Rchr
J-GLOBAL ID：201901011405644433   Update date: Apr. 11, 2024

Tsunaka Yasuo

ツナカ ヤスオ | Tsunaka Yasuo
Affiliation and department：
Osaka University Department of Biotechnology, Graduate School of Engineering

About Osaka University Department of Biotechnology, Graduate School of Engineering


Job title： Specially Designated Lecturer
Research field  (5)： Applied biochemistry ,  Pharmaceuticals - analytical and physicochemistry ,  Functional biochemistry ,  Molecular biology ,  Structural biochemistry
Research keywords  (17)： Purification of virus vector ,  Purification of protein complexes ,  Column Chromatography ,  Viral Vector manufacturing for gene therapy ,  FACT ,  Synergistic structural biology ,  NMR ,  Cryo-electron microscopy ,  Intrinsically disordered protein ,  X-ray crystal structure analysis ,  Histone ,  Chromatin ,  Structural Biology ,  Epigenetics ,  Nucleosome ,  Histone chaperone ,  Chromatin remodeling
Research theme for competitive and other funds  (6)：
  • 2021 - 2025 Structural basis for histone discrimination mechanism by FACT
  • 2018 - 2023 Structural basis for nucleosome reconstitution mechanism by FACT
  • 2014 - 2017 Molecular mechanism of chromatin remodeling coupled with DNA transaction
  • 2011 - 2015 FACTを介したクロマチンリモデリング機構の構造基盤
  • 2011 - 2014 Structural Basis for the chromatin remodeling by nuclear receptors
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Papers (31)：
  • Tomohiko Ikeda, Yuki Yamaguchi, Hiroaki Oyama, Aoba Matsushita, Yasuo Tsunaka, Mitsuko Fukuhara, Tetsuo Torisu, Susumu Uchiyama. Higher-Order Structure of Adeno-Associated Virus Serotype 8 by Hydrogen/Deuterium Exchange Mass Spectrometry. Viruses. 2024. 16. 4. 585
  • Haruka Nishiumi, Kiichi Hirohata, Mitsuko Fukuhara, Aoba Matsushita, Yasuo Tsunaka, Mark Allen Vergara Rocafort, Takahiro Maruno, Tetsuo Torisu, Susumu Uchiyama. Combined 100 keV cryo-electron microscopy and image analysis methods to characterize the wider adeno-associated viral products. Journal of pharmaceutical sciences. 2024
  • Hideaki Ohtomo, Tsutomu Yamane, Takashi Oda, Noriyuki Kodera, Jun-Ichi Kurita, Yasuo Tsunaka, Romain Amyot, Mitsunori Ikeguchi, Yoshifumi Nishimura. Dynamic Solution Structures of Whole Human NAP1 Dimer Bound to One and Two Histone H2A-H2B Heterodimers Obtained by Integrative Methods. Journal of Molecular Biology. 2023. 435. 15. 168189-168189
  • Hideaki Ohtomo, Shinsuke Ito, Nicholas J. McKenzie, Michael Uckelmann, Masatoshi Wakamori, Haruhiko Ehara, Ayako Furukawa, Yasuo Tsunaka, Marika Shibata, Shun-ichi Sekine, et al. H2A ubiquitination alters H3-tail dynamics on linker-DNA to enhance H3K27 methylation. Journal of Molecular Biology. 2023. 435. 4. 167936-167936
  • Masahiko Okuda, Yasuo Tsunaka, Yoshifumi Nishimura. Dynamic structures of intrinsically disordered proteins related to the general transcription factor TFIIH, nucleosomes, and histone chaperones. Biophysical Reviews. 2022. 14. 6. 1449-1472
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MISC (39)：
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Lectures and oral presentations  (14)：
  • クライオ電顕構造とNMR解析を組み合わせてFACTを介したヒストンテイルの動的構造変化にせまる
    (第39回染色体ワークショップ・ 第20回核ダイナミクス研究会 2021)
  • Structural characterization for dynamic changes of histone H2A and H2B tails by FACT
    (The 44th Annual Meeting of the Molecular Biology Society of Japan 2021)
  • FACT acts as a modulator for dynamic behavior of nucleosome, thereby altering the accessibility.
    (The 94th Annual Meeting of the Japanese Biochemical Society 2021)
  • Structural characterization of dynamic changes of histone H3 N-tails through FACT using synergistic structural biology approaches
    (2021)
  • Dynamic behavior of histone H3 N-tails in chromatin remodeling by FACT
    (The 14th Annual Meeting of the Japanese Society for Epigenetics 2021)
ｍore...
Education (3)：
  • 2001 - 2004 Osaka University Graduate School of Engineering
  • 1999 - 2001 Osaka University Graduate School of Engineering
  • 1995 - 1999 Osaka University School of Engineering
Professional career (1)：
  • Ph.D. (Osaka University)
Work history (6)：
  • 2022/09 - 現在 Osaka University Graduate School of Engineering
  • 2017/04 - 2022/08 Yokohama City University Graduate School of Medical Life Science
  • 2011/04 - 2017/03 Kyoto University
  • 2006/10 - 2011/03 Osaka University Institute for Protein Research
  • 2005/10 - 2006/09 National Institute of Genetics
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Awards (1)：
  • 2016/12 - The 39th annual meeting of the Molecular Biology Society of Japan Excellent poster award Molecular mechanism for chromatin remodeling by FACT
Association Membership(s) (4)：
PROTEIN SCIENCE SOCIETY OF JAPAN ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE JAPANESE BIOCHEMICAL SOCIETY ,  The Japanese Society for Epigenetics
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