Rchr
J-GLOBAL ID:201901019063129060   Update date: Oct. 20, 2021

Seki Akihiro

セキ アキヒロ | Seki Akihiro
Affiliation and department:
Job title: 特任助教
Research field  (1): Gastroenterology
Research theme for competitive and other funds  (5):
  • 2020 - 2023 Study of liver restorative therapy for a murine nonalcoholic steatohepatitis model by the administration of immune-suppressive fractions of autologous adipose tissue-derived stromal cells
  • 2020 - 2022 非アルコール性脂肪肝炎による腸管免疫・癌微小環境動態と大腸癌への影響の解明
  • 2019 - 2021 iPS細胞由来間葉系幹細胞の免疫修飾作用を用いた炎症性腸疾患の治療効果と機序解明
  • 2014 - 2017 Analysis of characteristics of cellular subfractions in adipose tissue-derived stromal cells for development of liver repair/regenerative therapy
  • 間葉系幹細胞による非アルコール性脂肪性肝炎に対する治療効果機序解明 (採択番号16K19334,同年から海外留学を行うため,採択を辞退した)
Papers (20):
  • Yoshio Sakai, Shinya Fukunishi, Masayuki Takamura, Kazunori Kawaguchi, Oto Inoue, Soichiro Usui, Shinichiro Takashima, Akihiro Seki, Akira Asai, Yusuke Tsuchimoto, et al. Clinical trial of autologous adipose tissue-derived regenerative (stem) cells therapy for exploration of its safety and efficacy. Regenerative therapy. 2021. 18. 97-101
  • Kazunori Kawaguchi, Yoshio Sakai, Takeshi Terashima, Tetsuhiro Shimode, Akihiro Seki, Noriaki Orita, Yumie Takeshita, Tetsuro Shimakami, Hajime Takatori, Kuniaki Arai, et al. Decline in serum albumin concentration is a predictor of serious events in nonalcoholic fatty liver disease. Medicine. 2021. 100. 31. e26835
  • Han Chen, Kouki Nio, Taro Yamashita, Hikari Okada, Ru Li, Tsuyoshi Suda, Yingyi Li, Phuong Thi Bich Doan, Akihiro Seki, Hidetoshi Nakagawa, et al. BMP9-ID1 signaling promotes EpCAM-positive cancer stem cell properties in hepatocellular carcinoma. Molecular oncology. 2021. 15. 8. 2203-2218
  • Kosuke Ishida, Akihiro Seki, Kazunori Kawaguchi, Alessandro Nasti, Masatoshi Yamato, Hiiro Inui, Takuya Komura, Taro Yamashita, Kuniaki Arai, Tatsuya Yamashita, et al. Restorative effect of adipose tissue-derived stem cells on impaired hepatocytes through Notch signaling in non-alcoholic steatohepatitis mice. Stem cell research. 2021. 54. 102425-102425
  • Noboru Takata, Kiyo-Aki Ishii, Hiroaki Takayama, Mayumi Nagashimada, Kyoko Kamoshita, Takeo Tanaka, Akihiro Kikuchi, Yumie Takeshita, Yukako Matsumoto, Tsuguhito Ota, et al. LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH. Scientific reports. 2021. 11. 1. 555-555
more...
MISC (22):
  • 藤永 晴夫, 酒井 佳夫, 山下 竜也, 荒井 邦明, 寺島 健志, 小村 卓也, 関 晃裕, 川口 和紀, ナスティ・アレッサンドロ, 吉田 佳子, et al. 膵臓癌細胞株に対する陽子線・X線照射における遺伝子発現プロファイル変化の特徴. 膵臓. 2018. 33. 3. 468-468
  • Masatoshi Yamato, Yoshio Sakai, Hatsune Mochida, Akihiro Seki, Keiko Yoshida, Tuyen T. Ho, Alessandro Nasti, Takashi Wada, Shuichi Kaneko. Adipose tissue derived stromal/stem cells retarded progression of hepatic fibrosis by suppressing IL17A related inflammation in early stage of NASH. HEPATOLOGY. 2017. 66. 1041A-1041A
  • Yoshio Sakai, Akihiro Seki, Hajime Sunagozaka, Takeshi Terashima, Hatsune Mochida, Alessandro Nasti, Masatoshi Yamato, Kousuke Ishida, Masao Honda, Shuichi Kaneko. Clinical study of liver regenerative therapy of cirrhosis using autologous adipose tissue-derived stromal cells and the biological characters of the obtained cells. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. 2016. 31. 394-394
  • Yoshio Sakai, Akihiro Seki, Hajime Sunagozaka, Takeshi Terashima, Kazunori Kawaguchi, Hatsune Mochida, Alessandro Nasti, Geraldine B. Buffa, Masatoshi Yamato, Kosuke, et al. Clinical study of liver regenerative therapy of cirrhosis using autologous adipose tissue-derived stromal cells and the characterization of the obtained stromal cells. HEPATOLOGY. 2016. 64. 601A-601A
  • Yoshio Sakai, Akihiro Seki, Hajime Sunagozaka, Takeshi Terashima, Kazunori Kawaguchi, Hatsune Mochida, Alessandro Nasti, Geraldine B. Buffa, Masatoshi Yamato, Kosuke Ishida, et al. Clinical study of liver regenerative therapy of cirrhosis using autologous adipose tissue-derived stromal cells and the characterization of the obtained stromal cells. HEPATOLOGY. 2016. 64. 601A-601A
more...
Lectures and oral presentations  (5):
  • The Gut Microbiota of Pregnant Women with Crohn's Disease and their Babies is Associated with Abnormalities in the Adaptive Immune System - Results from the Meconium Study.
    (DDW 2018)
  • CD45+ fraction in murine adipose tissue-derived stromal cells is therapeutical to Concanavalin A-induced murine acute hepatitis model.
    (AASLD 2015 2015)
  • Immunomodulation effect of adipose-tissue derived stromal/stem cell is capable of suppressing murine Concanavalin A-induced hepatitis.
    (AASLD 2013 2013)
  • Therapeutic effect of adipose derived mesenchymal stem cell to murine NASH liver cirrhosis inactivating Kupffer/Macrophage and helper T cell
    (AASLD 2012 2012)
  • Adipose tissue derived mesenchymal stem cells are capable to modulate liver inflammation in mouse models of non-alcoholic steatohepatitis.
    (AASLD 2009 2009)
Education (2):
  • 2007 - 2014 Kanazawa University
  • 1998 - 2005 Toyama Medical and Pharmaceutical University
Work history (2):
  • 2016/04 - 2019/03 Icahn School of Medicine at Mount Sinai gastroenterology post doctoral fellow
  • 2014/04 - 2016/03 金沢大学
Awards (1):
  • 2013/10 - The Japan Society of Hepatology 12th Otsuka award
Association Membership(s) (5):
THE JAPANESE SOCIETY FOR IMMUNOLOGY ,  The Japan Society of Hepatology ,  JAPAN GASTROENTEROLOGICAL ENDOSCOPY SOCIETY ,  JAPANESE SOCIETY OF GASTROENTEROLOGY ,  THE JAPANESE SOCIETY OF INTERNAL MEDICINE
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