Matsumura, Mayu Kitamura, Sho Amatsu, Aki Yamaguchi, Nobuhide Kobayashi, Masahiro Yutani, Yukako Fujinaga. Neutralization mechanism of human monoclonal antibodies against type B botulinum neurotoxin. Microbiology and Immunology. 2024
Nobuhide Kobayashi, Kimihiro Abe, Sachiyo Akagi, Mayu Kitamura, Yoshitake Shiraishi, Aki Yamaguchi, Masahiro Yutani, Sho Amatsu, Takuhiro Matsumura, Nobuhiko Nomura, et al. Membrane Vesicles Derived From Clostridium botulinum and Related Clostridial Species Induce Innate Immune Responses via MyD88/TRIF Signaling in vitro. Frontiers in Microbiology. 2022. 13. 720308-720308
Shunsuke Kimura, Yutaka Nakamura, Nobuhide Kobayashi, Katsuyuki Shiroguchi, Eiryo Kawakami, Mami Mutoh, Hiromi Takahashi-Iwanaga, Takahiro Yamada, Meri Hisamoto, Midori Nakamura, et al. Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity. Nature communications. 2020. 11. 1. 234-234
Kobayashi, N, Takahashi, D, Takano, S, Kimura, S, Hase, K. The Roles of Peyer’s Patches and Microfold Cells in the Gut Immune System: Relevance to Autoimmune Diseases. Frontiers in Immunology. 2019. 10. 2345
Motoyoshi Nagai, Ryotaro Noguchi, Daisuke Takahashi, Takayuki Morikawa, Kouhei Koshida, Seiga Komiyama, Narumi Ishihara, Takahiro Yamada, Yuki I. Kawamura, Kisara Muroi, et al. Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses. Cell. 2019. 178. 5. 1072-1087.e14

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MISC (2)：

Nobuhide Kobayashi, Koji Hase. Roles of various antigen sampling mechanism on mucosal surface. Clinical immunology & allergology. 2018. 69. 5. 482-488
Ishihara Narumi, Kobayashi Nobuhide, Hase Koji. INTESTINAL M CELLS CONTRIBUTE TO THE MAINTENANCE OF MUCOSAL BARRIER FUNCTIONS AND IMMUNE HOMEOSTASIS. Japanese Journal of Allergology. 2018. 67. 3. 171-178

Lectures and oral presentations (16)：

Membrane vesicles derived from Clostridium botulinum induce inflammatory responses and disrupt intestinal barrier.
(2024)
Identification of the intestinal bacteria that protect against Clostridium botulinum infection
(2024)
ボツリヌス菌感染防御効果を有するヒト腸内細菌の単離
(第28回腸内細菌学会学術集会 2024)
ボツリヌス菌感染防御に寄与するヒト腸内細菌の同定
(第3回腸内デザイン学会年会 2023)
ボツリヌス菌感染感受性を特徴づける腸内細菌叢の解明
(第60回日本細菌学会中部支部会総会 2023)

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Education (3)：

2016 - 2019 Keio University
2011 - 2013 東北大学大学院生命科学研究科生命機能科学専攻前期博士課程(佐竹正延教授)
2007 - 2011 Tohoku University Faculty of Science Department of Biology

Professional career (1)：

PhD (Keio University)

Work history (4)：

2019/10 - 現在 Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine
2019/04 - 2019/09 Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine
2016/04 - 2019/03 日本学術振興会特別研究員DC1
2013/04 - 2016/03 Fukushima Agricultural Technology Centre

Awards (7)：

2023/11 - 腸内デザイン学会第3回腸内デザイン学会・優秀発表賞
2020/08 - 日本バイオフィルム学会・日本細菌学会中部支部第34回日本バイオフィルム学会学術集会・第57回日本細菌学会中部支部総会若獅子賞
2020/02 - 日本細菌学会第93回日本細菌学会総会優秀発表賞
2019/03 - Japanese Society for Immunology Tadamitsu Kishimoto International Travel Award
2019/01 - 日本骨免疫学会第4回日本骨免疫学会ウィンターセミナー優秀演題賞

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