Rchr
J-GLOBAL ID：201901013571609320
Update date: Sep. 18, 2024
Nishimune Hiroshi
ニシムネ ヒロシ | Nishimune Hiroshi
Affiliation and department：
Job title：
Research Director
Homepage URL (2)：
https://www.tmghig.jp/research/team/roukanou-shinkeikagaku/roukashinkei/
,
https://www.tmig.or.jp/eresearch/a34.html
Research field (4)：
Neuroscience - general
, Neuroanatomy and physiology
, Neuropathology
, Rehabilitation science
Research keywords (10)：
Neuroscience
, Neuromuscular junction
, Synapse
, Active Zone
, Mitochondria
, Aging
, Amyotrophic lateral sclerosis
, ALS
, Mesenchymal stem cell
, Super Resolution Microscopy
Research theme for competitive and other funds (19)：
- 2024 - 2027 Research into the mechanism of action of materials that inhibit aging-related degeneration of the neuromuscular junction
- 2024 - 2027 Denervation mechanism and intervention methods of the ALS neuromuscular junction
- 2020 - 2025 Effects of autonomic nervous activation during swallowing on skeletal muscle and its application to the prevention of sarcopenia
- 2021 - 2024 Research on food ingredients that suppress aging-related degeneration of the neuromuscular junction
- 2020 - 2023 Investigation of mechanisms how synapse organizer and mesenchymal stem cells ameliorate ALS neurodegeneration.
- 2017 - 2022 Center for Biomedical Research Excellence (COBRE) Phase 3: Molecular Regulation of Cell Development and Differentiation
- 2019 - 2020 Super resolution microscope for the imaging core facility
- 2018 - 2020 Human mesenchymal stem cells ameliorate symptoms of als model mice
- 2015 - 2020 Exercise-activated mechanisms reduce degeneration of aged neuromuscular junctions
- 2018 - 2019 Neuronal Deficits in a Mouse Model of Autism and Autosomal Dominant SPECC1L Mutation Syndrome
- 2012 - 2018 Active zone loss cause dying back neuropathy in amyotrophic lateral sclerosis
- 2016 - 2017 Effect of oxaloacetate for the lifespan of ALS model mice
- 2010 - 2015 Synaptic formation by presynaptic calcium channels
- 2007 - 2010 Organization of the nerve terminal by synaptic cleft components
- 2006 - 2009 Voltage gated calcium channel as a scaffolding protein for synapse formation
- 2007 - 2009 Synaptic differentiation organized by presynaptic calcium channels
- 2006 - 2007 Kansas IDeA Network of Biomedical Research Excellence
- Exercise-regulated genes ameliorate NMJ denervation in aging
- Neuronal Deficits in a Mouse Model of Autosomal Dominant SPECC1L Mutation Syndrome
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Papers (47)：
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Omar Jawdat, Jason Rucker, Tomoki Nakano, Kotaro Takeno, Jeffery Statland, Mamatha Pasnoor, Mazen M Dimachkie, Carla Sabus, Yomna Badawi, Suzanne L Hunt, et al. Resistance exercise in early-stage ALS patients, ALSFRS-R, Sickness Impact Profile ALS-19, and muscle transcriptome: a pilot study. Scientific reports. 2024. 14. 1. 21729-21729
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Kotaro Takeno, Nobuhiro Watanabe, Masashi Morifuji, Harumi Hotta, Hiroshi Nishimune. Identification of adrenergic presynaptic and postsynaptic protein locations at neuromuscular junctions, their decrease during aging, and recovery by nicotinamide mononucleotide administration. Neuroreport. 2024. 35. 12. 805-812
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Ritsuko Inoue, Hiroshi Nishimune. Neuronal Plasticity and Age-Related Functional Decline in the Motor Cortex. Cells. 2023. 12. 17
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Ritsuko Inoue, Masami Miura, Shuichi Yanai, Hiroshi Nishimune. Coenzyme Q10 supplementation improves the motor function of middle-aged mice by restoring the neuronal activity of the motor cortex. Scientific reports. 2023. 13. 1. 4323-4323
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Kenji Takikawa, Hiroshi Nishimune. Similarity and Diversity of Presynaptic Molecules at Neuromuscular Junctions and Central Synapses. Biomolecules. 2022. 12. 2
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MISC (6)：
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H. Nishimune, S. Mori, Y. Badawi, K. Shigemoto. SUPER RESOLUTION MICROSCOPY ANALYSIS OF NMJ ACTIVE ZONES IN ADULT AND AGED MICE. MUSCLE & NERVE. 2015. 52. S137-S137
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Hiroshi Nishimune, John Stanford, Sudheer Tungtur, Kimberly Stanford. RESISTANCE EXERCISE AMELIORATES NEUROMUSCULAR JUNCTION DENERVATION IN AGING BY INCREASING THE ACTIVE ZONE ORGANIZERS. MUSCLE & NERVE. 2015. 52. S31-S31
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Takafumi Mizushige, Katsuya Okawa, Hiroshi Nishimune. Voltage-gated calcium channels [VGCC] interact with cell surface ATP synthase to induce presynaptic differentiation in the brain. NEUROSCIENCE RESEARCH. 2009. 65. S78-S79
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Hiroshi Nishimune, Jeff H. Miner, Joshua R. Sanes. A role for laminin in postsynaptic differentiation at the neuromuscular junction. NEUROSCIENCE RESEARCH. 2007. 58. S43-S43
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UYEDA Atsuko, FUKUI Iwao, Mony Simo Wydiastuti, FUJIMORI Kazuhiro, NISHIMUNE Hiroshi, KIYOSUE Kazuyuki, KASAI Michiki, TAGUCHI Takahisa. Characterization of novel proteins which promote neurite-outgrowth. 1998. 21. 645-645
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Education (2)：
- 1991 - 1995 Osaka University Graduate School of Engineering Science Department of Biophysical Engineering
- 1987 - 1991 Osaka University School of Engineering Science Department of Biophysical Engineering
Professional career (1)：
Work history (9)：
- 2020/04 - 現在 Tokyo Metropolitan Institute of Gerontology Neurobiology of Aging Theme Leader
- 2019/07 - 2020/03 University of Kansas School of Medicine Department of Anatomy and Cell Biology Professor
- 2013/07 - 2019/06 University of Kansas School of Medicine Department of Anatomy and Cell Biology Associate Professor
- 2006/09 - 2013/06 University of Kansas School of Medicine Department of Anatomy and Cell Biology Assistant Professor
- 2004/07 - 2006/08 Harvard University Dept. of Molecular and Cellular Biology Dr. Joshua R Sanes’ lab Postdoctoral fellow
- 2000/07 - 2004/06 Washington University School of Medicine Dr. Joshua R Sanes’ lab Postdoctoral fellow
- 2000/02 - 2000/06 INSERM U. 382, Developmental Biology Institute of Marseille Dr. Christopher E Henderson’s lab Novartis Foundation Japan-Europe Science Exchange Program Fellow
- 1998/02 - 2000/01 INSERM U. 382, Developmental Biology Institute of Marseille Dr. Christopher E Henderson’s lab Japan Science and Technology Corporation Overseas Research Fellow
- 1995/09 - 1998/01 National Institute of Advanced Industrial Science and Technology, Ikeda, Japan Dr. Takahisa Taguchi's laboratory Japan Science and Technology Corporation National Institute Fellow
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