Saeki Hiroshi

2021 - 2024 Development of a innovative combination therapy of hyperthermia and immune checkpoint inhibitors

2021 - 2024 頭頸部・食道の損傷・修復異常に着目した発癌・進展の機序解明と個別化治療戦略の確立

2020 - 2023 革新的治療ツールを利用した癌微小管ダイナミクス制御による消化管癌の克服を目指して

2019 - 2022 Development of a new treatment method aimed at enhancing the effect of irinotecan therapy for gastrointestinal cancer

2018 - 2021 Molecular mechanism of carcinogenesis of head and neck and esophagus induced by cigarette smoking and alcohol drinking: Aiming to establishment of personalized treatment strategy

2018 - 2021 Exploring an effective irinotecan treatment by way of biomarker and a new remedy

2018 - 2020 RNA involvement in the process of chemotherapy-induced DNA replication stress

2017 - 2020 Molecular mechanism of therapy-induced senescence caused by replicative stress

2017 - 2020 Molecular mechanisms of cytokinesis completion and cell fate decision after cytokinesis failure

2015 - 2020 Development of Innovative Treatment Targeting the Sphere Formation Mechanism Involving Cancer Stem Cells

2016 - 2019 Elucidation of molecular mechanism of resistance to chemoradiotherapy of esophageal cancer and development of new treatment focusing on cancer stem cells

2016 - 2019 Elucidation of molecular mechanisms of and development of combined therapy with immune checkpoint inhibitors for digestive tract cancer

2016 - 2019 Molecular mechanism of the cancer odor and development of the new cancer diagnostic system

2016 - 2018 Development of the the innovative treatment and the proposal of the Self-niche hypothesis in refractory cancer

2015 - 2018 Molecular mechanism of development and progression of upper aerodigestive tract cancer induced by cigarette smoking and alcohol drinking

2015 - 2018 Strategy of anti-cancer therapy for gastrointestinal cancers targeting non-oncogenic addiction

2015 - 2018 Clinical application to significance and growth control of the chromosome instability in carcinogenesis, the progress of gastrointestinal cancer

2014 - 2017 Gemonic alteration, molecular subtypes and drug sensitivity in breast cancer

2014 - 2017 Investigation of chemoradiation sensitivity based on the DNA repair mechanism in esophageal carcinoma

2013 - 2016 Chromosomal dynamics and development of novel therapy in gastrointestinal tract cancer

2013 - 2016 Establishment of the new therapy based on inflammatory mediator and DNA methylation in colorectal cancer

2013 - 2016 The analysis of the spindle checkpoint protens and the application to the new molecular targetted therapy for colorectal cancer.

2013 - 2016 The study for molecular mechanism of drug resistance and development of new treatment which aimed at colorectal cancer stem cell.

2012 - 2016 DNA mismatch repair gene analysis predicts the response to anticancer drug sensitivity in gastrointestinal cancers for tailored therapy.

2014 - 2015 ヒト癌免疫編成機構の分子機序解明と免疫合成致死を誘導する革新的免疫療法の研究開発

2012 - 2015 Pre-clinical application of an innovative therapy, "BioKnife", to malignant pleural mesothelioma

2012 - 2015 The study of the sensitivity for gastric cancer neoadjuvant chemotherapy raleting to cancer stem cells

2012 - 2015 Molecular mechanism of esophageal carcinogenesis induced by cigarette smoking and alcohol drinking and its clinical application

2010 - 2012 Innovative treatment strategy for intractable gastroenterological cancer by control of DNA double strand repair pathway

2009 - 2011 A novel treatment strategy for digestive system cancer against angiogenic signal in tumor stroma using nanosize particle.

2009 - 2011 Cigarette smoking, alcohol drinking, oxidative stress and tumor suppressor gene abnormality in the development of esophageal cancer

2009 - 2011 The study of mol ecular mechani sin for gastroi ntesti nat carci nogenesi s derived from chronic inflammation

2008 - 2010 The Y-box binding protein-1 (YB-1) functions in various biological processes, including transcriptional and translational control, DNA repair, drug resistance, and cell proliferation in gastrointestinal malignancies.

2001 - 2004 Detection and clinical application of circulating cancer cells, using highy pricise cancer cell determination system

2003 - 2003 発癌危険因子と遺伝子異常解析に基づいた食道癌発生メカニズムの解明

2001 - 2002 The establishment of the novel strategy of therapy for esophageal cancer

2001 - 2002 発癌過程の遺伝子モニタリングに基づくオーダーメイド治療の確立-DNAマイクロアレイの臨床へのアプローチ-