Nogawa Toshihiko

Research field (1)： Environmental and pharmaceutical development resources

Research theme for competitive and other funds (6)：

2020 - 2023 Elucidation of molecular basis of biosynthesis with the aim of expanding the diversity of natural products
2020 - 2023 ブロスライブラリーの拡張と新規活性物質探索に向けた多変量スクリーニング系の構築
2017 - 2020 Construction of a fraction lirary with wide diversity and application for discovery of new bioactive compounds
2016 - 2019 Development of small-molecule inhibitors targeting glucose-independent cancer metabolism
2014 - 2017 Application of microbial metabolite fraction library and NPPlot on discovery of new metabolites

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Papers (72)：

Katsuyuki Sakai, Yushi Futamura, Toshihiko Nogawa, Yuzhu Zhao, Hiroyuki Koshino, Hiroyuki Osada, Shunji Takahashi. Production of Kinanthraquinone D with Antimalarial Activity by Heterologous Gene Expression and Biotransformation in Streptomyces lividans TK23. Journal of Natural Products. 2024. 87. 4. 855-860
Toshihiko Nogawa, Naoki Kato, Takeshi Shimizu, Akiko Okano, Yushi Futamura, Shunji Takahashi, Hiroyuki Koshino, Hiroyuki Osada. Wakodecaline C, new tetrahydrofuran-fused decalin metabolite isolated from fungus Pyrenochaetopsis sp. RK10-F058. The Journal of antibiotics. 2023. 76. 6. 346-350
Makoto Kawatani, Harumi Aono, Sayoko Hiranuma, Takeshi Shimizu, Makoto Muroi, Toshihiko Nogawa, Tomokazu Ohishi, Shun-Ichi Ohba, Manabu Kawada, Kanami Yamazaki, et al. Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling. Oncology research. 2023. 31. 6. 833-844
Takayuki Motoyama, Toshihiko Nogawa, Takeshi Shimizu, Makoto Kawatani, Takeshi Kashiwa, Choong-Soo Yun, Daisuke Hashizume, Hiroyuki Osada. Fungal NRPS-PKS Hybrid Enzymes Biosynthesize New gamma-Lactam Compounds, Taslactams A-D, Analogous to Actinomycete Proteasome Inhibitors. ACS CHEMICAL BIOLOGY. 2023
Naoki Kato, Kana Ebihara, Toshihiko Nogawa, Yushi Futamura, Kazue Inaba, Akiko Okano, Harumi Aono, Yuuta Fujikawa, Hideshi Inoue, Kazuhiko Matsuda, et al. cis-Decalin-containing tetramic acids as inhibitors of insect steroidogenic glutathione S-transferase Noppera-bo. PloS one. 2023. 18. 8. e0290851

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MISC (28)：

野川俊彦, RAWA Mira Syahfriena Amir, RAWA Mira Syahfriena Amir, 岡野亜紀子, 二村友史, 中村健道, WAHAB Habibah A., 長田裕之. New Peptaibols Isolated from a Fungus Trichoderma sp. RK10-F026 as Culture Condition Depending Metabolites. 質量分析総合討論会講演要旨集. 2021. 69th
本山高幸, 野川俊彦, 清水猛, 川谷誠, 二村友史, YUN Choong-Soo, 長田裕之. Isolation of new bioactive natural products by using homologs of a new type secondary metabolism enzyme TAS1. 日本農芸化学会大会講演要旨集(Web). 2020. 2020
古山祐貴, 古山祐貴, 本山高幸, 野川俊彦, 鎌倉高志, 長田裕之. Functional analysis of secondary metabolites of the rice blast fungus induced by actinomycetal antibiotics. 日本農芸化学会大会講演要旨集(Web). 2020. 2020
野川俊彦, 寺井淳高, 新家一男, 池田治生, 高橋俊二, 長田裕之. Structures of new verticilactam derivatives by heterologous expression. 日本農芸化学会大会講演要旨集(Web). 2020. 2020
野川俊彦. 糸状菌からのデカリン含有化合物の単離と構造. 理研シンポジウムデカリン化合物の化学合成と生合成令和元年. 2019

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