Research theme for competitive and other funds (7):
2025 - 2029 薬剤性認知症回避を目指した抗コリン薬の新規リスク指標開発
2021 - 2025 Development of gummi formulation for improvement of adherence for pediatric patients
2021 - 2024 Preparation and clinical evaluation of foam formulations for the treatment of oral mucositis.
2017 - 2020 Evaluation of acceptability and palatability of orally disintegrating tablets
2017 - 2020 Development of the blood concentration measurement system and implementation of therapeutic drug monitoring (TDM) of a novel drug for treatment of pulmonary hypertension.
2014 - 2017 Development and validation of the cocktail study for the method in detection of drug-drug interactions
2009 - 2011 Effect of the intake of grapefruit juice on blood pressures in hypertensive patients treated with calcium channel blockers
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Papers (48):
Mizuki Shiho, Shimako Tanaka, Eriko Nakatani, Toshiki Kurosawa, Yoshiyuki Kubo, Yoshiharu Deguchi, Takashi Okura. Brain distribution and muscarinic receptor occupancy of an active metabolite of fesoterodine in rats. The Journal of Pharmacology and Experimental Therapeutics. 2024. 100058-100058
Motoyasu Miura, Seiki Kojima, Shimako Tanaka, Yasuharu Kashiwagura, Noriyuki Namiki, Shinya Uchida. Palatability evaluation of orally disintegrating tablets using a visual analog scale in clinical trials. International journal of clinical pharmacology and therapeutics. 2024. 62. 8. 353-362
Mizuki Shiho, Gaku Akashita, Eriko Nakatani, Shimako Tanaka, Shizuo Yamada, Takashi Okura. Predicting muscarinic receptor occupancy in human bladder mucosa from urinary concentrations of antimuscarinic agents for overactive bladder. Drug Metabolism and Pharmacokinetics. 2024. 100998
Eriko Nakatani, Masaki Sasai, Hidetoshi Miyazaki, Shimako Tanaka, Tatsuhiko Hirota, Takashi Okura. Investigating the Transepithelial Transport and Enzymatic Stability of Lactononadecapeptide (NIPPLTQTPVVVPPFLQPE), a 19-Amino Acid Casein-Derived Peptide in Caco-2 Cells. Journal of agricultural and food chemistry. 2024
Gaku Akashita, Eriko Nakatani, Shimako Tanaka, Takashi Okura. Development of simultaneous determination of dopamine 2, histamine 1, and muscarinic acetylcholine receptor occupancies by antipsychotics using liquid chromatography with tandem mass spectrometry. Journal of pharmacological and toxicological methods. 2024. 127. 107518-107518