Rchr
J-GLOBAL ID：201901017810199283
Update date: Feb. 01, 2024
Sho Aki
Sho Aki
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Affiliation and department：
The University of Tokyo Research Center for Advanced Science and Technology
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Detailed information
Research field (3)：
Cell biology
, Physiology
, Tumor biology
Research keywords (6)：
ホスホイノシタイド
, ミトコンドリア
, オルガネラ
, エンドサイトーシス
, 細胞内小胞輸送
, 血管新生
Research theme for competitive and other funds (4)：
2020 - 2023 II型PI3キナーゼによるメンブレントラフィック制御を介した心臓・血管の機能調節
2018 - 2020 New mechanisms of perinatal cardiovascular regulation by class II PI3K
2016 - 2018 Class II PI3K regulate receptor endocytosis and endosomal signaling
2014 - 2017 Regulation of membrane trafficking through PI(3)P-metabolizing enzymes in endothelial cells.
Papers (18)：
Juri Sakata, Toshifumi Tatsumi, Akira Sugiyama, Akihiro Shimizu, Yuya Inagaki, Hiroto Katoh, Takefumi Yamashita, Kazuki Takahashi, Sho Aki, Yudai Kaneko, et al. Antibody-mimetic drug conjugate with efficient internalization activity using anti-HER2 VHH and duocarmycin. Protein Expression and Purification. 2024. 214. 106375-106375
Ryuichi Nakahara, Sho Aki, Maki Sugaya, Haruka Hirose, Miki Kato, Keisuke Maeda, Daichi M Sakamoto, Yasuhiro Kojima, Miyuki Nishida, Ritsuko Ando, et al. Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth. The EMBO journal. 2023. 42. 22. e114032
Miki Kato, Keisuke Maeda, Ryuichi Nakahara, Haruka Hirose, Ayano Kondo, Sho Aki, Maki Sugaya, Sana Hibino, Miyuki Nishida, Manami Hasegawa, et al. Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils. PNAS nexus. 2023. 2. 10. pgad306
Akihiro Kitagawa, Tsuyoshi Osawa, Miwa Noda, Yuta Kobayashi, Sho Aki, Yusuke Nakano, Tomoko Saito, Dai Shimizu, Hisateru Komatsu, Maki Sugaya, et al. Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma. British journal of cancer. 2023. 128. 12. 2206-2217
Sho Aki, Ryuichi Nakahara, Keisuke Maeda, Tsuyoshi Osawa. Cancer metabolism within tumor microenvironments. Biochimica et biophysica acta. General subjects. 2023. 1867. 5. 130330-130330
ｍore...
MISC (12)：
安藝翔, 大澤毅. Understanding cell-cell to cell-organelle to organelle mediated diseases. 実験医学. 2023. 41. 15
安藝 翔. クラスII PI3K はエンドサイトーシスを制御して血管新生に関与する. 月刊「細胞」 特集 : 血管のバイオロジー. 2018
西田洋児, 安藝翔, 山本宜孝, 加藤寛城, 飯野賢治, 木村圭一, 多久和陽, 竹村博文. 内胸動脈グラフトの血管攣縮に対するRho-kinase inhibitor(Fasudil)の抗攣縮効果. 日本外科学会定期学術集会(Web). 2018. 118th. ROMBUNNO.PS-196-3 (WEB ONLY)
Phosphatidylinositol 3-kinase class IIα-isoform PI3K-C2α is required for transforming growth factor β-induced Smad signaling in endothelial cells. 2016. 125. 2. 73-74
Saori Koizumi, Kazuaki Yoshioka, Sho Aki, Yoh Takuwa. Phosphatidylinositol 3-kinase class II α isoform (PI3K-C2α) maintains vascular integrity. The Juzen Medical Society Kanazawa University. 2016. 125. 2. 77-78
ｍore...
Work history (2)：
2021/01 - 現在 The University of Tokyo
2015/07 - 2020/12 Kanazawa University
Committee career (2)：
2022 - 現在 日本血管生物医学会 評議員
2019 - 現在 日本生理学会 評議員
Awards (10)：
2023/05 - 血管生物医学会 血管生物若手研究会最優秀賞
2022/12 - 先進医薬研究振興財団 循環医学分野 若手研究者助成
2022/07 - がんと代謝研究会 がんと代謝研究会 ポスター賞
2022/07 - がんと代謝研究会 がんと代謝若手研究会 最優秀賞
2022/03 - 日本生理学会 入澤宏・彩記念若手研究奨励賞日本生理学会奨励賞
2021/09 - 武田科学振興財団医学系研究助成
2020/09 - 第34回 北國がん基金
2016/07 - 第14回 高安賞優秀論文賞
2016/03 - 第2回 血管生物若手研究会最優秀賞
2015/07 - ONO Pharmaceutical Travel Awards for Young Japanese Investigators. 14th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases.
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