Nishizawa Hironari

ニシザワヒロナリ | Nishizawa Hironari

Affiliation and department：
Job title：学術研究員

Research field (3)： Cell biology , Tumor biology , Molecular biology

Research keywords (5)： Ferroptosis , Clinical oncology of Lung cancer , Senescence and Aging , Transcription of genes , Cell death

Research theme for competitive and other funds (7)：

2023 - 2026 微小環境における、がん-線維芽細胞連関の悪循環による治療耐性化機構の解明
2020 - 2025 Development of anti-cancer strategy by exploiting BACH1 addiction
2020 - 2023 The model of anti-aging and anti-senescent signal derived from ferroptotic cells
2020 - 2023 Search for therapeutic target factors for small cell lung cancer, focusing on the similarity to hematological tumors and transcriptional regulation of Notch family
2019 - 2021 "The signal-model derived from dead cells"

Show all

Papers (25)：

Liang Liu, Mitsuyo Matsumoto, Miki Watanabe-Matsui, Tadashi Nakagawa, Yuko Nagasawa, Jingyao Pang, Bert K.K. Callens, Akihiko Muto, Kyoko Ochiai, Hirotaka Takekawa, et al. TANK Binding Kinase 1 Promotes BACH1 Degradation through Both Phosphorylation-Dependent and -Independent Mechanisms without Relying on Heme and FBXO22. International Journal of Molecular Sciences. 2024
Keisuke Tada, Hironari Nishizawa, Hiroki Shima, Akihiko Muto, Motoshi Wada, Kazuhiko Igarashi. Cysteine restriction induces ferroptosis depending on the polyamine biosynthetic pathway in hepatic cancer cells. 2024
Riko Irikura, Hironari Nishizawa, Kazuma Nakajima, Mie Yamanaka, Guan Chen, Kozo Tanaka, Masafumi Onodera, Mitsuyo Matsumoto, Kazuhiko Igarashi. Ferroptosis model system by the re-expression of BACH1. Journal of biochemistry. 2023
Hironari Nishizawa, Mie Yamanaka, Kazuhiko Igarashi. Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal. The FEBS Journal. 2023
Masaki Sato, Mitsuyo Matsumoto, Yuriko Saiki, Mahabub Alam, Hironari Nishizawa, Masahiro Rokugo, Andrey Brydun, Shinji Yamada, Mika K. Kaneko, Ryo Funayama, et al. Supplementary Figure S2 from BACH1 Promotes Pancreatic Cancer Metastasis by Repressing Epithelial Genes and Enhancing Epithelial-Mesenchymal Transition. 2023

ｍore...

MISC (36)：

西澤弘成, 五十嵐和彦. フェロトーシスにおける鉄代謝とその遺伝子発現制御. 実験医学 2023年5月号. 2023. 41. 8. 1318-1322
Hironari Nishizawa, Kazuhiko Igarashi. Ferroptosis -Competitively regulation by transcription factors NRF2 and BACH1, and propagation of cell deaths. 2022
中嶋一真, 西澤弘成, 成川礼, 松本光代, 五十嵐和彦. ビリベルジン結合型シアノバクテリオクロムを用いたフェロトーシス高感受性細胞の検出. 日本生化学会大会プログラム・講演要旨集. 2021. 94回. [P-498]
西澤弘成, 松本光代, 五十嵐和彦. 転写因子BACH1が活性化するフェロトーシス細胞由来抗老化シグナルモデル. 日本生化学会大会プログラム・講演要旨集. 2021. 94回. [2T13a-487)]
五十嵐和彦, 西澤弘成, 松本光代. エピゲノムによるがんの表現型多様性及び可塑性の制御 BACH1遺伝子制御ネットワークによる膵癌細胞の多様性と転移の制御. 日本癌学会総会記事. 2021. 80回. [S13-3]

ｍore...

Lectures and oral presentations (9)：

BACH1-controlled ferroptotic cell-derived anti-aging signaling model
(Cold Spring Harbor Asia Conference, Iron, Reactive oxygen species & Ferroptosis in Life, Death & Disease 2022)
BACH1 inhibits aging-related phenotypes by promoting ferroptosis and secreted substances
(The 94th Annual Meeting of the Japanese Biochemical Society 2021)
The gene regulatory network of ferroptosis controlled by the transcription factor BACH1
(The 93rd Annual Meeting of the Japanese Biochemical Society 2020)
Bach1 inhibits cellular senescence through promoting ferroptosis
(Keystone Symposia, Pushing the Limits of Healthspan and Longevity 2018)
Bach1によるフェロトーシス誘導と細胞老化抑制による細胞運命の二極化
(生命科学系学会合同年次大会 2017)

ｍore...

Education (2)：

Professional career (1)：

Work history (4)：

2019/04 - 現在 Tohoku University graduate school of Medicine Biochemistry Postdoctoral fellow
2015/04 - 2019/03 東北大学大学院医学系研究科生物化学分野博士課程
2012/04 - 2015/03 Cancer institute hospital of Japanese foundation for cancer research Clinical oncology for lung cancer
2009/04 - 2012/03 Hiraka general hospital

Awards (2)：

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page