J-GLOBAL ID:201901013970177396   Update date: May. 28, 2020

Kawabata Shigeru

カワバタ シゲル | Kawabata Shigeru
Research field  (1): Tumor biology
Research keywords  (7): Pulmonary Disease and Neoplasms, ,  Surgical Pathology, ,  Cancer Biology (Tumorigenesis and Signal Transduction), ,  Translational Cancer Research, ,  Mouse models of Cancer, ,  Cancer Therapeutic Development and Anti-Cancer Drug Resistance, ,  Cancer Prevention Research
Research theme for competitive and other funds  (2):
  • 2019 - 2020 小細胞肺癌に対するmTOR阻害剤を用いた維持療法の臨床開発: 免疫チェックポイント機構に関連するバイオマーカー解析
  • 2010 - 2012 The Role of EGFR in Endolymphatic Sac Tumors (April 2010-March 2012)
Papers (32):
  • Komiya T, Memmott RM, Blumenthal GM, Bernstein W, Ballas MS, De Chowdhury R, Chun G, Peer CJ, Figg WD, Liewehr DJ, Steinberg SM, Giaccone G, Szabo E, Kawabata S, Tsurutani J, Rajan A, Dennis PA. A phase I/II study of pemetrexed with sirolimus in advanced, previously treated non-small cell lung cancer. Transl Lung Cancer Res. 2019. 8:. 247-257,
  • 川畑 茂, 南口 早智子, 片岡 竜貴, 馬越 洋宜, 羽賀 博典, 森吉 弘毅. 膵insulinomatosisの2例. 診断病理. 2018. 35:. 140-145,
  • Osoegawa A, Gills JJ, Kawabata S, Dennis PA. Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib. Oncotarget. 2017. 8:. 87044-87053,
  • Lastwika KJ, Wilson W, Li QK, Norris J, Xu H, Ghazarian SR, Kitagawa H, Kawabata S, Taube JM, Yao S, Liu LN, Gills JJ, Dennis PA. Control of PD-L1 Expression by Oncogenic Activation of the AKT-mTOR Pathway in Non-Small Cell Lung Cancer. Cancer Res. 2016. 76:. 227-238,
  • Kawabata S, Heredia A, Gills JJ, Redfield RR, Dennis PA, Bryant J. Impact of HIV on lung tumorigenesis in an animal model. AIDS. 2015. 29:. 633-635,
MISC (2):
  • Dennis PA, Blumenthal G, Ballas M, Gardner E, Kawabata S, LoPiccolo J, Helsabeck C, Root H, Figg WD, Bernstein W. A phase I study of nelfinavir, an FDA approved HIV protease inhibitor, in adults with refractory solid tumors. Journal of Clinical Oncology. 2009. 27:. 2583,
  • Kawabata S, Oka M, Fukuda M, Kinoshita A, Nagashima S, Nakamura Y, Nakano H, Soda H, Kohno S. Phase I Study of Gemcitabine (GEM) and Carboplatin (CBDCA) in Advanced Non-Small Cell Lung Cancer (NSCLC). Journal of Clinical Oncology. 2004. 22:. 7291,
Lectures and oral presentations  (7):
  • The cellular context-dependent consequences of Apc mutations on gene regulation and cellular behavior
    (The 106th Annual Meeting of the Japanese Society of Pathology 2017)
  • Rapamycin decreases expression of thymidylate synthase and enhances the response to pemetrexed in preclinical studies and a Phase I/II clinical study of subjects with non-small cell lung cancer
    (AACR Annual Meeting 2014, Minisymposium (San Diego, CA, USA); 2014)
  • Rapamycin prolongs overall survival and progression-free survival in a mouse model of lung cancer in never smokers resistant to erlotinib
    (AACR Annual Meeting 2011, Minisymposium (Orlando, FL, USA); 2011)
  • Tumor stage-specific role of mTOR in a mouse model of lung cancer in never smokers that is resistant to EGFR tyrosine kinase inhibitors
    (NCI Medical Oncology Branch Research Seminar, Seminar series (Bethesda, MD, USA); 2010)
  • Updated Lung Cancer Treatment
    (Omura Medical Association Respiratory Disease Lecture Series 2006)
Education (1):
  • 1990 - 1996 Nagasaki University School of Medicine School of Medical Sciences
Professional career (1):
  • M.D., Ph.D. (Nagasaki University)
Work history (10):
  • 2019 - 現在 Osaka Medical College Faculty of Medicine Assistant professor
  • 2017 - 2019 National Hospital Organization Kyoto Medical Center Pathologist
  • 2015 - 2017 Kyoto University Hospital Resident
  • 2012 - 2015 The Johns Hopkins University School of Medicine (Baltimore, USA) Research Fellow
  • 2011 - 2012 National Cancer Institute (Bethesda, USA) Research Fellow
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Awards (6):
  • 2014/07 - Johns Hopkins University (USA) JH Libraries Open Access Promotion Fund
  • 2014/04 - American Association for Cancer Research (AACR) Millennium Scholar-in-Training Award
  • 2013/12 - Johns Hopkins University (USA) The Ruth D. Vogel Professional Development Award
  • 2011/02 - National Institutes of Health (USA) The Visiting Fellow Award, NIH Visiting Program, Department of Health & Human Services Research in lung cell biology and Signal Transduction Research
  • 2009/02 - National Institutes of Health (USA) The Visiting Fellow Award, NIH Visiting Program, Department of Health & Human Services Research in lung cell biology and Signal Transduction Research
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Association Membership(s) (4):
Board Certification (No. 3488), The Japanese Society of Pathology ,  Board Certification, The Japanese Society of Clinical Cytology ,  Board Certification (No. 7729), The Japanese Society of Internal Medicine ,  Associate Member (No. 65152), The American Association for Cancer Research
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