Koya Yoshihiro

コヤヨシヒロ | Koya Yoshihiro

Affiliation and department：
Job title：特任講師

Research field (4)： Virology , Immunology , Obstetrics and gynecology , Tumor biology

Research keywords (4)：ウイルス学 , Tumor immunology , Gynecologic oncology , Oncology

Research theme for competitive and other funds (7)：

2024 - 2027 Identification and functional analysis of ovarian cancer-associated neutrophils and their investigation as novel therapeutic targets
2023 - 2026 卵巣癌腹膜微小環境を突破する新規CAR-T細胞療法の確立
2021 - 2025 腹水中ペプチド・デグラドミクスに注目した進行卵巣癌に対する腹腔内環境戦略の創生
2021 - 2024 Analysis of the mechanism of anti-tumor immunosuppression by peritoneal mesothelial cells phagocytosed with ovarian cancer cells and investigation of the method for reactivation anti-tumor immunity
2016 - 2019 Development of new strategic oncolytic virotherapy for advanced ovarian cancer

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Papers (37)：

Hiroki Fujimoto, Masato Yoshihara, Raymond Rodgers, Shohei Iyoshi, Kazumasa Mogi, Emiri Miyamoto, Sae Hayakawa, Maia Hayashi, Satoshi Nomura, Kazuhisa Kitami, et al. Tumor-associated fibrosis: a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination. Cancer metastasis reviews. 2024
Kaname Uno, Yoshihiro Koya, Masato Yoshihara, Shohei Iyoshi, Kazuhisa Kitami, Mai Sugiyama, Emiri Miyamoto, Kazumasa Mogi, Hiroki Fujimoto, Yoshihiko Yamakita, et al. Chondroitin Sulfate Proteoglycan 4 Provides New Treatment Approach to Preventing Peritoneal Dissemination in Ovarian Cancer. International journal of molecular sciences. 2024. 25. 3
Kazumasa Mogi, Yoshihiro Koya, Masato Yoshihara, Mai Sugiyama, Rika Miki, Emiri Miyamoto, Hiroki Fujimoto, Kazuhisa Kitami, Shohei Iyoshi, Sho Tano, et al. 9-oxo-ODAs suppresses the proliferation of human cervical cancer cells through the inhibition of CDKs and HPV oncoproteins. Scientific reports. 2023. 13. 1. 19208-19208
Akira Yokoi, Mayu Ukai, Takao Yasui, Yasuhide Inokuma, Kim Hyeon-Deuk, Juntaro Matsuzaki, Kosuke Yoshida, Masami Kitagawa, Kunanon Chattrairat, Mikiko Iida, et al. Identifying high-grade serous ovarian carcinoma-specific extracellular vesicles by polyketone-coated nanowires. Science advances. 2023. 9. 27. eade6958
Xinxin Lin, Nobuhisa Yoshikawa, Wenting Liu, Tetsuya Matsukawa, Kae Nakamura, Masato Yoshihara, Yoshihiro Koya, Mai Sugiyama, Satoshi Tamauchi, Yoshiki Ikeda, et al. DDIT4 Facilitates Lymph Node Metastasis via the Activation of NF-κB Pathway and Epithelial-Mesenchymal Transition. Reproductive sciences (Thousand Oaks, Calif.). 2023

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MISC (144)：

Iyoshi Shohei, Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Yamakita Yoshihiko, Kitami Kazuhisa, Miyamoto Emiri, Fujimoto Hiroki, Uno Kaname, Mogi Kazumasa, et al. 卵巣癌腹膜転移における脂肪組織の標的脂肪細胞脱分化の腫瘍促進的役割と悪性腹水による脱分化過程阻害剤スクリーニングのための新規脂質滴蛍光センサーの開発(Targeting adipose tissue in ovarian cancer peritoneal metastasis; A tumor promoting role of adipocyte dedifferentiation and the development of a novel lipid droplet fluorescent sensor for inhibitor screening of dedifferentiation process caused by malignant ascites). 日本産科婦人科学会雑誌. 2024. 76. 臨増. S-238
Uno Kaname, Yoshihara Masato, Yamakita Yoshihiko, Miyamoto Emiri, Fujimoto Hiroki, Iyoshi Shohei, Mogi Kazumasa, Sugiyama Mai, Koya Yoshihiro, Yoshikawa Nobuhisa, et al. 白金製剤の分布による白金製剤耐性卵巣癌の新たな定義(New definition of platinum resistant ovarian cancer through platinum distribution). 日本産科婦人科学会雑誌. 2024. 76. 臨増. S-238
Miyamoto Emiri, Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Yamakita Yoshihiko, Fujimoto Hiroki, Iyoshi Shohei, Mogi Kazumasa, Uno Kaname, Kitami Kazuhisa, et al. メフリン陽性癌関連線維芽細胞は腹膜播種抑制制御を介して進行卵巣癌に抗腫瘍効果を示す(Oncology-Basic Research 2 Meflin-positive cancer-associated fibroblasts exhibit antitumor effect in advanced ovarian cancer through regulation of inhibition of peritoneal dissemination). 日本産科婦人科学会雑誌. 2024. 76. 臨増. S-257
Yoshihara Masato, Fujimoto Hiroki, Iyoshi Shohei, Miyamoto Emiri, Mogi Kazumasa, Uno Kaname, Kitami Kazuhisa, Sugiyama Mai, Koya Yoshihiro, Nawa Akihiro, et al. 難治性卵巣癌の腹膜進展に対する潜在的治療標的としての癌関連線維症(Cancer-associated fibrosis as a potential therapeutic target for peritoneal progression of refractory ovarian cancer). 日本産科婦人科学会雑誌. 2024. 76. 臨増. S-267
Mogi Kazumasa, Yoshihara Masato, Miyamoto Emiri, Fujimoto Hiroki, Uno Kaname, Iyoshi Shohei, Sugiyama Mai, Koya Yoshihiro, Yamakita Yoshihiko, Nawa Akihiro, et al. 腫瘍内血管の供給源としてのがん関連中皮細胞は卵巣がんの潜在的治療標的である(Cancer-associated mesothelial cells as a source of intratumoral vessels are potential therapeutic targets for ovarian cancer). 日本産科婦人科学会雑誌. 2024. 76. 臨増. S-349

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Lectures and oral presentations (48)：

難治性婦人科がんの克服を目指して腫瘍促進的腹膜環境の正常化を標的とした難治性卵巣癌に対する新規治療戦略の開発
(日本婦人科腫瘍学会学術講演会プログラム・抄録集 2022)
コンディショナルノックインマウスを用いた卵巣がん関連中皮細胞の系譜追跡と機能解析
(日本婦人科腫瘍学会学術講演会プログラム・抄録集 2022)
脂肪-中皮細胞により制御される卵巣がん微小環境と腹膜播種
(日本癌学会総会記事 2021)
ビタミンDによる卵巣癌腹膜播種を亢進する腹膜中皮細胞のEMTを標的とした治療
(日本癌学会総会記事 2021)
卵巣癌腹膜播種においてNotchシグナルは代謝変容を通して薬剤抵抗性獲得に寄与する
(日本癌学会総会記事 2021)

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