Research field (2)：
Pharmaceuticals - chemistry and drug development
, Environmental and pharmaceutical development resources
Research keywords (8)：
漢方薬
, アポトーシス
, トリテルペン配糖体
, 生薬
, cancer
, saponin
, steroidal glycoside
, 天然物化学
Research theme for competitive and other funds (3)：
2023 - 2026 Search for new seeds of anti-cancer agents targeting PARP from natural products
2022 - 2025 非内因性経路に着目した植物由来サポニンのアポトーシス誘導メカニズムの解明
2019 - 2021 Elucidation of induction of apoptosis by steroidal glycosides via a mitochondria-independent pathway
Papers (31)：
Yuka Yoshizawa, Akihito Yokosuka, Mina Inomata, Tomoki Iguchi, Yoshihiro Mimaki. Steroidal constituents in the whole plants of Helleborus niger and their cytotoxic activity in vitro. Phytochemistry. 2025. 229. 114272
Takashi Shii, Tomoki Iguchi, Minpei Kuroda, Tamami Shimazaki, Ryuichiro Suzuki, Yoshihiro Mimaki. Quantitative analyses of sennosides A and B in eight ethical bofutsushosan extract products. Traditional & Kampo Medicine. 2024. 11. 13-21
Tamami Shimazaki, Tomoki Iguchi, Naoki Takahashi, Yukako Sano, Kaito Nakamura, Yoshihiro Mimaki. Steroidal glycosides from Ornithogalum thyrsoides bulbs and their cytotoxicity toward HL-60 human promyelocytic leukemia cells and SBC-3 human small-cell lung cancer cells. Phytochemistry. 2024. 219. e113985
松尾侑希子, 井口巴樹, 黒田明平, 三宅克典, 加藤宏直, 木村優花, 三巻祥浩. Triterpene Glycosides from the Underground Parts of Alternanthera philoxeroides Designated as an Invasive Alien Species and Their Cytotoxicity. 生薬学雑誌. 2024. 78. 1. 109-114
Tamami Shimazaki, Tomoki Iguchi, Aki Kanda, Kie Yamamoto, Naoki Takahashi, Yoshihiro Mimaki. Six unprecedented steroidal glycosides from Allium atropurpureum bulbs and their cytotoxicities against SBC-3 human small-cell lung cancer cells. Phytochemistry Letters. 2023. 57. 200-209
吉澤由佳, 猪俣美菜, 横須賀章人, 井口巴樹, 三巻祥浩. Chemical components of Ranunculaceae plants (39) Apoptosis-inducing activity of bufadienolide derivative from the whole plants of Helleborus niger. 日本薬学会年会要旨集(Web). 2023. 143rd
高橋直熙, 井口巴樹, 中村凱士, 佐野友佳子, 三巻祥浩. Structural characterization of novel steroidal glycosides from the bulbs of Ornithogalum thyrsoides and their cytotoxicity. 日本薬学会年会要旨集(Web). 2023. 143rd
