Nagasawa Shota

Affiliation and department：

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (1)：有機合成化学

Research theme for competitive and other funds (5)：

2022 - 2025 有機ニトロキシルラジカルー遷移金属協奏触媒の機能創成を機軸とする精密有機分子構築
2021 - 2023 遷移金属触媒的C-H官能基化を基盤とするキュバン修飾法の開発とその医薬化学的応用
2019 - 2021 Radical-initiated C-H functionalization of cubane for medicinal chemistry
2017 - 2018 抗腫瘍活性天然物 Taxagifine およびその誘導体の合成研究
2014 - 2017 アザアダマンタン型オキソアンモニウム塩を触媒とするオレフィン類空気酸化反応の開発

Papers (20)：

Hiroyuki Yamakoshi, Michihiro Fukuda, Hiro Ikeda, Shogo Fujiki, Aki Kohyama, Shota Nagasawa, Hanae Shinozaki, Hiroyuki Shibata, Yoshiharu Iwabuchi. Design, Synthesis, and Biological Evaluation of Water-Soluble Prodrugs of C5-Curcuminoid GO-Y030 Based on Reversible Thia-Michael Reaction. Chemical and Pharmaceutical Bulletin. 2024. 72. 1. 127-134
Yuki Tateishi, Ryo Sato, Shingo Komatsu, Masatsugu Noguchi, Shota Nagasawa, Yusuke Sasano, Naoki Kanoh, Yoshiharu Iwabuchi. Asymmetric Total Synthesis of Cytotrienin A: Late-stage Installation of C11 Side Chain onto the Macrolactam Scaffold. Angewandte Chemie (International ed. in English). 2023. e202303140
Shogo Fujiki, Takumi Takada, Shota Nagasawa, Hiroshi Okada, Yusuke Sasano, Eunsang Kwon, Yutaka Matsuo, Yoshiharu Iwabuchi. Sequential click modification of a lithium-ion endohedral fullerene connecting small molecules through a dieneazide linker. CHEMICAL COMMUNICATIONS. 2023. 59. 9. 1237-1240
Daigo Ninomiya, Shota Nagasawa, Yoshiharu Iwabuchi. Enantiocontrolled Access to an Intermediate for Highly Functionalized Clovane-Type Terpenoids: Formal Synthesis of Rumphellclovane E. ORGANIC LETTERS. 2022. 24. 41. 7572-7576
Naoki Kanoh, Yuta Terajima, Suguru Tanaka, Ryusei Terashima, Hiromichi Nishiyama, Shota Nagasawa, Yusuke Sasano, Yoshiharu Iwabuchi, Shinichi Nishimura, Hideaki Kakeya. Toward the Creation of Induced Pluripotent Small (iPS) Molecules: Establishment of a Modular Synthetic Strategy for the Heronamide C-type Polyene Macrolactams and Their Conformational and Reactivity Analysis. The Journal of Organic Chemistry. 2021. 86. 23. 16231-16248

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MISC (9)：

西嶋政樹, 長澤翔太, 笹野裕介, 荒木保幸, 岩渕好治, 和田健彦. Photosensitized Singlet Oxygen-supported Alcohol Oxidation Mediated by Nitroxyl Radical Catalyst. 日本化学会春季年会講演予稿集(Web). 2023. 103rd
Shota Nagasawa, Yusuke Sasano, Yoshiharu Iwabuchi. THE UTILITY OF OXOAMMONIUM SPECIES IN ORGANIC SYNTHESIS: BEYOND ALCOHOL OXIDATION. Heterocycles. 2022. 105. 1. 61-114
叶直樹, 叶直樹, 寺嶋優太, 田中卓, 寺島隆世, 西山大陸, 長澤翔太, 笹野裕介, 岩渕好治. Studies directed toward the creation of induced pluripotent small (iPS) molecules based on naturally occurring polyene macrolactams. 複素環化学討論会講演要旨集. 2021. 50th
建石悠貴, 佐藤亮, 小松慎吾, 野口正嗣, 長澤翔太, 笹野裕介, 叶直樹, 岩渕好治. アンサマクロラクタム抗腫瘍活性天然物Cytotrienin Aの合成研究. 創薬懇話会講演要旨集. 2021. 2021
西山大陸, 寺島隆世, 長澤翔太, 岩渕好治, 叶直樹. Studies aimed at the synthesis and mode of action of heronamide C analogues. 日本薬学会年会要旨集(Web). 2021. 141st

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Education (1)：

2012 - 2017 Tohoku University Graduate School of Pharmaceutical Sciences Division of Molecular Pharmaceutical Chemistry

Professional career (1)：

Ph.D (Pharm. Sci.) (Tohoku University)

Work history (4)：

2019/04 - 現在 Tohoku University Graduate School of Pharmaceutical Sciences
2017/06 - 2019/03 University of California, Berkeley
2017/04 - 2017/05 Tohoku University Graduate School of Pharmaceutical Sciences
2014/04 - 2017/03 日本学術振興会特別研究員(DC1)

Association Membership(s) (3)：

THE JAPANESE SOCIETY FOR PROCESS CHEMISTRY , THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN , THE PHARMACEUTICAL SOCIETY OF JAPAN

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