Ii Hiromi

Affiliation and department：
Homepage URL (1)： http://labo.kyoto-phu.ac.jp/oncology/

Research field (1)： Tumor biology

Research keywords (2)： cancer cell metabolism , cancer research

Research theme for competitive and other funds (5)：

Papers (39)：

Yumiko Saito, Keiko Taniguchi, Hiromi Ii, Mano Horinaka, Susumu Kageyama, Susumu Nakata, Osamu Ukimura, Toshiyuki Sakai. Identification of c-Met as a novel target of γ-glutamylcyclotransferase. Scientific reports. 2023. 13. 1. 11922-11922
Yukie Nohara, Keiko Taniguchi, Hiromi Ii, Shun Masuda, Hiroko Kawakami, Masakatsu Matsumoto, Yasunao Hattori, Susumu Kageyama, Toshiyuki Sakai, Susumu Nakata, et al. Development of an activity-based chemiluminogenic probe for γ-glutamylcyclotransferase. Organic & biomolecular chemistry. 2023. 21. 29. 5977-5984
Kaito Ohta, Hiromi Ii, Chiami Moyama, Shota Ando, Hisanori Nambu, Susumu Nakata, Naoto Kojima. Thiophene Carboxamide Analogs with Long Alkyl Chains Comprising Ethylene Glycol Units Inhibit Glioblastoma Cell Proliferation by Activating AMPK. Journal of Medicinal Chemistry. 2023. 66. 9. 6403-6413
Chiami Moyama, Mitsugu Fujita, Hitoshi Okamoto, Hiromi Ii, Susumu Nakata. Myb Repression Mediates Stat5b-knockdown-induced Apoptosis and Inhibits Proliferation of Glioblastoma Stem Cells. Cancer genomics & proteomics. 2023. 20. 2. 195-202
Hiromi Ii, Keiko Taniguchi, Taku Yoshiya, Yukie Nohara, Susumu Kageyama, Akihiro Kawauchi, Susumu Nakata. The γ-Glutamylcyclotransferase Inhibitor Pro-GA Induces an Antiproliferative Effect Through the Generation of Mitochondrial Reactive Oxygen Species. Anticancer research. 2022. 42. 9. 4311-4317

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MISC (93)：

大田海斗, 飯居宏美, 茂山千愛美, 安藤翔太, 岩崎宏樹, 南部寿則, 中田晋, 小島直人. N-トリエチレングリコール含有アルキル-3-カルボキサミドの合成と膠芽腫に対する抗腫瘍効果. 日本薬学会九州山口支部大会講演要旨集(CD-ROM). 2023. 40th
大田海斗, 飯居宏美, 茂山千愛美, 安藤翔太, 岩﨑宏樹, 南部寿則, 中田晋, 小島直人. N-トリエチレングリコール含有アルキル-3-チオフェンカルボキサミド誘導体の合成と膠芽腫に対する生物活性の評価. 第73回日本薬学会関西支部総会・大会. 2023
下防穂乃佳, 草木菜穂, 小島直人, 飯居宏美, 中田晋. 新規アセトゲニン誘導体による小細胞肺がんおよび大腸がん細胞の増殖抑制効果. 第73回日本薬学会関西支部総会・大会. 2023
櫻井夏奈, 森昌也, 野瀬梢, 藤田貢, 飯居宏美, 中田晋. GGCT阻害剤とxCT阻害剤の併用による膠芽腫幹細胞に対する相乗的な増殖抑制効果. 第73回日本薬学会関西支部総会・大会. 2023
嶋田絢子, 山本夏菜, 橋本彩花, 野瀬梢, 藤田貢, 飯居宏美, 中田晋. 膠芽腫幹細胞のGGCT発現制御機構に対するcJunの関与. 第73回日本薬学会関西支部総会・大会. 2023

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Patents (2)：

Lectures and oral presentations (5)：

γグルタミルシクロトランスフェラーゼ阻害剤pro-GAはMCF7担癌マウスにおいて抗腫瘍効果を示す
(日本薬学会年会要旨集 2022)
γ-グルタミルシクロトランスフェラーゼを標的とした新規抗がん剤開発
(第77回日本癌学会学術総会 2018)
A novel prodrug of γ-glutamylcyclotransferase inhibitor has anti-proliferative activity in vitro and anti-cancer activity in vivo
(20th international conference on medicinal chemistry & rational drugs 2018)
Development of a new anti-cancer drug that targets the novel cancer-related protein C7orf24
(The 3rd International Symposium of Training Plan for Oncology Professionals 2015)
C7orf24阻害による新規細胞死機構の検討
(第64回日本薬学会近畿支部総会・大会 2014)

Education (3)：

Professional career (1)：

Work history (2)：

2010/07 - 現在 Kyoto Pharmaceutical University Department of Clinical Oncology Assistant professor
2008/10 - 2010/03 University of Washington Department of Chemistry and Biochemistry Postdoctoral fellow

Awards (2)：

2015/02 - The 3rd International Symposium of Training Plan for Oncology Professionals Best Presentation Award Development of a new anti-cancer drug that targets the novel cancer-related protein C7orf24.
2007/10 - XVI International Symposium on Drug Affecting Lipid Metabolism Young Investigator Award Cytosolic phospholipase A2α promotes atherosclerotic lesions in mice

Association Membership(s) (2)：

THE JAPANESE CANCER ASSOCIATION , THE PHARMACEUTICAL SOCIETY OF JAPAN

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