Bun Aoyama

Affiliation and department：
Job title： Visiting Scholar
Other affiliations (2)：

Research field (4)： Anesthesiology , Anesthesiology , Clinical pharmacy , Anesthesiology

Research keywords (8)：術後せん妄 , ミクログリア , 脳内神経炎症 , 神経ステロイド , 慢性痛 , 高齢者 , 運動による疼痛緩和 , 院内急変時の応援要請番号統一化

Research theme for competitive and other funds (8)：

2023 - 2024 The effect of allopregnanolone based on DNA methylation of postoperative delirium in aged mice.
2021 - 2023 A novel therapeutic strategy for postoperative delirium using neurosteroids and elucidation of its mechanism of action
2021 - 2022 機能性不織布の臨床研究
2021 - 2022 神経ステロイド(Allopregnanolone)を用いた術後せん妄に対する新規治療戦略と分子生物学に基づく作用機序の解明
2020 - 2021 分子生物学に基づく神経ステロイド(Allopregnanolone)が術後せん妄の抑制に寄与する機構の解明- 高齢ラット開腹手術モデルでの検討 -

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Papers (23)：

Tsuyoshi Nishiguchi, Kyosuke Yamanishi, Nipun Gorantla, Akiyoshi Shimura, Tomoteru Seki, Takaya Ishii, Bun Aoyama, Johnny R Malicoa, Nathan James Phuong, Nicole Jade Dye, et al. LPS-induced delirium-like behavior and microglial activation in mice correlate with bispectral electroencephalography (BSEEG). J Gerontol A Biol Sci Med Sci. 2024
Nishiguchi T, Yamanishi K, Patel S, Malicoat JR, Phuong NJ, Seki T, Ishii T, Aoyama B, Shimura A, Gorantla N, et al. Discovery of novel protective agents for infection-related delirium through bispectral electroencephalography. Transl Psychiatry. 2024. 14. 1. 413
Akiyoshi Shimura, Tomoteru Seki, Tsuyoshi Nishiguchi, Kyosuke Yamanishi, Takaya Ishii, Bun Aoyama, Hieu Dinh Nguyen, Nipun Gorantla, Takeshi Inoue, Gen Shinozaki. A web-based delirium detection application using bispectral electroencephalography (BSEEG). General Hospital Psychiatry. 2024
Aoyama B, Yatabe T, Locatelli FM, Minami M, Suganuma N, Hore P, Whitaker D, Kawano T. Current status of variations in in-hospital cardiac arrest call numbers in Japan: a nationwide survey. Journal of Anesthesia. 2021
勝又祥文, 矢田部智昭, 北川博之, 青山文, 立岩浩規, 中越菜月, 横山正尚. 心肺停止に至った非閉塞性腸間膜虚血症に対してベッドサイドで壊死腸管切除術を施行し救命し得た一例. 日本集中治療医学会雑誌. 2020. 27. 6. 477-478

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Books (11)：

Anesthesiologists Contribute to the Strategies for Postoperative Delirium
2023
Strategies for Postoperative Delirium after thoracoscopic surgery
2023
日本臨床麻酔学会誌 Vol.42 No.5 2022 p510-518 開心術における術後認知機能障害について -予防と対策-
中塚秀輝・岡山大学医学部麻酔・蘇生学教室 2022
The Japanese Journal of Anesthesiology
2021 ISBN:9784771905382
周術期管理チームテキスト第 4 版
公益社団法人日本麻酔科学会 2021

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Lectures and oral presentations (20)：

Team-Based Strategies for Postoperative Delirium: Insights from Anesthesiology
(The 71st Annual Meeting of the Japanese Society of Anesthesiologists 2024)
Intraoperative and Postoperative Measures for Preventing Postoperative Cognitive Dysfunction and Delirium in Elderly Patients
(2023)
術後せん妄
(第34回日本臨床モニター学会総会 2023)
THE RESULT OF A SURVEY ON IN-HOSPITAL CARDIAC ARREST CALL NUMBERS IN JAPAN.
(World Congress of Intensive Care 2019, Melbourne, Australia)
Changes in brain allopregnanolone levels after abdominal surgery in rats-age-related differences pertaining to postoperative delirium
(The 1st Joint Scientific Congress of TSCCM, TSECCM and JSICM 2022)

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Education (2)：

Professional career (1)：

Work history (8)：

2023/09 - 現在 Stanford School of Medicine Department of Psychiatry and Behavioral Science School of Medicine Visiting Scholar
2022/09 - 現在高知大学医学部麻酔科学・集中治療医学講座客員講師
2022/09 - 現在独立行政法人国立病院機構高知病院麻酔科医長
2021/02 - 2022/08 Kochi Medical School Department of Anesthesiology and Intensive Care Medicine
2016/07 - 2021/01 Kochi Medical School Department of Anesthesiology and Intensive Care Medicine

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Committee career (1)：

Awards (8)：

2022/06 - The 69th Annual Meeting of the Japanese Society of Anesthesiologists Best Research & Presentation Award Therapeutic and preventive effects of allopregnanolone on postoperative delirium in aged rats and its novel action mechanism by gene expression analysis using mRNA microarray
2021/07 - The 25th Annual Meeting of Japanese Society for Neuroscience in Anesthesiology and Critical Care Best presentation award Effects of the allopregnanolone as a novel treatment for postoperative delirium in aged rats
2020/03 - 高知大学令和元年度高知大学研究顕彰制度大学院生研究奨励賞
2019/03 - 15th Japanese Society for Neuroscience in Anesthesiology and Critical Care Award Role of neurosteroid allopregnanolone on age-related differences in exercise-induced hypoalgesia in rats
2018/05 - 日本麻酔科学会第65回学術集会優秀演題賞術後せん妄様行動に及ぼす脳内神経炎症の影響 -ラット開腹手術モデルでの検討-

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Association Membership(s) (5)：

日本小児麻酔学会 , 日本神経麻酔集中治療学会 , 日本集中治療医学会 , 日本心臓血管麻酔学会 , 日本麻酔科学会

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