Rchr
J-GLOBAL ID：201901010912517200   Update date: Feb. 01, 2024

Nishimori Shigeki

ニシモリ シゲキ | Nishimori Shigeki
Affiliation and department：
Teikyo University Faculty of Medical Technology Department of Sport and Medical Science

About Teikyo University Faculty of Medical Technology Department of Sport and Medical Science


Other affiliations (1)：
  • Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
Research field  (1)： Pathobiochemistry
Research keywords  (4)： Bone Development ,  Chondrocyte Development ,  Parathyroid hormone related protein ,  Mouse Genetics
Research theme for competitive and other funds  (8)：
  • 2023 - 2026 PTH/PTHrP受容体の下流で働く新規情報伝達分子Sik3に関する基礎研究
  • 2023 - 2024 副甲状腺ホルモン受容体の下流で骨及び軟骨の分化を制御する細胞内シグナル経路の解明
  • 2020 - 2023 Investigation of mechanisms how the PTH/PTHrP/Sik pathway reglates endochondral bone formation
  • 2020 - 2022 The roles of Salt Inducible Kinases (Sik) in endochondral bone formation
  • 2018 - 2020 PTH INVERSE AGONISTS AS THERAPY FOR JANSEN’S DISEASE
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Papers (28)：
  • Shigeki Nishimori, Marc N. Wein, Henry M. Kronenberg. PTHrP targets salt-inducible kinases, HDAC4 and HDAC5, to repress chondrocyte hypertrophy in the growth plate. Bone. 2021. 142. 115709-115709
  • Meng Xie, Pavel Gol'din, Anna Nele Herdina, Jordi Estefa, Ekaterina V Medvedeva, Lei Li, Phillip T Newton, Svetlana Kotova, Boris Shavkuta, Aditya Saxena, et al. Secondary ossification center induces and protects growth plate structure. eLife. 2020. 9
  • Nishimori S, O'Meara MJ, Castro C, Noda H, Cetinbas M, da Silva Martins J, Ayturk U, Brooks DJ, Bruce M, Nagata M, et al. Salt-inducible kinases dictate parathyroid hormone receptor action in bone development and remodeling. The Journal of clinical investigation. 2019. 129. 12. 5187-5203
  • Nishimori S, Lai F, Shiraishi M, Kobayashi T, Kozhemyakina E, Yao TP, Lassar AB, Kronenberg HM. PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy. JCI insight. 2019. 4. 5
  • Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, et al. Corrigendum: SIKs control osteocyte responses to parathyroid hormone. Nature communications. 2017. 8. 14745
ｍore...
MISC (50)：
  • Shigeki Nishimori, Marc N. Wein, Henry M. Kronenberg. Actions of PTHrP, HDAC4, and SIK3 to Regulate Chondrocyte Hypertrophy. JOURNAL OF BONE AND MINERAL RESEARCH. 2017. 32. S68-S68
  • Garyfallia Papaioannou, Fatemeh Mirzamohammadi, Shigeki Nishimori, Marc Wein, Henry Kronenberg, Eric N. Olson, Tatsuya Kobayashi. MicroRNA-140 provides robustness to the regulation of hypertrophic chondrocyte differentiation by the PTHrP-HDAC4 pathway. JOURNAL OF BONE AND MINERAL RESEARCH. 2014. 29. S40-S40
  • Shigeki Nishimori, Forest Lai, Marc Wein, Elena Kozhemyakina, Eric Olson, Andrew Lassar, Henry Kronenberg. Complete Suppression of PTHrP Signaling in Chondrocytes in the Histone Deacetylase 4 and 5 Double Knockout Mouse. JOURNAL OF BONE AND MINERAL RESEARCH. 2013. 28
  • 西森茂樹, 三宅康史. 重症患者の全身管理. 月刊レジデント. 2009. 2. 10. 110-117
  • K. L. Conen, S. Nishimori, S. Provot, H. M. Kronenberg. Overexpression of the Transcriptional Cofactor Lbh Impaires Angiogenesis and Endochondral Bone Formation During Fetal Bone Development in Chickens. JOURNAL OF BONE AND MINERAL RESEARCH. 2008. 23. S244-S244
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Books (35)：
  • 治療薬UP-TO-DATE 2021
    メディカルレビュー社 2021 ISBN:9784779225086
  • 治療薬UP-TO-DATE 2020
    メディカルレビュー社 2020 ISBN:4896004582
  • 治療薬UP-TO-DATE 2019
    メデイカルレビュー社 2019 ISBN:9784779220654
  • 治療薬UP-TO-DATE 2018
    メデイカルレビュー社 2018 ISBN:9784779219788
  • 治療薬UP-TO-DATE 2017
    メデイカルレビュー社 2017 ISBN:9784779217920
ｍore...
Lectures and oral presentations  (19)：
  • Rising Stars in Skeletal Biology
    (第38回日本骨代謝学会学術集会 2020)
  • PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy
    (Metabolic Bone Disease Meeting 2019 in Seoul 2019)
  • Continuous infusion of PTHrP(7-36) Inverse Agonist Ameliorates the Delay in Endochondral Bone Formation in a Mouse Model of Jansen’s Metaphyseal Chondrodysplasia
    (The American Society for Bone and Mineral Research, Montreal 2018)
  • PTHrP Targets Salt-induced Kinases to Regulate Chondrocyte Differentiation
    (The American Society for Bone and Mineral Research, Montreal 2018)
  • Roles of PTHrP, HDAC4, and Salt-inducible Kinase 3 (Sik3) to Regulate Chondrocyte Hypertrophy
    (American Academy of Orthopaedic Surgeons, Chicago 2018)
ｍore...
Education (2)：
  • 1997 - 2001 University of Tokyo Graduate School of Medicine Internal Medicine
  • 1985 - 1991 University of Tokyo Department of Medicine Faculty of Medicine
Professional career (1)：
  • 医学博士 (東京大学)
Work history (10)：
  • 2022/04 - 現在 Teikyo University Faculty of Medical Technology Professor
  • 2003/04 - 現在 Massachusetts General Hospital Endocrine Unit
  • 2018/10 - 2022/03 Teikyo University School of Medicine Department of Biochemistry
  • 2001/04 - 2007/05 宮内庁病院 内科
  • 1998/04 - 2003/03 東京都臨床医学総合研究所分子腫瘍研究部
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Awards (4)：
  • 2023/04 - 内藤記念科学振興財団 内藤記念科学奨励 副甲状腺ホルモン受容体の下流で骨及び軟骨の分化を制御する細胞内シグナル経路の解明
  • 2021/10 - 帝京大学医学部 ベストティーチャー アワード
  • 2021/04 - テルモ生命科学振興財団 2021年度研究開発助成 Salt Inducible Kinase (Sik)による骨・軟骨分化制御機構の解明
  • 2013/06 - 国際骨代謝学会 トラベルアワード
Association Membership(s) (3)：
THE JAPANESE SOCIETY OF INTERNAL MEDICINE ,  JAPANESE ASSOCIATION FOR ACUTE MEDICINE ,  AMERICAN SOCIETY FOR BONE AND MINERAL RESEARCH
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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