Rchr
J-GLOBAL ID：201901015381011340   Update date: Apr. 02, 2024

Nishitsuji Kazuchika

ニシツジ カズチカ | Nishitsuji Kazuchika
Affiliation and department：
Wakayama Medical University Department of Biochemistry

About Wakayama Medical University Department of Biochemistry


Research field  (1)： Medical biochemistry
Research keywords  (12)： preeclampsia ,  胎盤形成 ,  p53 ,  卵巣癌 ,  糖鎖 ,  スルファターゼ ,  Alzheimer's disease ,  heparan sulfate ,  glycosaminoglycan ,  コンフォメーション病 ,  amyloidosis ,  amyloid
Research theme for competitive and other funds  (11)：
  • 2022 - 2025 p53アミロイドーシスとしてのp53遺伝子変異卵巣癌の病態メカニズムの解明
  • 2022 - 2025 Relationship between mitochondria-ER interaction in placental development
  • 2020 - 2023 アミロイドβを標的とした新たな側面からの胎盤形成不全の病態解明
  • 2020 - 2020 妊娠高血圧腎症胎盤における硫酸化糖鎖の病態機能解析
  • 2017 - 2019 Enzymatic remodeling of heparan sulfate: a therapeutic strategy for systemic amyloidoses
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Papers (77)：
  • Yoshiko Takeda-Uchimura, Midori Ikezaki, Tomoya O Akama, Yoshito Ihara, Fabrice Allain, Kazuchika Nishitsuji, Kenji Uchimura. GlcNAc6ST2/CHST4 Is Essential for the Synthesis of R-10G-Reactive Keratan Sulfate/Sulfated N-Acetyllactosamine Oligosaccharides in Mouse Pleural Mesothelium. Molecules (Basel, Switzerland). 2024. 29. 4
  • Hiroyuki Yamada, Rin Yamada, Yoshihiro Komohara, Remi Mito, Kazuchika Nishitsuji, Hiromu Yano, Yukio Fujiwara, Koei Ikeda, Makoto Suzuki. A Case of Aggressive Lung Squamous Cell Carcinoma With Aberrant Cytoplasmic p53 Aggregation. Cancer diagnosis & prognosis. 2024. 4. 2. 204-208
  • Norihiro Namba, Takashi Ohgita, Hiroko Tamagaki-Asahina, Kazuchika Nishitsuji, Toshinori Shimanouchi, Takeshi Sato, Hiroyuki Saito. Amyloidogenic 60-71 deletion/ValThr insertion mutation of apolipoprotein A-I generates a new aggregation-prone segment that promotes nucleation through entropic effects. Scientific Reports. 2023. 13. 1. 18514-18514
  • Yuki Takechi-Haraya, Takashi Ohgita, Akiko Usui, Kazuchika Nishitsuji, Kenji Uchimura, Yasuhiro Abe, Ryuji Kawano, Monika I. Konaklieva, Mart Reimund, Alan T. Remaley, et al. Structural flexibility of apolipoprotein E-derived arginine-rich peptides improves their cell penetration capability. Scientific reports. 2023. 13. 1. 19396-19396
  • Kazuchika Nishitsuji, Midori Ikezaki, Shino Manabe, Yoshito Ihara. Functions of Protein C-Mannosylation in Physiology and Pathology. Trends in Glycoscience and Glycotechnology. 2023. 35. 204. E23-E27
ｍore...
MISC (64)：
  • 井原義人, 井内陽子, 岩橋尚幸, 南方志帆, 南方志帆, 森乃絢, 池崎みどり, 西辻和親, 井箟一彦, 眞鍋史乃. Pathophysiological response of protein C-mannosylation in ovarian cancer. 日本糖質学会年会要旨集. 2023. 42nd
  • 西辻和親, 池崎みどり, 眞鍋史乃, 眞鍋史乃, 井原義人. Functions of Protein C-Mannosylation in Physiology and Pathology. Trends in Glycoscience and Glycotechnology (Web). 2023. 35. 204
  • 西辻和親, 池崎みどり, 内村健治, 内村健治, 岩橋尚幸, 西岡香穂, 藤原章雄, 菰原義弘, 井箟一彦, 井原義人. Sulfated glycosaminoglycan-mediated spreading of p53 amyloid and its contribution to cancer pathology. 日本糖質学会年会要旨集. 2022. 41st
  • 南方志帆, 井内陽子, 西辻和親, 眞鍋史乃, 眞鍋史乃, 井原義人. Investigating the cellular uptake mechanism of C-mannosyl tryptophan. 日本糖質学会年会要旨集. 2022. 41st
  • 池崎みどり, 西辻和親, 眞鍋史乃, 眞鍋史乃, 内村健治, 内村健治, 伊藤幸成, 伊藤幸成, 井原義人. C-Mannosylated peptide attenuates astrocyte-induced synaptogenesis in rat cortical neurons. 日本糖質学会年会要旨集. 2022. 41st
ｍore...
Patents (3)：
Books (1)：
  • アルツハイマー病発症メカニズムと新規診断法・創薬・治療開発
    (株)エヌ・ティー・エス 2018
Lectures and oral presentations  (2)：
  • Glycan-Mediated Prion-Like Behavior of Mutant p53 Aggregates and Their Possible Role in Cancer Pathogenesis
    (Glyco26 2023)
  • Glycosaminoglycans in protein aggregation diseases.
    (1st International Conference on the Glycobiology of Nervous System 2017)
Education (3)：
  • 2004 - 2008 Osaka City University Graduate School of Medicine
  • 2002 - 2004 京都大学大学院 薬学研究科
  • 1997 - 2001 Kyoto University Faculty of Pharmaceutical Sciences
Professional career (1)：
  • 医学博士
Work history (6)：
  • 2022/04 - 現在 Wakayama Medical University
  • 2018/06 - 2022/03 Wakayama Medical University
  • 2018/01 - 2018/05 徳島大学大学院医歯薬学研究部 疾患病理学 助教
  • 2013/01 - 2017/12 徳島大学大学院医歯薬学研究部 病態病理学 助教
  • 2008/06 - 2011/12 国立長寿医療研究センター研究所 アルツハイマー病研究部 博士研究員
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Association Membership(s) (8)：
日本癌学会 ,  日本糖質学会 ,  THE JAPANESE SOCIETY FOR NEUROCHEMISTRY ,  日本アミロイドーシス学会 ,  Society for Neuroscience ,  THE MEMBRANE SOCIETY OF JAPAN ,  THE JAPANESE SOCIETY OF PATHOLOGY ,  日本生化学会
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