Rchr
J-GLOBAL ID：201901014774258333   Update date: Dec. 13, 2023

Yamamoto Kenji

Yamamoto Kenji
Affiliation and department：
National Hospital Organization Minami Kyoto Hospital Department of Neurology / Department of Clinical Research

About National Hospital Organization Minami Kyoto Hospital Department of Neurology / Department of Clinical Research


Job title： Director
Research field  (2)： Neuroscience - general ,  Neurology
Research keywords  (10)： Alzheimer's disease ,  amyloid β ,  amyloid precursor protein ,  α-synuclein ,  oligomer ,  patch clump ,  dopamine ,  Parkinson's disease ,  calcium ,  neurodegeneration
Research theme for competitive and other funds  (4)：
  • 2020 - 2023 The analysis of aberrant machinery mediated by intraneural and extraneural alpha-synuclein oilgomers
  • 2014 - 2017 The neuronal dysfunction by alpha-synuclein oligomers in Parkinson's disease
  • 2011 - 2014 The analysis of abnormal neuronal excitability mediated by alpha-synuclein oligomer
  • 2007 - 2009 Relationship between neuronal death and inclusion body formation
Papers (47)：
  • Masayuki Tahara, Tomoko Oeda, Kazumasa Okada, Kazuhide Ochi, Hirofumi Maruyama, Hikoaki Fukaura, Kyoichi Nomura, Yuko Shimizu, Ichiro Nakashima, Tatsuro Misu, et al. Compassionate open-label use of rituximab following a randomised clinical trial against neuromyelitis optica (RIN-2 study): B cell monitoring-based administration. Multiple Sclerosis and Related Disorders. 2022. 60. 103730-103730
  • 山本 兼司, 山本 亮, 加藤 伸郎. アミロイドβとアミロイド前駆蛋白の協調によるBKチャンネル抑制様式. 日本生理学雑誌. 2022. 84. 1. 4-5
  • 田原 将行, 大江田 知子, 岡田 和将, 越智 一秀, 丸山 博文, 野村 恭一, 深浦 彦彰, 中島 一郎, 三須 建郎, 清水 優子, et al. 視神経脊髄炎の再発に対するリツキシマブの有用性検証試験の継続投与試験 RIN-2試験. 臨床神経学. 2021. 61. Suppl. S304-S304
  • Kenji Yamamoto. Complicity of α-synuclein oligomer and calcium dyshomeostasis in selective neuronal vulnerability in Lewy body disease. Archives of Pharmacal Research. 2021
  • Kenji Yamamoto, Ryo Yamamoto, Nobuo Kato. Amyloid β and Amyloid Precursor Protein Synergistically Suppress Large-Conductance Calcium-Activated Potassium Channel in Cortical Neurons. Frontiers in Aging Neuroscience. 2021. 13
ｍore...
MISC (50)：
  • Yamamoto Kenji, Kato Nobuo. APPおよびamyloid βオリゴマーによる神経細胞興奮性亢進に対するhomer1aを介した回復力(Homer1a-mediated resilience against neuronal hyperexcitability by APP and amyloid beta oligomer). 臨床神経学. 2018. 58. Suppl. S382-S382
  • 南健太, 山本佐弥香, 横山香保, 堤健雄, 山本兼司, 大江田知子, 澤田秀幸, 杉山博. Risk factor analysis for colonization with metallo-beta-lactamase-producing Enterobacteriaceae in long-term-care patients. 医学検査. 2018. 67. 5. 636-642(J-STAGE)-642
  • Ohara Hiroaki, Umemura Atsushi, Park Kwiyoung, Kohsaka Masayuki, Tomita Satoshi, Tahara Masayuki, Yamamoto Kenji, Oeda Tomoko, Sugiyama Hiroshi, Sawada Hideyuki. 抗myelin-associated glycoprotein/抗sulfated glucuronic paragloboside抗体を保有する多発ニューロパチーの一症例における血漿交換とシクロホスファミドの有益な効果(Beneficial effects of plasma exchange and cyclophosphamide in a case of polyneuropathy associated with anti-myelin-associated glycoprotein/anti-sulfated glucuronic paragloboside antibodies). Clinical and Experimental Neuroimmunology. 2017. 8. 4. 367-367
  • Sawada Hideyuki, Oeda Tomoko, Umemura Atsushi, Tomita Satoshi, Kohsaka Masayuki, Park Kwiyoung, Yamamoto Kenji, Sugiyama Hiroshi. Parkinson病におけるベースラインC反応性蛋白値と生命予後(Baseline C-reactive protein level and life prognosis in Parkinson disease). 臨床神経学. 2016. 56. Suppl. S350-S350
  • Yamamoto Kenji, Sawada Hideyuki. ニューロン内アルファ-シヌクレインオリゴマによるIP3受容体からの異常なカルシウム放出機構(The mechanism of aberrant calcium release from IP3 receptor by intraneural alpha-synuclein oligomers). 臨床神経学. 2016. 56. Suppl. S382-S382
ｍore...
Lectures and oral presentations  (175)：
  • パーキンソン病の睡眠障害に対するレボドパ・カルビドパ配合経腸用液療法の長期効果
    (国立病院総合医学会講演抄録集 2022)
  • 進行性核上性麻痺患者における臨床亜型の変化
    (国立病院総合医学会講演抄録集 2022)
  • パーキンソン病患者における嚥下機能障害の機序 嚥下造影検査による検討
    (国立病院総合医学会講演抄録集 2022)
  • パーキンソン病認知機能に対するドネペジルの疾患修飾効果 ランダム比較試験
    (国立病院総合医学会講演抄録集 2022)
  • Association between blood pressure fluctuations and visual hallucination in Lewy body disease
    (国立病院総合医学会講演抄録集 2022)
ｍore...
Education (1)：
  • 1997 - 2001 Graduate School of Medicine, Kyoto University, Department of Neurology/Integrative Brain Science,
Professional career (1)：
  • MD, PhD (Kyoto University)
Work history (6)：
  • 2023 - 現在 National Hospital Organization Miami Kyoto Hospital Department of Neurology / Department of Clinical Research Director of Clinical Research
  • 2016 - 2023 National Hospital Organization Utano National Hospital, Department of Neurology and Clinical Research Center, Consultant
  • 2009 - 2023 National Hospital Organization Utano National Hospital, Department of Neurology and Clinical Research Center, Laboratory Head of physiology
  • 2006 - 2016 National Hospital Organization Utano National Hospital, Department of Neurology and Clinical Research Center head physician
  • 2003 - 2005 Kyoto University Hospital Department of Neurology, medical stuff
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Association Membership(s) (5)：
Society for Neuroscience ,  THE PHYSIOLOGICAL SOCIETY OF JAPAN ,  THE JAPAN NEUROSCIENCE SOCIETY ,  THE JAPANESE SOCIETY OF INTERNAL MEDICINE ,  JAPANESE SOCIETY OF NEUROLOGY
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