Inoue Masaki

イノウエマサキ | Inoue Masaki

Affiliation and department：
Job title：助教

Research field (2)： Pharmaceuticals - health and biochemistry , Pharmaceuticals - chemistry and drug development

Research keywords (4)：バイオ医薬 , タンパク質工学 , 薬物送達 , サイトカイン

Research theme for competitive and other funds (6)：

2022 - 2025 2型TNF受容体を介する免疫制御機構の解明とがん免疫療法への応用
2021 - 2024 免疫難病治療の新規モダリティを目指したTNFR1シグナル選択的阻害薬の創製
2018 - 2021 Molecular design of immunocytokines for control of regulatory T cell function
2018 - 2021 Study of TNFR2-APP3 signaling pathway and and its immuno-suppressive function
2018 - 2019 2型TNF受容体の選択的クラスタリング作用に基づく制御性T細胞の新規増幅法

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Papers (31)：

Takashi Tadokoro, Harumi Tsuboi, Kota Nakamura, Tetsushi Hayakawa, Reo Ohmura, Izumi Kato, Masaki Inoue, Shin-Ichi Tsunoda, Sayaka Niizuma, Yukari Okada, et al. Thermostability and binding properties of single-chained Fv fragments derived from therapeutic antibodies. Protein science : a publication of the Protein Society. 2024. 33. 7. e5084
Masaki Inoue, Yuta Tsuji, Ayaka Kashiwada, Asahi Yokoyama, Akane Iwata, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda. An immunocytokine consisting of a TNFR2 agonist and TNFR2 scFv enhances the expansion of regulatory T cells through TNFR2 clustering. Biochemical and Biophysical Research Communications. 2024
Masaki Inoue, Yuta Tsuji, Reira Ueno, Daisuke Miyamoto, Keisuke Tanaka, Yuka Moriyasu, Saya Shibata, Mei Okuda, Daisuke Ando, Yasuhiro Abe, et al. Bivalent structure of a TNFR2-selective and agonistic TNF-α mutein Fc-fusion protein enhances the expansion activity of regulatory T cells. Scientific reports. 2023. 13. 1. 13762-13762
Masaki Inoue, Kanako Yamashita, Yuta Tsuji, Midori Miki, Shota Amano, Taichi Okumura, Koki Kuge, Takao Tone, Shota Enomoto, Chinatsu Yoshimine, et al. Characterization of a TNFR2-Selective Agonistic TNF-α Mutant and Its Derivatives as an Optimal Regulatory T Cell Expander. The Journal of Immunology. 2021. 206. 8. 1740-1751
Masaki Inoue, Yuta Tsuji, Chinatsu Yoshimine, Shota Enomoto, Yuki Morita, Natsuki Osaki, Masahiro Kunishige, Midori Miki, Shota Amano, Kanako Yamashita, et al. Structural optimization of a TNFR1-selective antagonistic TNFα mutant to create new-modality TNF-regulating biologics. The Journal of biological chemistry. 2020. 295. 28. 9379-9391

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MISC (5)：

Inoue Masaki, Tsunoda Shin-ichi. Development of TNFR1-selective antagonistic TNF-α mutant as new biologics for treatment of immunological disorders. 2021. 93. 3. 391-395
Inoue Masaki. The 36^th Annual Meeting of the Japan Society of Drug Delivery System. Drug Delivery System. 2020. 35. 5. 450-451
Inoue Masaki. Development of artificial cytokine-derivatives as new biologics for treatment of immunological disorders. Drug Delivery System. 2019. 34. 2. 134-135
Inoue Masaki. The 45<sup>th</sup> Controlled Release Society Annual Meeting & Exposition. Drug Delivery System. 2018. 33. 4. 352-353
井上雅己, 角田慎一. 難病の克服に向けた先端バイオ医薬創出. 化学工業. 2017. 68. 317-323

Education (1)：

- 2013 Hiroshima University

Professional career (1)：

博士(薬学) (広島大学)

Work history (4)：

2020/04 - 現在神戸学院大学薬学部助教
2016/07 - 2020/03 Kobe Gakuin University The Faculty of Pharmaceutical Sciences
2015/04 - 2016/06 医薬基盤・健康・栄養研究所バイオ創薬プロジェクト特任研究員
2008/05 - 2015/03 医薬基盤研究所バイオ創薬プロジェクト技術補助員

Association Membership(s) (4)：

日本蛋白質科学会 , THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM , THE JAPANESE BIOCHEMICAL SOCIETY , THE PHARMACEUTICAL SOCIETY OF JAPAN

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