Rchr
J-GLOBAL ID:201901010912517200   Update date: Jul. 27, 2021

Nishimori Shigeki

ニシモリ シゲキ | Nishimori Shigeki
Affiliation and department:
Other affiliations (1):
  • Endocrine Unit, Massachusetts General Hospital
Research field  (1): Pathobiochemistry
Research keywords  (4): Bone Development ,  Chondrocyte Development ,  Parathyroid hormone related protein ,  Mouse Genetics
Research theme for competitive and other funds  (5):
  • 2020 - 2023 PTH/PTHrP/Sik経路による骨・軟骨細胞の分化制御メカニズム
  • 2020 - 2022 The roles of Salt Inducible Kinases (Sik) in endochondral bone formation
  • 2018 - 2020 PTH INVERSE AGONISTS AS THERAPY FOR JANSEN’S DISEASE
  • 1997 - 2020 PTH ACTIONS ON EARLY CELLS OF THE OSTEOBLAST LINEAGE
  • 1999 - 2016 DEVELOPMENTAL REGULATION OF BONE MORPHOGENESIS
Papers (28):
  • Shigeki Nishimori, Marc N. Wein, Henry M. Kronenberg. PTHrP targets salt-inducible kinases, HDAC4 and HDAC5, to repress chondrocyte hypertrophy in the growth plate. Bone. 2021. 142. 115709-115709
  • Meng Xie, Pavel Gol'din, Anna Nele Herdina, Jordi Estefa, Ekaterina V Medvedeva, Lei Li, Phillip T Newton, Svetlana Kotova, Boris Shavkuta, Aditya Saxena, et al. Secondary ossification center induces and protects growth plate structure. eLife. 2020. 9
  • Nishimori S, O'Meara MJ, Castro C, Noda H, Cetinbas M, da Silva Martins J, Ayturk U, Brooks DJ, Bruce M, Nagata M, et al. Salt-inducible kinases dictate parathyroid hormone receptor action in bone development and remodeling. The Journal of clinical investigation. 2019. 129. 12. 5187-5203
  • Nishimori S, Lai F, Shiraishi M, Kobayashi T, Kozhemyakina E, Yao TP, Lassar AB, Kronenberg HM. PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy. JCI insight. 2019. 4. 5
  • Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, et al. Corrigendum: SIKs control osteocyte responses to parathyroid hormone. Nature communications. 2017. 8. 14745
more...
MISC (49):
  • Shigeki Nishimori, Marc N. Wein, Henry M. Kronenberg. Actions of PTHrP, HDAC4, and SIK3 to Regulate Chondrocyte Hypertrophy. JOURNAL OF BONE AND MINERAL RESEARCH. 2017. 32. S68-S68
  • Garyfallia Papaioannou, Fatemeh Mirzamohammadi, Shigeki Nishimori, Marc Wein, Henry Kronenberg, Eric N. Olson, Tatsuya Kobayashi. MicroRNA-140 provides robustness to the regulation of hypertrophic chondrocyte differentiation by the PTHrP-HDAC4 pathway. JOURNAL OF BONE AND MINERAL RESEARCH. 2014. 29. S40-S40
  • Shigeki Nishimori, Forest Lai, Marc Wein, Elena Kozhemyakina, Eric Olson, Andrew Lassar, Henry Kronenberg. Complete Suppression of PTHrP Signaling in Chondrocytes in the Histone Deacetylase 4 and 5 Double Knockout Mouse. JOURNAL OF BONE AND MINERAL RESEARCH. 2013. 28
  • 西森茂樹, 三宅康史. 重症患者の全身管理. 月刊レジデント. 2009. 2. 10. 110-117
  • K. L. Conen, S. Nishimori, S. Provot, H. M. Kronenberg. Overexpression of the Transcriptional Cofactor Lbh Impaires Angiogenesis and Endochondral Bone Formation During Fetal Bone Development in Chickens. JOURNAL OF BONE AND MINERAL RESEARCH. 2008. 23. S244-S244
more...
Books (35):
  • 治療薬UP-TO-DATE 2021
    メディカルレビュー社 2021 ISBN:9784779225086
  • 治療薬UP-TO-DATE 2020
    メディカルレビュー社 2020 ISBN:4896004582
  • 治療薬UP-TO-DATE 2019
    メデイカルレビュー社 2019 ISBN:9784779220654
  • 治療薬UP-TO-DATE 2018
    メデイカルレビュー社 2018 ISBN:9784779219788
  • 治療薬UP-TO-DATE 2017
    メデイカルレビュー社 2017 ISBN:9784779217920
more...
Lectures and oral presentations  (18):
  • PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy
    (Metabolic Bone Disease Meeting 2019 in Seoul 2019)
  • Continuous infusion of PTHrP(7-36) Inverse Agonist Ameliorates the Delay in Endochondral Bone Formation in a Mouse Model of Jansen’s Metaphyseal Chondrodysplasia
    (The American Society for Bone and Mineral Research, Montreal 2018)
  • PTHrP Targets Salt-induced Kinases to Regulate Chondrocyte Differentiation
    (The American Society for Bone and Mineral Research, Montreal 2018)
  • Roles of PTHrP, HDAC4, and Salt-inducible Kinase 3 (Sik3) to Regulate Chondrocyte Hypertrophy
    (American Academy of Orthopaedic Surgeons, Chicago 2018)
  • Actions of PTHrP, HDAC4, and SIK3 to Regulate Chondrocyte Hypertrophy
    (The American Society for Bone and Mineral Research, Denver 2017)
more...
Education (2):
  • 1997 - 2001 University of Tokyo Internal Medicine
  • 1985 - 1991 University of Tokyo Faculty of Medicine
Professional career (1):
  • 医学博士 (東京大学)
Work history (7):
  • 2018/10 - 現在 Teikyo University School of Medicine Department of Biochemistry
  • 2003/04 - 現在 Massachusetts General Hospital Endocrine Unit
  • 1996/06 - 2003/03 University of Tokyo, Department of Medicine Fourth Department of Internal Medicine
  • 1994/02 - 1996/05 Showa General Hospital Department of Emergency Medicine
  • 1993/04 - 1994/01 Toranomon Hospital Nephrology Center
Show all
Association Membership(s) (3):
THE JAPANESE SOCIETY OF INTERNAL MEDICINE ,  JAPANESE ASSOCIATION FOR ACUTE MEDICINE ,  AMERICAN SOCIETY FOR BONE AND MINERAL RESEARCH
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