2019 - 2022 Development of Adsorption System for Environmental Contaminants using temperature-responsive self-assembling peptides
2019 - 2020 ハイブリッド型天然物様中分子の一挙創製
2019 - 2020 溶媒摂動法を用いた核内受容体化学研究:リガンド結合特性の評価と創薬への応用
2017 - 2020 学際的創薬化学研究:合成と活性評価について
2016 - 2017 天然物様中分子化合物の短段階合成と機能評価
2016 - 2017 化学的摂動条件下における酵素阻害剤の活性部位特異性評価法の確立と展開
2014 - 2017 効率的な生薬成分抽出法の開発とヒアルロン酸分解酵素阻害剤の探索
2014 - 2015 生薬成分の一挙誘導化による四置換炭素含有新規αーアミノ酸誘導体の創製研究
2010 - 2012 C-O軸性不斉エノラート化学の確立と展開
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Papers (27):
Keisuke Tomohara*, Satoru Kusaba, Mana Masui, Tatsuya Uchida, Hisanori Nambu, Takeru Nose*. Ammonium carboxylates in ammonia-Ugi reaction: one-pot synthesis of α,α-disubstituted amino acid derivatives including unnatural dipeptides. Org. Biomol. Chem. 2024. 22. 6999-7005
Hisanori Nambu, Yuta Onuki, Kana Aso, Momoka Kanamori, Keisuke Tomohara, Kiyoshi Tsuge, Takayuki Yakura. Ring expansion of spirocyclopropanes with stabilized sulfonium ylides: highly diastereoselective synthesis of cyclobutanes. Chemical Communications. 2024. 60. 4537-4540
Keisuke Tomohara*, Naoki Tanaka, Kohei Yoshida, Naoto Hasegawa, Isao Adachi, Takeru Nose. Development of Learning Materials of English Writing for Undergraduate Students Using History of Pharmaceutical Sciences. The Japanese Journal for The History of Pharmacy. 2023. 58. 100-109
Keisuke Tomohara*, Juthamart Maneene, Nao Ohashi, Takeru Nose, Rintaro Fujii, Min Jo Kim, Sijia Sun, Suresh Awale*. Ugi Adducts as Novel Anti-Austerity Agents Against PANC-1 Human Pancreatic Cancer Cell Line: A Rapid Synthetic Approach. Biological and Pharmaceutical Bulletin. 2023. 46. 1412-1420
Daiki Tatsubo, Keitaro Suyama, Naoki Sakamoto, Keisuke Tomohara, Suguru Taniguchi, Iori Maeda, Takeru Nose. Determining the Sequence Dependency of Self-Assembly of Elastin-Like Peptides Using Short Peptide Analogues with Shuffled Repetitive Sequences. Biochemistry. 2023. 62. 2559-2570