Tanaka Yoshinori

タナカヨシノリ | Tanaka Yoshinori

Affiliation and department：
Job title： Assistant Professor

Research field (4)： Cell biology , Veterinary medicine , Molecular biology , Neuroanatomy and physiology

Research keywords (15)： PI(3)P , ゲノム編集 , オートファゴソーム , オートリソソーム , vacuolin-1 , abemaciclib , prion , Vesicular Transport , profilin1 , autophagy , lysosome , TDP-43 , progranulin , ALS , FTLD

Research theme for competitive and other funds (12)：

2023 - 2026 TDP-43の分解と分泌を制御する膜輸送機構の解明
2021 - 2026 Generation of African Swine Fever virus-resistant pigs by applying the concept of gene editing technology
2022 - 2023 Development of the treatment for FTLD-TDP using anti-cancer agent abemaciclib
2020 - 2023 Suppression of neurodegeneration through the interactive action between progranulin and glycolysis
2021 - 2023 核タンパク質TDP-43の細胞質内蓄積におけるプログラニュリンの役割

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Papers (27)：

Yoshinori Tanaka, Lina Kozuma, Hirotsugu Hino, Kosuke Takeya, Masumi Eto. Abemaciclib and Vacuolin-1 decrease aggregate-prone TDP-43 accumulation by accelerating autophagic flux. Biochemistry and Biophysics Reports. 2024. 38. 101705-101705
Yoshinori Tanaka, Shun-ichi Ito, Genjiro Suzuki. TDP-43 Secretion via Extracellular Vesicles Is Regulated by Macroautophagy. Autophagy Reports. 2023. 3. 1
Jason A. Kirkbride, Garbo Young Nilsson, Jee In Kim, Kosuke Takeya, Yoshinori Tanaka, Hiroshi Tokumitsu, Futoshi Suizu, Masumi Eto. PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis. Biomolecules. 2023. 13. 12. 1741-1741
Yoshinori Tanaka, Shun-ichi Ito, Yuki Honma, Masato Hasegawa, Fuyuki Kametani, Genjiro Suzuki, Lina Kozuma, Kosuke Takeya, Masumi Eto. Dysregulation of the Progranulin-driven Autophagy-lysosomal Pathway Mediates Secretion of the Nuclear Protein TDP-43. Journal of Biological Chemistry. 2023. 105272-105272
Yoshinori Tanaka, Hirotsugu Hino, Kosuke Takeya, Masumi Eto. Abemaciclib and Vacuolin-1 induce vacuole-like autolysosome formation - A new tool to study autophagosome-lysosome fusion. Biochemical and biophysical research communications. 2022. 614. 191-197

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MISC (7)：

Yoshinori Tanaka. Progranulin, a responsible gene for frontotemporal lobar degeneration, has a functional role in lysosome. TO IGAKUKEN NEWS. 2017. 25. 4
M. Kanazawa, K. Kawamura, T. Takahashi, M. Miura, Y. Tanaka, M. Koyama, M. Toriyabe, H. Igarashi, T. Nakada, M. Nishizawa, et al. PROGRANULIN MEDIATES NEUROVASCULAR PROTECTION VIA MULTIPLE THERAPEUTIC EFFECTS IN EXPERIMENTAL ACUTE ISCHEMIC STROKE. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2016. 36. 579-580
Yoshinori Tanaka. The mechanism of familial amyotrophic lateral sclerosis due to Profilin 1 gene mutation. TO IGAKUKEN NEWS. 2016. 22. 3
金澤雅人, 川村邦雄, 高橋哲哉, 田中良法, 三浦南, 小山美咲, 鳥谷部真史, 五十嵐博中, 中田力, 西原眞杉, et al. 実験的虚血性脳卒中に対するprogranulinの様々なの治療効果(Multiple therapeutic effects of progranulin on experimental ischemic stroke). 臨床神経学. 2015. 55. Suppl. S219-S219
三浦南, 金澤雅人, 川村邦雄, 高橋哲哉, 田中良法, 小山美咲, 鳥谷部真史, 五十嵐博中, 中田力, 西原眞杉, et al. プログラニュリンは神経細胞保護効果・抗炎症作用をもつ. 脳循環代謝. 2014. 26. 1. 219-219

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Books (1)：

Progranulin and Central Nervous System Disorders
Springer 2019

Lectures and oral presentations (5)：

TDP-43病理形成をめぐる冒険
(研究打ち合わせ@産総研つくばセンター6-10棟 2024)
抗がん剤アベマシクリブによるFTLD-TDP病態抑制効果の検討
(第7回先進医薬研究報告会 2023)
プログラニュリンによるソルチリン非依存性のリソソーム酸性化機構の解析
(第4回プログラニュリン研究会 2019)
原因タンパク質から探るFTLD/ALSの発症機構
(第57回獣医学特論 2016)
加齢時の脳内恒常性維持機構における成長因子プログラニュリンの関与
(第155回日本獣医学会学術集会 2013)

Education (2)：

2010 - 2014 The University of Tokyo Graduate School of Agricultural and Life Sciences Veterinary Medicine
2004 - 2010 Yamaguchi Univerity Agriculture Veterinary Medicine

Professional career (1)：

博士 (獣医学) (東京大学)

Work history (6)：

2019/04 - 現在 Okayama University of Science Department of Veterinary Medicine Assistant Professor
2017/04 - 2019/03 Cambridge Institute for Medical Research Department of Medical Genetics Research Associate
2014/04 - 2017/03 JSPS Post-Doctoral Research Fellow (PD)
2014/04 - 2017/03 Tokyo Metropolitan Institute of Medical Science Dementia Research Project Researcher
2012/04 - 2014/03 JSPS Research Fellow (DC2)

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Awards (4)：

2017/08 - British Council Japanese Association (BCJA) British Council Japanese Association Scholarship
2010/04 - The Japan Scholarship Foundation (JASSO) Scholarship for Graduate Students
2010/03 - The Japanese Society of Veterinary Science Best Poster Award
2004/04 - The Japan Scholarship Foundation (JASSO) Scholarship for Undergraduate Students

Association Membership(s) (7)：

日本獣医学会 , 日本細胞外小胞学会 , 日本分子生物学会 , プログラニュリン研究会 , THE JAPAN NEUROSCIENCE SOCIETY , JAPAN SOCIETY FOR DEMENTIA RESEARCH , THE JAPANESE BIOCHEMICAL SOCIETY

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